The Human Upgrade with Dave Asprey

Dr. Anurag Singh, Chief Medical Officer of Timeline, discusses revolutionary science in cardiovascular health. He highlights the role of mitochondria in heart failure, especially after menopause. The conversation delves into the benefits of Urolithin A, a potent molecule that rejuvenates mitochondrial function and may reverse markers of cardiac aging. Dr. Singh also shares lifestyle biohacks that can enhance heart resilience and improve overall healthspan, all while promoting endurance and cellular nutrition.

Dr. Brandon Crawford, a neurotherapist and founder of 528 Innovations, discusses how laser therapy can revolutionize mental health and consciousness. He explains how targeted light can rewire brainwaves, aid recovery from conditions like autism and ALS, and even activate the vagus nerve. Listeners will be fascinated by the idea that specific laser frequencies can improve mood and gut-brain communication. Crawford shares his insights on the intersection of emotion, biology, and quantum science, portraying a new approach to mental wellness through innovative light-based therapies.

Zach Bush, MD, a trailblazer in cellular intelligence, reveals how mitochondria can act as conscious messengers rather than mere energy producers. He discusses the symbiotic relationship between our microbiome and health, illustrating how disrupted cellular communication is linked to chronic diseases. The conversation also explores how emotional trauma affects genetic expression and mitochondrial function. Bush emphasizes the importance of restoring connections within ecosystems and the human body for optimal well-being, advocating for a holistic approach to health that embraces ancient wisdom.

Ulrich Dempfle, a German-trained engineer and co-founder of CAROL Bike, introduces a revolutionary workout method called REHIT. This new approach dismantles outdated cardio advice, promoting short, 8-minute sessions that significantly improve VO₂ max and reduce diabetes risk. Dempfle discusses how REHIT outperforms traditional jogging, offers enormous fitness gains, and even benefits perimenopausal women. He also shares insights on personalizing workouts with AI, emphasizing the importance of fun and adherence for lasting fitness results.

Dr. Daniel Pompa, a leader in cellular detox and root-cause healing, discusses the hidden health issues causing chronic fatigue despite normal bloodwork. He reveals how cellular dysfunction, neurotoxicity, and hormone resistance sabotage energy and well-being. The conversation explores the dangers of toxins like glyphosate, the importance of detoxing at a cellular level, and the role of dietary fats in inflammation. Dr. Pompa emphasizes a holistic approach to health, advocating for truly understanding and addressing the root causes over merely treating symptoms.

Sébastien Page, CIO of a major investment firm and author of 'The Psychology of Leadership', discusses how top leaders leverage stress instead of shying away from it. He uncovers why zero stress can lead to burnout and explores the pivotal role of strategic patience in decision-making. Sébastien shares fascinating insights about how losses can fuel mastery, the balance between intuition and analysis, and the importance of kindness over mere niceness in leadership. This conversation is a masterclass in transforming pressure into productivity.

Michael Tiffany, Co-founder and CEO of Fulcra Dynamics, dives deep into the future of personal data ownership alongside fellow innovator Vishakh. They discuss how technologies like Nillion allow secure use of genetic data without compromising privacy. Tiffany reveals the shocking truth about government access to DNA and the revolutionary potential of decentralized networks. The duo explores the concept of a 'cybernetic operating system' and its implications for health freedom, encouraging listeners to reclaim their data in the era of biohacking.

Join Dr. Steven Gundry, a leading heart surgeon and author of The Plant Paradox, as he explores the powerful connection between our gut microbiome and mental health. Discover how gut bacteria can influence your thoughts and cravings, potentially hijacking your brain. Dr. Gundry reveals shocking insights about the effects of antibiotics, glyphosate, and processed foods on gut health. He discusses how specific microbes can lead to addiction and obesity, and offers strategies for rebuilding your gut ecosystem through better dietary choices.

Carolina Reis Oliveira, a longevity researcher and stem cell biologist with a PhD in immunology, joins the conversation to challenge the long-held belief that hair loss is purely genetic. She explains how senescent, or 'zombie' cells, contribute to hair thinning and reveals groundbreaking research on the OS-01 peptide, which can increase hair density by 40% in just six months. The discussion covers the impact of stress, hormones, and the scalp microbiome on hair health, promising innovative solutions for reversing hair loss and regrowing hair.

Olga Khazan, an award-winning journalist from The Atlantic and author of 'Me, But Better,' shares her insights on transforming personality traits. She discusses how to recode your identity, emphasizing that traits like anxiety and neuroticism are not fixed. The conversation covers the surprising connection between gut health and emotional states, the neurobiology of gratitude, and effective strategies for overcoming inner critics. Olga’s personal journey serves as a guide for anyone desiring meaningful change and resilience at any age.