Peter Attia welcomes David Sabatini and Matt Kaeberlein, experts on rapamycin and mTOR. They discuss the discovery of rapamycin, its potential benefits on lifespan, and the biology behind its effects. They also touch on the dosing of rapamycin in humans and reservations about prescribing it as a longevity drug. Topics include emergence of rapamycin as a geroprotective molecule, groundbreaking mouse study on lifespan extension, and the biochemistry of rapamycin and the mTOR protein complex.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Dr. Matt Kaeberlein is a globally recognized expert on the biology of aging and recurring on The Drive. In this episode, Matt explains his research findings on nutrition as it relates to aging and longevity, including the results from his recent review article in Science. From there, he and Peter dive deep into the literature on calorie restriction (CR), explaining the nuance, benefits for lifespan and healthspan, and potential downsides of CR. He discusses the epigenetic changes that occur with age and potential benefits and downsides of epigenetic reprogramming, often viewed as a panacea for reversing aging. Matt also explains the impact of dietary protein on aging, including the interesting dichotomy around how protein, a critical macronutrient, and rapamycin, a geroprotective molecule, have opposite effects on mTOR. Additionally, he talks about low-protein vs. high-protein diets and their effects on muscle mass and mortality, as well as the impact of IGF-1 signaling and growth hormone on lifespan. We discuss: Challenges with understanding the effects of nutrition and studying interventions for aging [3:30]; How Peter’s and Matt’s convictions on nutrition and thoughts optimal health have evolved [8:15]; Calorie restriction for improving lifespan in animal models [16:15]; Utility of epigenetic clocks and possibility of epigenetic reprogramming [22:00]; Mutations and changes to the epigenome with aging [31:45]; Epigenetic reprogramming: potential benefits and downsides and whether it can work in every organ/tissue [35:15]; First potential applications of anti-aging therapies and tips for aging well [43:00]; Impact of calorie restriction on the immune system, muscle mass, and strength [47:00]; Insights from famous calorie restriction studies in rhesus macaques [55:00]; An evolutionary perspective of the human diet [1:03:45]; Antiaging diets: Separating fact from fiction—Matt’s 2021 review in Science [1:12:30]; Mouse models of time-restricted feeding in the context of calorie restriction [1:19:30]; Nutritional interventions that consistently impact lifespan in mice, and concerns around efficacy in humans [1:27:00]; Differing impact of calorie restriction when started later in life [1:31:00]; Lifespan extension with rapamycin in older mice [1:37:15]; Relationship between protein intake and aging, and mouse studies showing protein restriction can extend lifespan [1:43:30]; Impact of protein intake on mTOR, and why inhibition of mTOR doesn’t cause muscle loss [1:50:45]; Low-protein vs. high-protein diets and their effects on muscle mass, mortality, and more [1:55:30]; The impact of IGF-1 signaling and growth hormone on lifespan [2:06:30]; Parting thoughts on the contribution of nutrition to healthspan and lifespan [2:19:45]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.Please enjoy!This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by LMNT! What is LMNT? It’s a delicious, sugar-free electrolyte drink mix. I’ve stocked up on boxes and boxes of this and usually use it 1–2 times per day. LMNT is formulated to help anyone with their electrolyte needs and perfectly suited to folks following a keto, low-carb, or Paleo diet. If you are on a low-carb diet or fasting, electrolytes play a key role in relieving hunger, cramps, headaches, tiredness, and dizziness.LMNT came up with a very special offer for you, my dear listeners. For a limited time, you can get a free LMNT Sample Pack with any purchase. This special offer is available here: DrinkLMNT.com/Tim.*This episode is also brought to you by Levels! I wrote about the health benefits of using continuous glucose monitors (CGMs) more than ten years ago in The 4-Hour Body. At the time, CGMs were primitive and hard to use. Levels has now made this technology, and the unique insights that come from it, easy and available to everyone. Levels is making glucose monitoring simple, helping you see how food affects your health through real-time feedback. I started tracking my glucose years ago to learn more about what I should and shouldn’t be eating (including quantities, time of day, etc.), based on objective data from my own, unique physiology. Keeping my blood sugar stable is critical to my daily and long-term health and performance goals. Furthermore, poor glucose control is associated with a number of chronic conditions like diabetes, Alzheimer’s disease, heart disease, and obesity. It’s important.If you’re interested in learning more about Levels and trying a CGM yourself, go to Levels.link/Tim.*[06:44] What is aging biology?[08:43] How Matt pivoted from mathematics to biology.[11:46] What is the Dog Aging Project?[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.[20:23] Rapamycin vs. sterile inflammation.[23:07] Current thoughts about how the immune system changes as we age.[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).[42:20] Rapamycin and the Dog Aging Project.[45:30] Rapamycin vs. neurodegeneration.[48:21] What studies tell us about rapamycin’s potential to increase lifespan.[51:30] Rapamycin alternatives considered for the Dog Aging Project.[57:05] Urolithin A and spermidine.[59:45] 17 alpha estradiol.[1:01:47] Deprenyl.[1:03:54] NAD precursors.[1:05:52] What is Matt doing to increase his own lifespan/healthspan?[1:09:00] Is time-restricted feeding beneficial for dogs?[1:17:08] Currently, how well (or poorly) funded is longevity research?[1:22:02] Where additional funding in this field would be best leveraged.[1:35:19] Cutting through the hype and snake oil.[1:42:26] Metformin.[1:45:24] NAD infusion vs. natural NAD replenishment.[1:48:16] Sirtuins.[1:52:30] Resveratrol.[2:08:58] Is there a fix to liability in defensive medicine?[2:10:48] Finding better motivations for scientific pursuit.[2:15:48] Longevity scientists worth checking out.[2:17:39] Getting involved with the Dog Aging Project / parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.Specifically, we discuss: Intro (00:00) Aging and disease (03:42) Evolutionary conserved processes and human life span (17:41) Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29) Aging process and the burden of senescence cells (34:06) Keys to a longer, healthier life (45:08) Sleep and exercise (55:38) Calorie restriction, longevity, and prolonged fasting (1:15:23) Protein restriction and its implications (1:32:14) Plant protein vs animal protein (1:43:31) Natural occurring polyphenols and supplements related to longevity (1:53:06) Rapamycin and rapamycin derivatives (2:13:53) Anti-aging compounds (2:29:38) Ethical implications of prolonging the life (2:51:08) Outro (2:57:23) To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.Discover more insights and supporting resources in the full show notes.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary two-week meal plan and high protein Plant Performance recipe book

Welcome to another episode of The Tim Ferriss Show, where it is my job to deconstruct world-class performers to tease out the routines, habits, et cetera that you can apply to your own life. This is a special inbetweenisode, which serves as a recap of the episodes from last month. It features a short clip from each conversation in one place so you can easily jump around to get a feel for the episode and guest.Based on your feedback, this format has been tweaked and improved since the first recap episode. For instance, @hypersundays on Twitter suggested that the bios for each guest can slow the momentum, so we moved all the bios to the end. See it as a teaser. Something to whet your appetite. If you like what you hear, you can of course find the full episodes at tim.blog/podcast. Please enjoy! ***This episode is brought to you by 5-Bullet Friday, my very own email newsletter that every Friday features five bullet points highlighting cool things I’ve found that week, including apps, books, documentaries, gadgets, albums, articles, TV shows, new hacks or tricks, and—of course—all sorts of weird stuff I’ve dug up from around the world.It’s free, it’s always going to be free, and you can subscribe now at tim.blog/friday.***Timestamps:LIV BOEREE: 00:03:14LUIS VON AHN: 00:12:27NOAH FELDMAN: 00:18:58BALAJI SRINIVASAN: 00:24:06DR. MATT KAEBERLEIN: 00:33:38MARK PLOTKIN AND HAMILTON MORRIS: 00:43:39Full episode titles:Liv Boeree, Poker and Life — Core Strategies, Turning $500 into $1.7M, Cage Dancing, Game Theory, and Metaphysical Curiosities (#611)Luis von Ahn, Co-Founder and CEO of Duolingo — How to Be (Truly) Mission-Driven, Monetization Experiments, 10x Growth, Org Chart Iterations for Impacting Metrics, The Intricate Path to an IPO, Best Hiring Practices, Catching Exam Cheaters, The Allure of Toto Toilets, The Future of Duolingo, and How to Stand Out in Your Career (#607)Balaji S. Srinivasan — 5-10-Year Predictions, How to Start a New Country, Society-as-a-Service (SaaS), Bitcoin Maximalism, Memetic Warfare, How Prices Are Born, Moral Flippenings, The One Commandment, and The Power of Missionary over Mercenary (#606)Signal Over Noise with Noah Feldman — The War in Ukraine (Recap and Predictions), The Machiavelli of Maryland, Best Books to Understand Geopolitics, The Battles for Free Speech on Social Media, Metaverse Challenges, and More (#608)The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More (#610)Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary’s Legacy, and More (#605)***For show notes and past guests, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Balaji Srinivasan, Sarah Silverman, Dr. Andrew Huberman, Dr. Michio Kaku, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You just want to look better, feel better, have bigger muscles, tighter skin, and a sexier body you can enjoy and be proud of. The information and narratives floating around on how to achieve that are all over the place, and understanding how to discern what the takeaway action is going to be for you to achieve results is really what you need.Matt Kaeberlein, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project, is a biologist best known for his research on evolutionarily conserved mechanisms of aging.When you’re doing your own research into what things you can be doing to optimize your health and lifespan, Matt warns that you’ll need to be careful of research studies with narratives that lean one-sided.Some of the key ideas Matt and Tom discuss in this episode around anti-aging that will perk up your ears are:Why Matt calls BS on “Reverse-Aging”What the drug Rapamycin has the potential to do for long term healthWhat metrics should we be measuring for good health and anti-agingWith all the years of experience from Matt Kaeberlein as a biologist specializing in anti-aging, he confirms that exercise and nutrition are as effective as exogenous drugs such as Rapamycin.Are we busy trying to create complicated solutions to anti-aging, longevity and health that plain old boring nutrition and exercise can take care of already?Check out Matt Kaeberlein’s Dog Aging Project: https://dogagingproject.org/QUOTES:“We know things like rapamycin, [...] can reverse some of the functional declines that go along with aging.”“I’m not so sure that exercise and nutrition are fundamentally different from rapamycin. Exercise hits the hallmarks of aging, it affects biological aging.”Follow Matt Kaeberlein:Website: https://kaeberlein.org/Twitter: https://twitter.com/mkaeberleinInstagram: https://www.instagram.com/dogagingproject/SPONSORS:Get 5 free AG1 Travel Packs and a FREE 1 year supply of Vitamin D with your first purchase at https://bit.ly/AG1Impact.Sign up for a one-dollar-per-month trial period at https://bit.ly/ShopifyImpact and supercharge your business!Get FREE GROUND BEEF FOR LIFE plus $20 off your first box at https://bit.ly/ButcherBoxImpact.Get 55% off at https://bit.ly/BabbelImpact and learn a new language today!Are You Ready for EXTRA Impact?If you’re ready to find true fulfillment, strengthen your focus, and ignite your true potential, the Impact Theory subscription was created just for you.This is not for the faint of heart. This is for those who dare to learn obsessively, every day, day after day.Subscription Benefits: Unlock the gates to a treasure trove of wisdom from inspiring guests like Andrew Huberman, Mel Robbins, Hal Elrod, Matthew McConaughey, and many, many, more New episodes delivered ad-free Exclusive access to Tom’s AMAs, keynote speeches, and suggestions from his personal reading list You’ll also get access to an 5 additional podcasts with hundreds of archived Impact Theory episodes, meticulously curated into themed playlists covering health, mindset, business, relationships, and more: Legendary Mindset: Mindset & Self-Improvement Money Mindset: Business & Finance Relationship Theory: Relationships Health Theory: Mental & Physical Health Power Ups: Weekly Doses of Short Motivational Quotes  Subscribe on Apple Podcasts: https://apple.co/3PCvJazSubscribe on all other platforms (Google Podcasts, Spotify, Castro, Downcast, Overcast, Pocket Casts, Podcast Addict, Podcast Republic, Podkicker, and more) : https://impacttheorynetwork.supercast.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Explore how dogs and humans can enhance longevity with diet, stem cell therapy breakthroughs, and rapamycin trials. Learn about the correlation between diet and health span, the impact of rapamycin on aging, and the role of AI in data analysis. Discover the innovative use of retinal scans, webcam tech, and the worm bot in longevity research.

Matt Kaeberlein is globally recognized for his research on the biology of aging and is a previous guest on The Drive. In this episode, Matt defines aging, the relationship between aging, chronic inflammation, and the immune system, and talks extensively about the most exciting molecules for extending lifespan. He discusses the current state of the literature of testing rapamycin (and rapalogs) in animals and humans, including Matt’s Dog Aging Project, and provides insights into how we can improve future trials by conceptualizing risk, choosing better endpoints, and working with regulators to approve such trials. He also examines the connection between aging and periodontal disease, biomarkers of aging, and epigenetic clocks. Finally, they explore some of the biological pathways involved in aging, including mTOR and its complexes, sirtuins, NAD, and NAD precursors. We discuss: The various definitions of aging [3:25]; The relationship between disease and the biology of aging [16:15]; Potential for lifespan extension when targeting diseases compared to targeting biological aging [22:45]; Rapamycin as a longevity agent and the challenges of targeting the biology of aging with molecules [32:45]; Human studies using rapalogs for enhanced immune function [39:30]; The role of inflammation in functional declines and diseases of aging [50:45]; Study showing rapalogs may improve the immune response to a vaccine [56:15]; Roadblocks to studying gero-protective molecules in humans [1:01:30]; Potential benefits of rapamycin for age-related diseases—periodontal, reproductive function, and more [1:12:15]; Debating the ideal length and frequency of rapamycin treatment for various indications like inflammation and longevity [1:21:30]; Biomarkers of aging and epigenetic clocks [1:29:15]; Prospects of a test that could calculate biological age [1:37:45]; The Dog Aging Project testing rapamycin in pet dogs [1:42:30]; The role of the mTOR complexes [1:58:30]; mTor inhibitor called Torin2, mitochondrial disease and other potential pathways [2:09:45]; Catalytic inhibitors, sirtuins, and NAD [2:19:15]; NAD precursors: help or hype? [2:28:15]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/MattKaeberlein2  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter is joined by special guest, Dr. Matt Kaeberlein. Together they answer many questions around the field of aging with an emphasis on three specific molecules—NAD, metformin, and rapamycin—and their purported geroprotective qualities. They first discuss aging biomarkers and epigenetic clocks before breaking down the advantages and limitations of the most common experimental models being used today to study aging and pharmacological possibilities for extending lifespan. Next they dive deep into NAD and the much-hyped NAD precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). They compare data from NAD precursors to studies on metformin and rapamycin, assessing how they stack up against each other and using the comparison as an opportunity to illustrate how to make sense of new experimental data and make smart decisions about how to approach future research. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #35 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Logic behind comparing NAD precursors to rapamycin and metformin [3:40]; Aging biomarkers: current state, usefulness, and future promise [7:00]; Epigenetic clocks: definition, use case, and limitations [14:45];   Advantages and limitations of studying aging in non-humans and the strengths and weaknesses of different model systems [26:30]; Aging studies: importance of control lifespans and the problems with reproducibility [34:15]; Intro to NAD, potential role in aging, relationship to sirtuins, and more [48:15]; NAD precursors (NR and NMN): current data [1:10:00]; Human studies with NAD precursors [1:25:45]; Comparing NAD lifespan data to data from metformin and rapamycin [1:28:30]; Defining a “clean drug” and a “dirty drug” [1:38:00]; Reason for the lack of rapamycin studies in humans compared to NAD and metformin [1:41:00]; Ranking the geroprotective molecules in terms of risk and reward [1:48:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube  

Matt Kaeberlein, PhD, a longevity scientist and CEO of Optispan, dives into the cutting-edge world of health span enhancement. He discusses the pivotal roles of mTOR signaling, dietary protein, and exercise in muscle preservation as we age. Kaeberlein explores the potential benefits of rapamycin, spermidine, and NAD precursors for longevity while cautioning against common myths like resveratrol as a magic solution. He also highlights the impact of lifestyle factors—like obesity and alcohol consumption—on overall health and aging.