
The Human Upgrade: Biohacking for Longevity & Performance
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Latest episodes

Jul 10, 2025 • 57min
Facelifts, Breast Implants, and the REAL Fix for Wrinkles : 1300
Dr. Victor Urzola, a renowned Costa Rican plastic surgeon, explores the hidden mechanics of aging and skin health. He uncovers how stem cells and advanced procedures can rejuvenate skin, while discussing the risks associated with breast implants, including hormonal and neurological issues. The conversation delves into the science of inflammation related to implants and the benefits of explant surgery. Urzola emphasizes personalized skincare strategies, innovative technologies, and the interplay between cosmetic procedures and overall health.

81 snips
Jul 8, 2025 • 1h 18min
Superintelligence, Transhumanism & Biohacking in 2027 : 1299
Soren Gordhamer, founder of Wisdom 2.0 and advisor to leaders at OpenAI and Google, joins the conversation to discuss the rapidly approaching era of superintelligence. He emphasizes the need for balancing technology with emotional well-being, offers biohacking strategies for enhancing cognitive health, and reflects on parenting in a tech-centric world. The dialogue also navigates the complexities of human-AI relationships, advocating for community and mindfulness as essential tools for thriving amidst AI advancements.

153 snips
Jul 3, 2025 • 31min
Why I Add Creatine to My Coffee Every Morning (And You Should Too) : 1298
Creatine is more than a bodybuilding supplement; it's a key player in brain optimization and overall health. It boosts cognitive function, enhances memory, and supports mood regulation. Discover its benefits for mitochondrial energy and fetal brain development, as well as its role in longevity. Learn effective dosage strategies and how to enhance absorption with various combinations, including caffeine. This discussion dives deep into the science, debunking myths and revealing effective ways to integrate creatine into your daily routine for optimal performance.

52 snips
Jul 1, 2025 • 57min
Death, Legacy & the Philosophy of Longevity — with Stephen Cave : 1297
Join Stephen Cave, a philosopher and best-selling author, as he dives deep into the philosophical and ethical implications of longevity and death. Explore how biohacking is challenging our understanding of mortality and legacy. Discuss the four immortality narratives and the dangers of mind uploading. Reflect on how AI could reshape humanity’s future—either as a god or destroyer. Unpack the societal consequences of living longer lives, and why embracing mortality might actually enrich our experiences in the here and now.

99 snips
Jun 27, 2025 • 46min
Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly : 1296
Greg Kelly, SVP of Product Development at Qualia Life, is an expert in functional medicine and anti-aging science. In the conversation, he reveals fascinating insights on reversing joint pain, emphasizing that it's often linked to metabolic issues rather than aging. Kelly discusses how gut health impacts joint function and introduces unconventional supplements like tamarind seed extract and eggshell membrane. He also covers the importance of sleep and nutrition in optimizing recovery, alongside cutting-edge techniques for enhancing joint health and longevity.

84 snips
Jun 26, 2025 • 1h 6min
The Ultimate Guide to a Metabolism That Burns Fat Again — with Ben Azadi : 1295
Ben Azadi, a functional health expert and best-selling author, joins to unpack the shocking reality that 93% of people are metabolically unhealthy. They dive into how high insulin levels—not fat—drive chronic diseases, stressing the need for better testing. Listeners will learn to escape the sugar trap, using fasting and sleep optimization to repair metabolic function. The conversation also covers the dangers of seed oils and hidden nutrient deficiencies while offering strategies like potassium balancing and the use of nootropics to enhance metabolic resilience.

87 snips
Jun 24, 2025 • 49min
Why Your Workouts Aren’t Giving You a Summer Body — with Nick Bare : 1294
In this chat, performance-driven entrepreneur and Army veteran Nick Bare shares his insights on why workouts sometimes don’t yield the desired summer body. He emphasizes that consistency is key, not just intensity, and warns against the traps of overtraining. The conversation explores the importance of recovery science, sleep optimization, and the role of mitochondria in energy production. Nick also discusses tackling entrepreneurial stress, balancing ambition with recovery, and leveraging biohacking for enhanced performance and focus.

84 snips
Jun 19, 2025 • 1h 5min
The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293
Darin Olien, an environmental health expert and bestselling author, joins for a fascinating discussion on the hidden dangers in our daily lives. They explore how rare plant compounds can enhance longevity and the perils of common toxins like PFAS and microplastics. Olien reveals why tap water can be hazardous and offers filtration solutions. The conversation emphasizes the importance of detoxing and improving indoor air quality to truly upgrade our health habits. Together, they stress the need for informed dietary choices and conscious living to combat environmental threats.

101 snips
Jun 17, 2025 • 1h 9min
The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel : 1292
In this insightful discussion, Amitay Eshel, a biohacking skincare pioneer and founder of Young Goose, reveals how popular anti-aging products might actually accelerate skin aging. He breaks down the damaging effects of harsh exfoliants and blue light therapies on skin health, emphasizing the importance of supporting mitochondrial function and cellular repair. Amitay also explores the fascinating connections between skin aging, brain health, and innovative strategies like red-light therapy, guiding listeners towards smarter, scientifically-backed skincare choices.

134 snips
Jun 13, 2025 • 43min
Why Most Supplements Are a WASTE of Money (And What Actually Works) : 1291
Jeff Boyd, founder of MTE and a pioneer in performance supplements, joins the conversation to debunk myths around supplements. He reveals why most are ineffective and how to identify marketing gimmicks. Jeff shares insights on the science of nootropics and adaptogens, along with strategies to optimize energy and mental clarity without caffeine. They discuss the importance of sleep and nutrition in boosting cognitive function and family dynamics, emphasizing a data-driven approach to wellness. Understand how to reclaim your energy and make smarter choices in supplements.