
The Human Upgrade with Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Latest episodes

20 snips
Jun 19, 2025 • 1h 5min
The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293
Darin Olien, an environmental health expert and bestselling author, joins for a fascinating discussion on the hidden dangers in our daily lives. They explore how rare plant compounds can enhance longevity and the perils of common toxins like PFAS and microplastics. Olien reveals why tap water can be hazardous and offers filtration solutions. The conversation emphasizes the importance of detoxing and improving indoor air quality to truly upgrade our health habits. Together, they stress the need for informed dietary choices and conscious living to combat environmental threats.

78 snips
Jun 17, 2025 • 1h 9min
The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel : 1292
In this insightful discussion, Amitay Eshel, a biohacking skincare pioneer and founder of Young Goose, reveals how popular anti-aging products might actually accelerate skin aging. He breaks down the damaging effects of harsh exfoliants and blue light therapies on skin health, emphasizing the importance of supporting mitochondrial function and cellular repair. Amitay also explores the fascinating connections between skin aging, brain health, and innovative strategies like red-light therapy, guiding listeners towards smarter, scientifically-backed skincare choices.

108 snips
Jun 13, 2025 • 43min
Why Most Supplements Are a WASTE of Money (And What Actually Works) : 1291
Jeff Boyd, founder of MTE and a pioneer in performance supplements, joins the conversation to debunk myths around supplements. He reveals why most are ineffective and how to identify marketing gimmicks. Jeff shares insights on the science of nootropics and adaptogens, along with strategies to optimize energy and mental clarity without caffeine. They discuss the importance of sleep and nutrition in boosting cognitive function and family dynamics, emphasizing a data-driven approach to wellness. Understand how to reclaim your energy and make smarter choices in supplements.

22 snips
Jun 12, 2025 • 53min
Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290
Rick Doblin, founder of MAPS and an authority in psychedelic research, delves into the revolutionary potential of MDMA-assisted therapy for mental health. He discusses the FDA's regulatory battles and the juxtaposition of pharmaceutical profits against public benefit. The conversation emphasizes the transformative power of psychedelics in emotional resilience and neuroplasticity. With a focus on structured therapy settings, Doblin highlights innovative applications, including couples therapy, and urges a paradigm shift in the approach to psychedelics and trauma healing.

30 snips
Jun 10, 2025 • 1h 6min
Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289
Dr. Josh Axe, a pioneer in functional medicine and co-founder of Ancient Nutrition, sheds light on the surprising dangers of 'healthy' foods for your gut and hormones. He discusses the decline of soil nutrients, the pitfalls of monocropping, and how regenerative farming can rejuvenate both health and the planet. The conversation dives into the impact of environmental factors on hormonal balance, challenges posed by modern diets, and introduces natural alternatives for hormone optimization. Prepare for a fascinating exploration of nutrition that fuses ancient wisdom with cutting-edge science!

37 snips
Jun 5, 2025 • 53min
How 5G Affects Brainwaves (and the New Science to Fix It) : 1288
Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and former T-Mobile VP, dives into the effects of 5G on brainwaves and cognitive function. He discusses groundbreaking EEG research showing how EMF exposure disrupts brain activity. The conversation covers innovative techniques for biohacking and EMF mitigation, emphasizing emerging tools that even skeptics are recognizing. Listeners learn about the benefits for athletes and the potential for enhanced brain health and resilience against high-EMF environments, making this a must-listen for anyone seeking to optimize their mental performance.

79 snips
Jun 3, 2025 • 1h 23min
Mark Sisson: The Japanese Walking Hack That Outperforms 10,000 Steps A Day : 1287
Mark Sisson, bestselling author and primal health pioneer, shares insights on innovative walking techniques that can outperform the traditional 10,000 steps a day. He highlights the benefits of the Japanese walking interval method for longevity and fat burning. Sisson emphasizes the critical connection between foot health and overall well-being, advocating for barefoot shoes and minimal footwear. He reveals how effective movement and training for just 20 minutes a week can enhance performance without compromising mitochondrial health, urging listeners to embrace smarter exercise strategies.

18 snips
May 29, 2025 • 1h 15min
60 Days Alone in Antarctica: Amputation, Frostbite, and Lessons from Extreme Suffering | Akshay Nanavati : 1286
In this engaging conversation, elite adventurer Akshay Nanavati, a Marine Corps veteran and founder of Fearvana, shares his gripping experience of surviving 60 days alone in Antarctica. He reveals how he used extreme suffering as a catalyst for spiritual awakening and peak performance. The discussion dives into the neuroscience of pain, the paradox of joy found in discomfort, and the transformative power of solitude. Akshay's insights on navigating trauma, resilience, and the duality of life's challenges offer profound wisdom, encouraging listeners to embrace both fear and growth.

109 snips
May 27, 2025 • 59min
10-Second Breath Hack to Reset Your Body & Mind | Aaron Alexander : 1285
Aaron Alexander, a human performance coach and creator of The Align Method, shares powerful insights into the art of breathwork. He explains how a simple breathing technique can swiftly reset your nervous system and regulate stress. Alexander highlights the crucial link between jaw alignment, posture, and overall health, revealing how these factors can impact emotional well-being. He also emphasizes the importance of mouth taping for improved sleep and explores the body-mind connection with practical tips for optimizing vitality and personal growth.

27 snips
May 22, 2025 • 59min
Ayurveda Meets Biohacking: 5000-Year-Old Medicine Secrets for Modern Stress | Mona Sharma : 1284
Join Mona Sharma, an Ayurvedic practitioner and wellness expert who blends Vedic traditions with modern science. She shares fascinating insights on ancient health protocols to combat stress and enhance performance. Discover how breathwork and detoxification can rewire the nervous system and promote emotional resilience. Mona discusses the significance of managing chronic stress through self-awareness and practical techniques. Learn how to incorporate Ayurveda’s wisdom into daily routines for optimal health in today’s fast-paced world.