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The Peter Attia Drive

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

Sep 25, 2023
In this engaging discussion, world-leading experts David Sabatini and Matt Kaeberlein dive into the intriguing world of rapamycin, a molecule known for its longevity potential. They share the fascinating history of rapamycin's discovery and its transformation from an immunosuppressant to a geroprotective agent. The conversation addresses crucial questions about its dosing and timing in humans, while examining groundbreaking studies on lifespan extension in mice. Listeners will also learn about the nuances of mTOR's role in aging and the potential implications for future age-related therapies.
02:50:40

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Quick takeaways

  • Rapamycin binds to FKBP and forms a complex with mTOR, a central regulator of biological processes.
  • Rapamycin inhibits mTORC1 and partially inhibits mTORC2, impacting lifespan and health span.

Deep dives

The Discovery of Rapamycin and the Role of mTOR

The podcast episode discusses the discovery of Rapamycin and the role of mTOR in longevity research. Rapamycin, a unique drug, binds to a protein called FKBP and then brings it in close proximity to mTOR, forming an important complex. mTOR, which stands for mechanistic target of rapamycin, is a protein that plays a central role in nutrient sensing and regulates various cellular processes. The episode explores how mTOR works and its connection to the availability of nutrients in the environment. The mTOR protein exists in different complexes, such as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which have distinct functions. Rapamycin inhibits mTORC1 and, over time, partially inhibits mTORC2. The effects of rapamycin on lifespan and health span are still being studied, and there is ongoing research to understand the mechanisms behind its benefits.

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