The Proof with Simon Hill Biology of aging and tips to slow it down | Matt Kaeberlein, PhD
03:04:48
Aging Definition
- Aging is a complex process, not easily defined as a disease or not.
- Biological aging is the root cause of most major diseases in developed countries.
Aging and Disease Risk
- Aging increases the risk of diseases exponentially, not linearly.
- It creates a physiological state of increased vulnerability, regardless of specific mechanisms.
Healthspan vs. Lifespan
- The concept of healthspan, maximizing healthy periods of life, is key.
- Focus on functional decline with age, even in the absence of diagnosed disease.
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Introduction
00:00 • 3min
The Proof Podcast - A Space for Science Based Conversation Exploring the Health and Longevity Benefits That Come With Mastering Nutrition, Physical Exercise, Mindfulness and Recovery
02:36 • 3min
Is Aging a Disease?
05:17 • 3min
Is Aging Causing Cardiovascular Disease?
08:27 • 3min
The Relationship Between Aging and Diseases
11:55 • 3min
The Markers of Aging - Why Are They Important?
15:19 • 4min
Evolutionarily Conserved Mechanisms of Aging
19:11 • 5min
Are We on the Cusp of Immortality?
24:10 • 4min
The Importance of Environment and Lifestyle on Longevity
27:58 • 2min
Epigenetic Changes
29:39 • 5min
What Does an Epigenetic Clock Mean?
35:07 • 4min
What Is a Senescent Cell?
38:52 • 2min
Is There a Connection Between DNA Mutation and Ageing?
41:05 • 3min
Reprogramming the Epigenome
44:31 • 2min
What Are Your Buckets in the Biology of Aging?
46:35 • 3min
I'm Glad You Bring Up Happiness
49:33 • 3min
Is Social Media a Good Idea?
52:13 • 3min
The New ApoB Biomarker Is Better Than LDL Cholesterol
54:51 • 3min
Sleep and the Biology of Aging
58:20 • 3min
Is Your Aura Ring Helping You Sleep Better?
01:01:45 • 5min
Is Activating mTOR a Detriment to Building Muscle?
01:06:48 • 3min
Is Rapamycin a Good Anti-Sarcopenia Treatment?
01:09:39 • 2min
Is Rapamycin Protecting Against Sarcopenia?
01:11:17 • 3min
Is Rapamycin a Good Alternative to Healthy Lifestyle?
01:14:26 • 3min
Are You Going to Put More Weight on What You Think We Know About Human Nutrition?
01:17:26 • 5min
Do You Know How Caloric Restrictions Affect Aging?
01:22:49 • 5min
Is Calorie Restriction a Good Thing?
01:27:59 • 3min
Is There Evidence That Fasting Mimicking Diet Can Affect Aging?
01:31:28 • 2min
Is There a Benefit With Protein Restriction or Amino Acid Refrain?
01:33:57 • 5min
Is There a Difference Between a Mouse and a Cage?
01:38:43 • 4min
The RDA for Protein Consumption
01:42:43 • 2min
The Importance of Context in Nutritional Strategies
01:44:47 • 2min
Plant Protein vs. Meat Protein
01:46:25 • 4min
The Longevity Effect of Fruits and Vegetables
01:50:08 • 6min
The Role of Resveritrol in Aging
01:55:59 • 3min
Is Resveritrol a Longevity Gene?
01:59:04 • 3min
Is Terra Still Being a Longevity Drug?
02:02:23 • 2min
Plant-Based Ferments - 15 Must Have Recipes to Take Your Fermented Food Game to the Next Level
02:04:19 • 4min
Are There Any Other Supplements That Are Beneficial for Longevity?
02:08:03 • 4min
Are NAD Precursors Getting Validated?
02:12:22 • 3min
Is NAD Dysregulation a Cause of Aging?
02:15:09 • 2min
Rapid Mice - Is Rapinoe a Better NAD Precursor?
02:17:02 • 3min
Can You Turn Down mTOR and Increase Lifetime?
02:19:58 • 4min
Organ Transplant Patients - Does Rapamycin Have a Positive Effect on Aging?
02:23:43 • 2min
Are You Using Rapamycin Off Label?
02:25:21 • 2min
Is Ephrolimus the Same as Rapamycin?
02:27:22 • 2min
Rapamycin - What Are the Risks?
02:29:19 • 5min
Is FDA Approval for Aging Going to Be an Important Piece of the Puzzle?
02:33:55 • 4min
TAME Study - Is TAME a Single Endpoint?
02:37:26 • 2min
Is Metformin Affecting Aging?
02:39:01 • 5min
Are There Possible Drug or Supplement Interactions?
02:43:52 • 5min
The Future of Longevity Interventions
02:48:35 • 5min
The Ethical Implications of Prolonging Human Life
02:53:49 • 3min
OptiSpan - What's Next?
02:57:15 • 2min
Dog Aging Project - Should I Feed My Dog Once a Day?
02:59:27 • 2min
Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.
Specifically, we discuss:
- Intro (00:00)
- Aging and disease (03:42)
- Evolutionary conserved processes and human life span (17:41)
- Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29)
- Aging process and the burden of senescence cells (34:06)
- Keys to a longer, healthier life (45:08)
- Sleep and exercise (55:38)
- Calorie restriction, longevity, and prolonged fasting (1:15:23)
- Protein restriction and its implications (1:32:14)
- Plant protein vs animal protein (1:43:31)
- Natural occurring polyphenols and supplements related to longevity (1:53:06)
- Rapamycin and rapamycin derivatives (2:13:53)
- Anti-aging compounds (2:29:38)
- Ethical implications of prolonging the life (2:51:08)
- Outro (2:57:23)
To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.
Discover more insights and supporting resources in the full show notes.
Enjoy, friends.
Simon
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Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
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