The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
Feb 1, 2026 • 8min
Aging Starts In Your Legs (Here’s The Fix) : 1408
They argue that functional aging begins with weakening legs and discuss why leg muscles and mitochondria are central to early decline. They explain mitophagy, how it falters with age, and why exercise and protein alone can fail after your 40s. They cover how a compound called urolithin A reactivates mitochondrial cleanup, limits of gut production, and clinical studies showing strength improvements over months.
45 snips
Jan 30, 2026 • 1h 4min
The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407
Chris Burres, founder and chief scientist of MyVitalC and an early C60 manufacturer, explains the Nobel Prize molecule that reshaped longevity research. He traces its surprising 90% lifespan result in rats, how stable manufacturing made human use possible, and how C60 interacts with mitochondria, sleep, oxidative stress, and athletic recovery. Short timelines for focus, sleep, and systemic effects are discussed.
64 snips
Jan 29, 2026 • 1h 7min
Meet the Governor Who Wants Humans to Become Cyborgs : 1406
Zoltan Istvan, transhumanist author and futurist who ran for California governor, pushes radical human enhancement through tech and policy. He explores classifying aging as a disease, machine integration versus biology, implants and 3D‑printed organs, and using California as a longevity test bed. They also debate regulation, morphological freedom, AI risks, and the ethics of upgrading humanity.
45 snips
Jan 27, 2026 • 1h 2min
Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405
Gabrielle Lyon, physician and muscle-centric medicine pioneer, explains why your glutes are a longevity organ. She covers muscle’s role in metabolism, brain health, and resilience. Topics include protein dosing, mitochondria and performance, intermuscular fat, safe strength training strategies, blood flow restriction, and the risks of GLP-1 drugs without attention to muscle.
31 snips
Jan 25, 2026 • 22min
The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404
They dig into how appetite is driven by gut hormones and why willpower and calorie counting fail. The conversation covers reactivating natural satiety signals with protein, fiber and structured meals. Learn how butyrate from resistant starch can trigger GLP-1 and which starch sources to choose. Practical tips include a slow intro protocol, rebuilding the microbiome, and lifestyle support for gut healing.
32 snips
Jan 23, 2026 • 9min
Biohacking News Weekly Update : 1403
Discover the transformative shift in U.S. dietary policy as real food takes center stage, challenging ultra-processed products. Explore a groundbreaking study where a drug combination significantly extends the lifespan of frail mice, potentially revolutionizing longevity medicine. Learn about innovative tools like ChatGPT Health for tracking your wellness data. Plus, the return of whole milk to school menus sparks debate over nutrition and health for kids. Dive into these engaging discussions for actionable insights on better living!
63 snips
Jan 22, 2026 • 1h 13min
This Brain Trick Feels Like Cheating (Do THIS) : 1402
Dr. David Perlmutter, a board-certified neurologist and bestselling author, delves into the fascinating link between microglial health and brain function. He discusses how mitochondrial conditions impact cognition, emotional regulation, and neurodegeneration. The conversation highlights everyday factors like diet and sleep that influence this dynamic. They explore innovative tools, including GLP-1 drugs and light therapies, to support brain health. The episode also touches on the role of inflammation in impulsivity and the importance of lifestyle choices for optimal brain resilience.
23 snips
Jan 20, 2026 • 43min
Inside the Mind of the Mad Scientist Rewriting Aging : 1401
Dr. Theodore Achacoso, a pioneering physician-scientist in Health Optimization Medicine, shares groundbreaking insights on how cellular stress shapes aging. He explains the critical role of mitochondria in energy and repair, and how interventions like methylene blue can rejuvenate cellular function. The conversation dives into the effects of travel on metabolism, the significance of LDL cholesterol in detoxification, and the balance of fasting and sleep for optimal health. Get ready to rethink aging from the inside out!
44 snips
Jan 18, 2026 • 23min
I Lost 100 Pounds Of Fat By Drinking Fat (Just Do This) : 1400
Discover how a sip of yak butter tea on a Tibetan mountain transformed one person's approach to food and weight loss. Uncover the surprising connection between dietary fats and fat burning, challenging traditional calorie-counting beliefs. Learn practical food swaps for better health, the benefits of intermittent fasting, and why chronic cardio might actually be hindering your progress. Dive into the pivotal role of mitochondria in energy and aging, along with detox strategies to optimize weight loss and overall wellness.
68 snips
Jan 16, 2026 • 46min
The Superbrain Drug Politicians Use To Outsmart Everyone : 1399
In a captivating discussion, David Renteln, Co-founder and CEO of LUCY Nicotine, shares insights on why nicotine, often misunderstood, can actually enhance cognitive performance when used correctly. He explains how absorption speed affects addiction risk and how oral nicotine can boost memory and neuroplasticity. The duo also delves into the benefits of nicotine for learning, the importance of proper dosing, and the future of regulation in harm reduction. Plus, Renteln offers practical tips for integrating nicotine into daily routines and debunks myths surrounding its use.
