The Human Upgrade with Dave Asprey
How Dogs Are Going to Make You Live Longer: Rapamycin & Longevity – Matt Kaeberlein : 1145
Mar 19, 2024
In this enlightening discussion, Matt Kaeberlein, CEO of Optispan and a leading researcher in the Dog Aging Project, shares his insights on longevity for both humans and dogs. He discusses the pivotal role of diet in promoting health and how rapamycin may reduce age-related inflammation. The conversation also explores the fascinating interplay between dog health studies and human aging, emphasizing the importance of nutrition and innovative research approaches. Kaeberlein sheds light on exciting advancements in aging science and what they mean for our furry friends and ourselves.
01:22:09
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Quick takeaways
- Rapamycin shows promise in extending lifespan and improving health span in dogs and humans.
- Personal experiences with rapamycin highlight its potential in reducing inflammation and enhancing quality of life.
Deep dives
Rapamycin and Its Effects on Lifespan in Dogs
Rapamycin, a molecule discovered on Easter Island, has shown potential in extending lifespan and improving health span in laboratory animals. Clinical trials in dogs have shown no adverse events at tested doses and have indicated improvements in age-related heart function and reported activity levels. The Triad trial, designed to detect a 9% change in lifespan, targets big dogs aging rapidly to ensure adequate statistical power.
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