The Proof Podcast - A Space for Science Based Conversation Exploring the Health and Longevity Benefits That Come With Mastering Nutrition, Physical Exercise, Mindfulness and Recovery

3min

Is Aging a Disease?

3min

Is Aging Causing Cardiovascular Disease?

3min

The Relationship Between Aging and Diseases

3min

The Markers of Aging - Why Are They Important?

4min

Evolutionarily Conserved Mechanisms of Aging

5min

Are We on the Cusp of Immortality?

4min

The Importance of Environment and Lifestyle on Longevity

2min

10.

Epigenetic Changes

5min

11.

What Does an Epigenetic Clock Mean?

4min

12.

What Is a Senescent Cell?

2min

13.

Is There a Connection Between DNA Mutation and Ageing?

3min

14.

Reprogramming the Epigenome

2min

15.

What Are Your Buckets in the Biology of Aging?

3min

16.

I'm Glad You Bring Up Happiness

3min

17.

Is Social Media a Good Idea?

3min

18.

The New ApoB Biomarker Is Better Than LDL Cholesterol

3min

19.

Sleep and the Biology of Aging

3min

20.

Is Your Aura Ring Helping You Sleep Better?

5min

21.

Is Activating mTOR a Detriment to Building Muscle?

3min

22.

Is Rapamycin a Good Anti-Sarcopenia Treatment?

2min

23.

Is Rapamycin Protecting Against Sarcopenia?

3min

24.

Is Rapamycin a Good Alternative to Healthy Lifestyle?

3min

25.

Are You Going to Put More Weight on What You Think We Know About Human Nutrition?

5min

26.

Do You Know How Caloric Restrictions Affect Aging?

5min

27.

Is Calorie Restriction a Good Thing?

3min

28.

Is There Evidence That Fasting Mimicking Diet Can Affect Aging?

2min

29.

Is There a Benefit With Protein Restriction or Amino Acid Refrain?

5min

30.

Is There a Difference Between a Mouse and a Cage?

4min

31.

The RDA for Protein Consumption

2min

32.

The Importance of Context in Nutritional Strategies

2min

33.

Plant Protein vs. Meat Protein

4min

34.

The Longevity Effect of Fruits and Vegetables

6min

35.

The Role of Resveritrol in Aging

3min

36.

Is Resveritrol a Longevity Gene?

3min

37.

Is Terra Still Being a Longevity Drug?

2min

38.

Plant-Based Ferments - 15 Must Have Recipes to Take Your Fermented Food Game to the Next Level

4min

39.

Are There Any Other Supplements That Are Beneficial for Longevity?

4min

40.

Are NAD Precursors Getting Validated?

3min

41.

Is NAD Dysregulation a Cause of Aging?

2min

42.

Rapid Mice - Is Rapinoe a Better NAD Precursor?

3min

43.

Can You Turn Down mTOR and Increase Lifetime?

4min

44.

Organ Transplant Patients - Does Rapamycin Have a Positive Effect on Aging?

2min

45.

Are You Using Rapamycin Off Label?

2min

46.

Is Ephrolimus the Same as Rapamycin?

2min

47.

Rapamycin - What Are the Risks?

5min

48.

Is FDA Approval for Aging Going to Be an Important Piece of the Puzzle?

4min

49.

TAME Study - Is TAME a Single Endpoint?

2min

50.

Is Metformin Affecting Aging?

5min

51.

Are There Possible Drug or Supplement Interactions?

5min

52.

The Future of Longevity Interventions

5min

53.

The Ethical Implications of Prolonging Human Life

3min

54.

OptiSpan - What's Next?

2min

55.

Dog Aging Project - Should I Feed My Dog Once a Day?

2min

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.

Specifically, we discuss:

Intro (00:00)
Aging and disease (03:42)
Evolutionary conserved processes and human life span (17:41)
Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29)
Aging process and the burden of senescence cells (34:06)
Keys to a longer, healthier life (45:08)
Sleep and exercise (55:38)
Calorie restriction, longevity, and prolonged fasting (1:15:23)
Protein restriction and its implications (1:32:14)
Plant protein vs animal protein (1:43:31)
Natural occurring polyphenols and supplements related to longevity (1:53:06)
Rapamycin and rapamycin derivatives (2:13:53)
Anti-aging compounds (2:29:38)
Ethical implications of prolonging the life (2:51:08)
Outro (2:57:23)

To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.

Discover more insights and supporting resources in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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