The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Mentioned books
15 snips
Oct 21, 2025 • 57min
Why Women’s Joints Are Failing 10x Faster : 1349
Kiran Krishnan, a seasoned research microbiologist and Chief Scientific Officer at Calroy Health Sciences, shares his insights on the critical factors behind joint health decline. He reveals how systemic inflammation and mitochondrial dysfunction contribute to cartilage loss, highlighting that joint pain is often mishandled by conventional treatments. Krishnan discusses innovative solutions, including Cartigenix HP, which utilizes unique boswellia actives and celery seed extracts to combat inflammation. Furthermore, he emphasizes the importance of hormonal changes in midlife women, advocating for proactive measures to maintain joint health.
105 snips
Oct 19, 2025 • 13min
Why You Still Feel Tired And Foggy On A Perfect Diet : 1348
Explore the hidden disruptors that may be affecting your energy and focus, even with a perfect diet. From the impact of EMFs on sleep quality to the dangers of mold in your home, learn why it's crucial to consider your environment. Discover detox hacks to flush out toxins, rebuild essential nutrients, and unleash your mitochondrial power. Plus, practical tips for resetting your circadian rhythm and enhancing digestion, including the benefits of box breathing and gratitude in your daily routine.
69 snips
Oct 17, 2025 • 6min
10 Minute Weekly Biohacking Update : 1347
Explore the future of health as new longevity scores from Elegant Hoopoe track biological aging, with users reporting impressive improvements. Discover how AI is revolutionizing heart diagnostics by speeding up echocardiograms. Learn about the promising results of brain training that rejuvenates neurotransmitters after just ten weeks. Dive into innovations presented at HLTH 2025, featuring digital twins and real-time wearables for hormone and immunity tracking. Plus, find out how single-vial blood tests can streamline health screenings.
91 snips
Oct 16, 2025 • 57min
These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346
Alberto Villoldo, Ph.D., a medical anthropologist and founder of The Four Winds Society, dives into the intersection of ancient healing and modern neuroscience. He discusses how sacred plants activate over 1,100 healing genes to promote brain growth and longevity. Alberto reveals insights on neurogenesis, the transformative powers of psychedelics, and the profound role of mindset in healing. He also emphasizes personal health responsibility and integrating plant wisdom with diet and emotional resilience for optimal well-being.
87 snips
Oct 14, 2025 • 27min
Solo Episode - Nicotine Masterclass (pt. 1) : 1345
Nicotine is often misunderstood, but low-dose use might enhance brain performance and longevity. Controlled intake could improve focus, memory, and neuroplasticity while separating its benefits from the dangers of smoking. The podcast dives into nicotine's mechanisms, exploring how it affects neurotransmitters and metabolic health. Learn about the best delivery methods and why some forms are safer than others. It also addresses potential risks, including dependency and cardiovascular effects, setting the stage for a deeper exploration of this controversial compound.
64 snips
Oct 13, 2025 • 16min
7 Toxic Foods POISONING Your Family's Health (Avoid These!) : 1344
Explore the hidden dangers of common toxic foods that many unknowingly consume daily. Discover how cheap processed seed oils infiltrated our diets and the alarming effects on health, from inflammation to accelerated aging. Uncover the unsettling history behind these oils and their detrimental impact on brain function and vitality. Learn practical tips on healthier cooking options and how to reclaim your health from the food industry’s misleading marketing. This is essential listening for anyone invested in their well-being!
203 snips
Oct 10, 2025 • 60min
The WATER Hack That Boosts Mitochondria by 11%! : 1343
Rowena Gates, co-founder of NanoVi and biophysics expert, discusses groundbreaking biohacking methods to enhance mitochondrial function and cellular repair. She reveals how structured water boosts oxygen efficiency and recovery in just 20 minutes. Topics include measurable improvements in VO₂ max and brain metabolism, as well as comparisons with cold therapy. Rowena also shares insights on how NanoVi complements other wellness strategies, improves mood and fatigue, and enhances resilience in high-performance training and cognitive tasks.
103 snips
Oct 9, 2025 • 50min
Digital Twins: The End of Human Drug Testing for Biohackers : 1342
In this enlightening discussion, Dr. Derya Unutmaz, a world-renowned immunologist at The Jackson Laboratory, shares insights on how AI-powered digital twins can revolutionize drug discovery and potentially eliminate human trials. He highlights the promise of personalized medicine tailored to individual biology for longevity and health. Derya also discusses the role of AGI in transforming medical practice, the need for a re-engineered immune system, and practical strategies for using compounds like metformin and GLP-1 to enhance lifespan.
114 snips
Oct 7, 2025 • 1h 3min
The Hidden Key to Pain-Free Joints (Longevity Tips) : 1341
Dr. Jason Snibbe, a board-certified orthopedic surgeon and sports medicine specialist, shares insights on maintaining healthy joints for longevity. He discusses how weak glutes and poor core stability contribute to joint issues, highlighting the importance of functional movement. Recovery techniques like stretching and cold immersions are vital for joint health. Snibbe also emphasizes wearing supportive shoes and using AI for gait analysis. The conversation wraps up on the future of robotic surgeries and the potential of biologics in orthopedic care.
33 snips
Oct 5, 2025 • 14min
Remote Work Is Making You FATTER (Do THIS to Stop It) : 1340
Working from home may seem liberating, but it disrupts your hormones and metabolism. Discover how posture and lack of movement lead to hormonal imbalances like lower testosterone and heightened cortisol levels. Learn practical posture resets to combat stress and insights on timing meals and incorporating movement to restore insulin sensitivity. Explore the power of light in regulating your hormones and how small environmental changes can boost your energy and libido without extreme dieting. It's time to biohack your remote work experience!
