The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
37 snips
Nov 11, 2025 • 39min
Why Motivation DOESN’T Work | Mental Biohacks : 1361
David Bayer, a transformational coach and author known for his work in personal growth, joins Dave Asprey to discuss the limitations of motivation in achieving true change. They explore how rewiring beliefs and perceptions is essential for sustainable transformation. Key topics include the role of neuroplasticity in shaping reality, how childhood trauma can be transformed into growth energy, and the importance of choosing empowering beliefs to reduce fear. They also emphasize the need for personal sovereignty in directing attention for broader cultural change.
85 snips
Nov 9, 2025 • 9min
New Japanese Walking Hack Burns More Fat Than 10,000 Steps : 1360
Explore a unique Japanese walking technique that can replace the need for 10,000 daily steps and significantly boost fat burning. Learn how this method improves metabolism, lowers stress, and enhances mitochondrial function in just 15–30 minutes. Discover why traditional fitness advice often backfires and how interval walking transforms ordinary strolls into powerful fat-burning sessions. Outdoor elements like sunlight and fresh air further amplify these effects, making walking an underrated fitness powerhouse.
35 snips
Nov 7, 2025 • 12min
Biohacking News Weekly Update : 1359
This week's findings reveal alarming risks associated with long-term melatonin use, linking it to increased heart failure rates. Bryan Johnson's innovative detox experiment shows a significant reduction in microplastics through extreme sauna therapy. Plus, urolithin A emerges as a champion for enhancing immune mitochondrial function. A breakthrough blood test could transform chronic fatigue syndrome diagnoses. Dive into AI modeling of cell behavior and discover how omega-3s can stabilize moods and reduce aggression.
22 snips
Nov 6, 2025 • 1h
The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358
Dr. Daniel Amen, a leading psychiatrist and brain health advocate, shares groundbreaking insights on how emotional and physical pain intersect within the brain. He explains techniques to break the “doom loop” of chronic pain and introduces havening, a method to calm emotions. Daniel reveals how Tylenol can alleviate emotional pain and emphasizes the importance of gut health in pain management. He discusses environmental toxins, the biopsychosocial approach to health, and practical tools to restore brain function and resilience.
79 snips
Nov 4, 2025 • 37min
The New SCIENCE of Energy Healing | Biohacking Updated : 1357
Harry Massey, a British entrepreneur and bioenergetics pioneer, shares his incredible journey from chronic fatigue to health empowerment after discovering energy medicine. He discusses how energy fields and frequency-imprinted remedies can enhance recovery and mitochondrial efficiency. The conversation reveals the capabilities of his innovative GEM wearable, which uses light and PEMF to deliver information for biological optimization. Harry also emphasizes integrating ancient wisdom with modern science, aiming for better emotional resilience and performance.
190 snips
Nov 2, 2025 • 22min
Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356
Explore the intriguing idea that aging might be more about cellular health than simply getting older. Discover the importance of mitochondria in our well-being and how to enhance their function. Learn about REHIT workouts to boost mitochondrial health and the role of healthy fats in fueling your body's energy systems. Fasting techniques can trigger autophagy, your body’s natural cleaning process. Address stress with simple practices like breathwork and morning sunlight to enhance recovery and longevity.
73 snips
Oct 31, 2025 • 45min
What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355
Philipp Samor von Holtzendorff-Fehling, a former telecom executive and CEO of Leela Quantum Tech, shares insights on quantum energy and its role in human performance. He discusses how quantum energy can combat EMF damage, enhance neuroplasticity, and aid self-healing. The conversation dives into practical applications of biofield technology, including improving sleep quality and emotional stability. Philipp reveals studies demonstrating measurable benefits of quantum tech on brain coherence and metabolism, alongside innovative uses in everyday items and water optimization.
195 snips
Oct 30, 2025 • 1h 10min
Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354
Rollin McCraty, Ph.D., is the Director of Research at the HeartMath Institute, specializing in heart-brain coherence and stress regulation. He shares fascinating insights on how heart rate variability (HRV) influences performance and emotional well-being. Discover the benefits of coherence training for resilience and cognitive sharpness, and learn practical heart-focused breathing techniques. They also discuss the surprising effects of Earth's geomagnetic rhythms on our physiology and emotional states, highlighting the interconnectedness of nature and human health.
37 snips
Oct 28, 2025 • 43min
Biohacking Cannabis: The DNA Science of Plant Medicine : 1353
Len May, CEO of EndoDNA and a leader in genomics and medicinal cannabis, talks about revolutionizing health through personalized DNA insights. He reveals how genetics can determine your response to cannabis and psychedelics, enhancing mental health and performance. Throughout the discussion, Len emphasizes the importance of tailored formulations, the role of the endocannabinoid system, and using genetic data to avoid adverse reactions. With compelling anecdotes, he highlights how personalized cannabis strategies can dramatically improve life quality and well-being.
110 snips
Oct 26, 2025 • 18min
This Legal Focus Powder Beats Any Dopamine Detox : 1352
Discover how low brain energy can hinder focus and motivation, instead of just blaming dopamine. Learn about the crucial role of ATP in brain function and how stress and diet might damage your mitochondria. Explore biohacks to boost your energy production, including the surprising benefits of creatine as a powerful nootropic. This affordable supplement can enhance memory and resilience against stress, especially for vegans and those under pressure. Get tips on optimal dosing and hydration to maximize your brain's performance!
