The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Episodes
Mentioned books
Aug 1, 2025 • 47min
Protein vs. Plants: The 50g-a-Meal Biohacking Rule : 1309
Join Dr. Gabrielle Lyon, a leader in Muscle-Centric Medicine and nutrition expert, as she shares her insights on the power of protein for longevity and muscle health. She explains why consuming 50 grams of protein per meal is crucial for metabolism and aging. The discussion highlights the importance of leucine and contrasts the benefits of animal versus plant proteins. Dr. Lyon also tackles the pitfalls of plant-based diets for the aging population and emphasizes personalized nutrition strategies to enhance healthspan and performance.
40 snips
Jul 31, 2025 • 54min
The Air Force Uses This Mind-Bending Sound Biohack — Try It Yourself! : 1308
Rev. Michael Beckwith, a leading voice in spiritual transformation, teams up with Henry Penix, founder of SOAAK Technologies, to explore the power of sound frequencies. They discuss how the Air Force uses sound tech for cognitive performance and mental recovery. Discover how frequency healing can rewire brainwaves, reduce anxiety, and optimize sleep. The duo reveals the link between sound and emotional healing, emphasizing the transformative effects of auditory stimulation on overall well-being and personal growth.
84 snips
Jul 29, 2025 • 59min
How To change ANY Habit In 63 Seconds (No Willpower Needed) : 1307
In this engaging dialogue, cognitive neuroscientist Caroline Leaf shares her groundbreaking insights on rewiring habits in just 63 seconds. She debunks the popular 21-day myth of habit formation, revealing that true change takes 63 days of mindful practice. The discussion dives into the mind-brain connection, highlighting techniques for stopping toxic thoughts and enhancing emotional regulation. Dr. Leaf also emphasizes the profound impact of forgiveness on mental health, offering listeners powerful tools for achieving lasting personal transformation.
10 snips
Jul 25, 2025 • 59min
Who Should Take Herbal Ecstasy Supplements? (The Billion-Dollar Backstory) : 1306
Shaahin Cheyene, a renegade entrepreneur, built a billion-dollar supplement empire with Herbal Ecstasy while still a teenager. He shares the wild story of how he transformed natural compounds into high-performance nootropics. The conversation dives into the implications of ephedra's ban, his clashes with the FDA, and the politics of wellness innovations. Cheyene's journey from a tumultuous youth in Iran to a successful Amazon marketer highlights the challenges of the herbal supplement industry and the power of brain optimization.
92 snips
Jul 24, 2025 • 1h 11min
Boost Brain Power by 25% WITHOUT a Pill (Brain Optimization Secrets) : 1305
In a captivating conversation, global finance expert Richard Conrad unveils how cultural programming impacts brain function and performance. He reveals techniques to enhance cognitive capacity by 25% without drugs, emphasizing the importance of thinking beyond linear logic. The discussion dives into how different cultures perceive truth and time, influencing everything from meditation practices to decision-making. Conrad also explores the balance between personal fulfillment and societal roles, making connections between ancient wisdom and modern health practices.
84 snips
Jul 22, 2025 • 54min
The Biohacking Tool That Will Change the World (Mitochondrial Transfusions) : 1304
In this enlightening discussion, Tom Benson, an inventor and founder of Mitrix, unveils cutting-edge concepts around mitochondrial transfusions that could revolutionize longevity and health. He explains how enhancing mitochondrial function might reverse biological aging and supercharge metabolism. The conversation dives into the critical role of mitochondria in cognitive health, their potential to combat neurodegenerative diseases, and the exciting future of personalized mitochondrial therapies. Tune in to explore this groundbreaking frontier in health innovation!
112 snips
Jul 18, 2025 • 46min
The Fastest-Acting Nootropic I’ve Ever Used : 1303
Nayan Patel, a distinguished pharmacist and formulator with over 20 years in functional medicine, shares groundbreaking insights into topical glutathione delivery. He reveals how this innovative approach can raise intracellular glutathione levels in just 60 seconds, outperforming traditional methods. The conversation dives into glutathione's role in boosting brain health, enhancing emotional resilience, and revolutionizing immunity. With practical applications for detox and performance optimization, this breakthrough could change how we approach longevity and cellular health.
110 snips
Jul 17, 2025 • 54min
Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway) : 1302
Join Dr. Nathan Bryan, a leading expert in nitric oxide biochemistry, as he uncovers the secrets of this crucial molecule that boosts blood flow, metabolism, and cognitive function. Discover why nitric oxide is essential for optimizing health, sexual performance, and longevity. He reveals why most supplements fail and how common lifestyle choices impair its production. Learn about the connection between nitric oxide, diet, and effective strategies to enhance overall well-being, including the potential downsides of statins and the significance of oral health.
81 snips
Jul 15, 2025 • 50min
Easy Oxygen Hacking for Mitochondria (The 15-Minute Upgrade) : 1301
Join Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, as he shares his journey from a near-fatal autoimmune illness to health rejuvenation through oxygen-based biohacking. Discover how just 15 minutes of Exercise with Oxygen Therapy (EWOT) can transform metabolism and combat chronic conditions. He explains how this method activates neuroplasticity and boosts energy levels, making it accessible for both athletes and those facing chronic issues. Tune in for insights on optimizing mitochondrial health and enhancing overall performance!
21 snips
Jul 10, 2025 • 57min
Facelifts, Breast Implants, and the REAL Fix for Wrinkles : 1300
Dr. Victor Urzola, a renowned Costa Rican plastic surgeon, explores the hidden mechanics of aging and skin health. He uncovers how stem cells and advanced procedures can rejuvenate skin, while discussing the risks associated with breast implants, including hormonal and neurological issues. The conversation delves into the science of inflammation related to implants and the benefits of explant surgery. Urzola emphasizes personalized skincare strategies, innovative technologies, and the interplay between cosmetic procedures and overall health.
