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Matt Kaeberlein

Host of The Optispan Podcast, researcher in the field of aging.

Top 10 podcasts with Matt Kaeberlein

Ranked by the Snipd community
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1,095 snips
Jan 27, 2025 • 2h 42min

#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Matt Kaeberlein, Richard Miller

In this enlightening discussion, aging experts Steven Austad, Richard Miller, and Matt Kaeberlein delve into the science of aging. They explore the connection between healthspan and lifespan, emphasizing effective interventions like rapamycin and senolytics. The panel critiques the funding challenges in aging research and advocates for more focus on geroscience. Additionally, they examine the complexities of biological age measurements and the potential of GLP-1 receptor agonists in promoting longevity. Packed with humor, insights, and scientific rigor, this conversation is a must-listen!
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290 snips
Sep 25, 2023 • 2h 51min

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

In this engaging discussion, world-leading experts David Sabatini and Matt Kaeberlein dive into the intriguing world of rapamycin, a molecule known for its longevity potential. They share the fascinating history of rapamycin's discovery and its transformation from an immunosuppressant to a geroprotective agent. The conversation addresses crucial questions about its dosing and timing in humans, while examining groundbreaking studies on lifespan extension in mice. Listeners will also learn about the nuances of mTOR's role in aging and the potential implications for future age-related therapies.
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229 snips
Sep 12, 2022 • 2h 27min

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D

Dr. Matt Kaeberlein, a globally recognized expert on aging from the University of Washington, discusses how nutrition affects longevity. He explores the nuances of calorie restriction and its surprising impacts on lifespan and healthspan. The conversation dives into the effects of dietary protein, mTOR pathways, and the complex roles of IGF-1 and growth hormone. Kaeberlein also examines the potential of epigenetic reprogramming to combat aging and emphasizes the importance of balanced nutrition alongside exercise for optimal health.
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169 snips
Jul 27, 2022 • 2h 28min

#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

Dr. Matt Kaeberlein, a leading researcher on aging from the University of Washington, dives into groundbreaking insights about longevity. He discusses the Dog Aging Project, revealing how canine studies can inform human health. The conversation highlights promising compounds like rapamycin and metformin and their role in extending healthspan. Kaeberlein also shares his personal experiences with aging research, dietary strategies for dogs, and the need for innovative funding in the pursuit of longevity. Tune in for a fascinating look at the future of aging!
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55 snips
Feb 27, 2023 • 3h 5min

Biology of aging and tips to slow it down | Matt Kaeberlein, PhD

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.Specifically, we discuss: Intro (00:00) Aging and disease (03:42) Evolutionary conserved processes and human life span (17:41) Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29) Aging process and the burden of senescence cells (34:06) Keys to a longer, healthier life (45:08) Sleep and exercise (55:38) Calorie restriction, longevity, and prolonged fasting (1:15:23) Protein restriction and its implications (1:32:14) Plant protein vs animal protein (1:43:31) Natural occurring polyphenols and supplements related to longevity (1:53:06) Rapamycin and rapamycin derivatives (2:13:53) Anti-aging compounds (2:29:38) Ethical implications of prolonging the life (2:51:08) Outro (2:57:23) To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.Discover more insights and supporting resources in the full show notes.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary two-week meal plan and high protein Plant Performance recipe book
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54 snips
Aug 27, 2022 • 1h

#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"

Luis von Ahn, co-founder of Duolingo, discusses the evolution of language learning and insights into crowdsourcing. Balaji Srinivasan, a former CTO of Coinbase, dives into the intersection of literature and geopolitical strategies, emphasizing the implications of online ideological battles. Dr. Matt Kaeberlein elaborates on the Dog Aging Project and the revolutionary potential of rapamycin in extending canine lifespans. Together, their conversations offer a melting pot of technology, health, and societal reflections.
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52 snips
Apr 6, 2023 • 1h 57min

Anti-Aging Scientist: What To Eat & When To Eat To Slow The Aging Process | Matt Kaeberlein

Matt Kaeberlein is a leading anti-aging researcher and the co-Director of the Dog Aging Project. In this conversation, he challenges the myth of 'reverse aging' and introduces rapamycin, a drug with potential health benefits. Kaeberlein emphasizes the effectiveness of exercise and nutrition over complex solutions for longevity. He dives into personalized dietary needs and explores the intriguing relationship between caloric restriction and aging, all while highlighting insights from his work on aging in dogs.
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14 snips
Mar 19, 2024 • 1h 22min

How Dogs Are Going to Make You Live Longer: Rapamycin & Longevity – Matt Kaeberlein : 1145

In this enlightening discussion, Matt Kaeberlein, CEO of Optispan and a leading researcher in the Dog Aging Project, shares his insights on longevity for both humans and dogs. He discusses the pivotal role of diet in promoting health and how rapamycin may reduce age-related inflammation. The conversation also explores the fascinating interplay between dog health studies and human aging, emphasizing the importance of nutrition and innovative research approaches. Kaeberlein sheds light on exciting advancements in aging science and what they mean for our furry friends and ourselves.
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14 snips
Sep 13, 2021 • 2h 41min

#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process

Matt Kaeberlein, a renowned expert on aging, discusses groundbreaking research that links aging with chronic inflammation and the immune system. He highlights the potential of rapamycin and other interventions in extending lifespan. Kaeberlein shares insights from his Dog Aging Project, along with the critical importance of biomarkers and epigenetic clocks. They explore the complex relationships between aging, diseases, and nutritional strategies, suggesting that targeting biological aging may offer more significant benefits than merely treating age-related conditions.
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10 snips
May 16, 2022 • 31min

#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

Join Dr. Matt Kaeberlein, a leading researcher in aging from the University of Washington, as he dives into the fascinating world of anti-aging compounds. They explore the roles of NAD+, metformin, and rapamycin, discussing their potential in extending lifespan. Tune in for insights into aging biomarkers and the challenges in understanding epigenetic clocks. Kaeberlein shares skepticism surrounding commercial aging tests and emphasizes the need for thorough research models to make informed decisions in longevity science.