The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Episodes
Mentioned books
Aug 22, 2025 • 54min
The Hormone War Dividing Female and Male Longevity : 1318
Teal Swan, a bestselling author and international speaker, explores the complex relationship between hormones and longevity. She reveals how male and female biology diverges, impacting metabolism and brain function. The conversation dives into the effects of birth control on testosterone and how trauma shapes our biology. Listeners learn about biohacking strategies like fasting, sleep optimization, and supplements to balance hormones for better resilience. Teal's insights bridge psychology and biology, offering profound perspectives on personal transformation.
31 snips
Aug 21, 2025 • 1h 7min
The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317
In a fascinating discussion with Dr. Vonda Wright, a double board-certified orthopedic surgeon and sports medicine pioneer, listeners discover how walking speed can predict longevity more accurately than cholesterol. Dr. Wright shares simple at-home tests for biological age and the importance of pelvic floor health, especially after C-sections. She highlights the pivotal role of hormones during perimenopause and offers biohacking tips to boost metabolism and vitality. With insights on strength training and brain health, this talk encourages a proactive approach to aging gracefully.
84 snips
Aug 19, 2025 • 1h 8min
PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316
Dr. Leonard Guarente, an MIT PhD and a leading authority on longevity, shares groundbreaking insights on aging. He explains how NAD+ is crucial for mitochondrial health and how sirtuins can enhance resilience and recovery. They discuss DNA methylation as a measure of biological age and delve into innovative dietary strategies for longevity. With insights on supplements, fasting, and the intriguing relationship between homocysteine and brain health, this conversation is a treasure trove of tips to optimize your longevity journey!
136 snips
Aug 15, 2025 • 60min
Still Fasting in 2025? Here’s How to Make It Work Better : 1315
In this conversation, Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN, unveils groundbreaking techniques for activating stem cells to enhance recovery and performance. He discusses how fasting boosts stem cell effectiveness, the importance of microcirculation, and the synergy of various biohacking tools like PEMF and cold therapy. Drapeau shares practical strategies for nutrition and supplements that drive mitochondrial health and longevity, while addressing how stem cells can revolutionize recovery from injuries, particularly in athletes.
95 snips
Aug 14, 2025 • 52min
How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314
In this discussion with Joe Hudson, a world-renowned executive coach, listeners explore how unresolved emotions hinder decision-making and peak brain performance. Joe shares insights on reprogramming the nervous system and nurturing emotional intelligence for clear, resilient thinking. He delves into somatic awareness and emotional release techniques that enhance energy, focus, and relationships. The conversation emphasizes embracing fear and vulnerability as pathways to authenticity and profound personal transformation in both professional and personal realms.
70 snips
Aug 12, 2025 • 59min
The New Poisons Lurking Around You – Save Your Longevity : 1313
Join environmental health attorney Alan Bell, author of POISONED, as he uncovers the invisible toxins in our homes that harm our health and accelerate aging. He discusses the connection between these chemicals and various health issues, including their impact on metabolism and brain function. Learn about biohacking techniques like detox protocols and how they can protect your longevity. Alan emphasizes the importance of creating safe environments and shares actionable strategies to improve well-being. Discover how hidden dangers affect everyday life and what you can do to fight back.
119 snips
Aug 8, 2025 • 60min
Jim Kwik: What I Take to Biohack Brain Speed and Focus : 1312
Jim Kwik, a world-renowned brain coach and bestselling author of *Limitless*, shares his journey from a traumatic brain injury to becoming a cognitive enhancement expert. He reveals powerful biohacking techniques, including nootropics and personalized nutrition for brain optimization. Topics like the impact of metabolism on brain speed, neuroplasticity through cold therapy and fasting, and the insights of the 'Brain Animal' system for effective learning are also discussed. Jim's unique approach showcases how adversity can lead to remarkable cognitive growth.
81 snips
Aug 7, 2025 • 1h 39min
Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311
Jay Campbell, a leading expert in testosterone optimization and author, joins Hunter Williams, a high-performance coach focused on men’s health. They discuss the surprising benefits of estradiol injections for brain performance and the revolutionary role of peptides like BPC-157 in health optimization. The duo also explores how oral bioregulators can enhance gut-brain signaling and the intricacies of hormone management for longevity. Expect insights on muscle-preserving strategies and the futuristic impact of nootropics on overall wellness!
186 snips
Aug 5, 2025 • 1h 4min
Top 5 Dopamine Boosting Biohacks for Superhuman Energy : 1310
Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health, dives into the world of dopamine and biohacking. He reveals potent compounds like bromantane and ITPP that enhance brain function and energy. Lucas explains how to optimize dopamine for increased motivation and confidence while addressing the intricate relationship between dopamine, testosterone, and masculinity. Listeners learn about the importance of mitochondrial function, hydration strategies, and the pitfalls of common supplements, all aimed at achieving superhuman performance.
98 snips
Aug 1, 2025 • 47min
Protein vs. Plants: The 50g-a-Meal Biohacking Rule : 1309
Join Dr. Gabrielle Lyon, a leader in Muscle-Centric Medicine and nutrition expert, as she shares her insights on the power of protein for longevity and muscle health. She explains why consuming 50 grams of protein per meal is crucial for metabolism and aging. The discussion highlights the importance of leucine and contrasts the benefits of animal versus plant proteins. Dr. Lyon also tackles the pitfalls of plant-based diets for the aging population and emphasizes personalized nutrition strategies to enhance healthspan and performance.
