In this engaging discussion, world-leading experts David Sabatini and Matt Kaeberlein dive into the intriguing world of rapamycin, a molecule known for its longevity potential. They share the fascinating history of rapamycin's discovery and its transformation from an immunosuppressant to a geroprotective agent. The conversation addresses crucial questions about its dosing and timing in humans, while examining groundbreaking studies on lifespan extension in mice. Listeners will also learn about the nuances of mTOR's role in aging and the potential implications for future age-related therapies.