The Human Upgrade: Biohacking for Longevity & Performance

Biohacking News Weekly Update : 1403

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Jan 23, 2026

Discover the transformative shift in U.S. dietary policy as real food takes center stage, challenging ultra-processed products. Explore a groundbreaking study where a drug combination significantly extends the lifespan of frail mice, potentially revolutionizing longevity medicine. Learn about innovative tools like ChatGPT Health for tracking your wellness data. Plus, the return of whole milk to school menus sparks debate over nutrition and health for kids. Dive into these engaging discussions for actionable insights on better living!

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INSIGHT

Real Food Becomes Federal Policy

The 2025–2030 Dietary Guidelines center real food and call out ultra-processed foods and added sugar as problems.
This federal shift turns personal nutrition choices into institutional policy affecting schools, SNAP, WIC, and labeling.

INSIGHT

Stacked Interventions Outperform Single Drugs

Combining targeted interventions late in life produced much larger effects than single compounds in frail mice.
Aging likely requires phased, multi-target strategies rather than one magic drug.

ADVICE

Phase Your Longevity Strategy

Stop building random supplement piles and plan interventions in phases: reduce damage, support repair, then maintain function.
Track outcomes and wait for human combination data before assuming broad benefits.

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This episode covers:

• Real Food Reset in U.S. Dietary Policy

The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they shape what eventually shows up on labels and in public institutions. He also shares how biohackers can use this shift as leverage to push for better food environments in schools, workplaces, and hospitals.

-Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health

• Drug Combo Extends Lifespan of Frail Old Mice by 73%

A new aging study found that combining oxytocin with a compound called A5i extended the remaining lifespan of frail elderly male mice by 73%, while also improving function and tissue health. Dave explains why this is a big signal for the future of longevity medicine: stacking targeted interventions can outperform single compounds, especially when you start late in life. He also explains what to do with the idea right now: stop building random “everything stacks” and start thinking in phases, tracking outcomes, and waiting for real human combo data.

-Source: https://www.futura-sciences.com/en/study-finds-drug-combo-could-slow-aging-and-increase-lifespan-by-73_23229/

• ChatGPT Health Turns Your Data Into a Health OS

OpenAI launched ChatGPT Health, a dedicated health experience that lets you securely connect medical records and wellness apps like Apple Health and MyFitnessPal, so you can summarize visits, interpret labs, and prepare better questions for your doctor. Dave explains why this is a turning point for quantified self and protocol building: it reduces the friction of pulling data from five different places, and it makes pattern-finding accessible to nontechnical people. He also shares how to use it like a pro: clean inputs, smarter questions, and better doctor conversations.

-Source: https://openai.com/index/introducing-chatgpt-health/

• Whole Milk Is Back in Schools

The Whole Milk for Healthy Kids Act restores whole and reduced-fat milk options in schools, aligning school nutrition rules with the updated dietary guidelines that no longer treat full-fat dairy like a default villain. Dave breaks down why this matters for child healthspan: satiety and nutrient density drive behavior, learning, and metabolic stability. He also explains why this is a real-world policy experiment worth watching across school districts, and how it can open the door for bigger institutional upgrades like better protein and fewer ultra processed items.

-Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/14/whole-milk-back-president-trump-signs-whole-milk-healthy-kids-act

• Tirzepatide Trial Targets Biological Age With Aging Clocks

A registered clinical trial titled Tirzepatide to Slow Biological Aging is using multiple DNA methylation aging clocks as primary endpoints, along with functional metrics like grip strength and a 6-minute walk test. Dave explains why this is a big maturity step for longevity science: instead of assuming metabolic improvement equals slower aging, this study is measuring biological age directly, across multiple clocks, with performance outcomes. He also shares the practical lesson for biohackers: stop relying on one favorite metric and start thinking in panels, function, and durability of results.

-Source: https://clinicaltrials.gov/study/NCT07220473

All source links provided for direct access to the original research and reporting.

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want practical strategies rooted in cutting-edge science. Host Dave Asprey translates emerging research into actionable upgrades for your biology, from metabolism and food policy to AI-driven tracking, institutional nutrition, and biological aging measurement.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: Dietary Guidelines for Americans 2025-2030, real food policy reset, ultra processed foods policy, added sugar limits, sugary drinks guidelines, school lunch nutrition policy, SNAP WIC nutrition impact, USDA HHS dietary guidelines 2026, whole food protein guidelines, full fat dairy guidelines, oxytocin aging study, A5i lifespan extension, frail elderly mice lifespan 73 percent, combination longevity therapies, aging intervention synergy, staged longevity protocols, functional aging biomarkers, ChatGPT Health launch, OpenAI health records AI, Apple Health ChatGPT integration, MyFitnessPal ChatGPT integration, AI lab interpretation, AI doctor visit summary, quantified self AI tools, Whole Milk for Healthy Kids Act, whole milk back in schools, school dairy policy change, child satiety nutrition, school meal regulations USDA, tirzepatide biological aging trial, GLP-1 GIP longevity, epigenetic aging clocks trial, DNAmAge PhenoAge GrimAge DunedinPACE, grip strength aging endpoint, 6 minute walk aging endpoint, biological age measurement, longevity clinical trial endpoints, biohacking news update, longevity policy shifts, metabolic health upgrades

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