The Proof with Simon Hill cover image

Biology of aging and tips to slow it down | Matt Kaeberlein, PhD

The Proof with Simon Hill

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Can You Turn Down mTOR and Increase Lifetime?

In 2009, the National Institute on Aging Interventions Testing Program showed that you could increase lifespan in mice with rapamycin. You can reverse or delay aging in pretty much every tissue and organ of a mouse where this has been studied. If we're modulating the biology of aging, we would expect to modulate functional declines and molecular changes that go along with aging. But right now, there isn't a lot of solid data either direction in terms of how risky is it and how beneficial is it going to be?

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