The Peter Attia Drive

Charles Duhigg, a Pulitzer Prize-winning journalist and best-selling author, delves into the fascinating science of habit formation. He discusses how cue-routine-reward loops drive our daily actions and stresses the power of positive reinforcement over punishment. The conversation covers how environments shape behavior, the role of social accountability, and effective strategies for teaching kids good habits. Duhigg also explores how cognitive routines boost productivity and the potential of AI in facilitating lasting habit change.

Eric Verdin, M.D., a leading physician-scientist and CEO of the Buck Institute for Research on Aging, dives deep into the complexities of aging. He discusses how metabolic and immune system dysfunctions influence lifespan, focusing on NAD's declining levels and promising longevity interventions like rapamycin. The conversation also delves into practical strategies for maintaining metabolic health, including diet and exercise, while emphasizing the importance of advancing biomarker research to personalize aging care. Verdin's insights shed light on the critical connections between metabolism, immunity, and aging.

In this engaging discussion, Peter explores hormone replacement therapy and its impact on women's health. He delves into male and female fertility, revealing strategies for optimization and the complexities of conception. The podcast also tackles the biology of aging and effective skin rejuvenation techniques. A thought-provoking examination of life lessons from the dying invites listeners to reflect on mortality while maintaining well-being. Plus, there's an interesting look at how bike seat choices can affect health and fertility.

Brian Kennedy, a distinguished biologist and director of the Center for Healthy Longevity, shares groundbreaking insights on aging research. He discusses exciting human trials of rapamycin, revealing how dosing and lifestyle can influence outcomes. Kennedy presents two innovative aging models and critiques traditional biomarker limitations. He explores potential compounds like alpha-ketoglutarate and urolithin A, while emphasizing the crucial role of lifestyle interventions such as strength training in promoting healthspan and longevity.

In a lively AMA, Peter delves into key topics like brain health and exercise strategies. He reveals how lifestyle choices can alleviate dementia risks by addressing metabolic health. Learn about effective exercise techniques, including zone 2 training and VO₂ max intervals, and the importance of light movement post-meal. Discover tips for managing body composition, including protein goals and overcoming 'slow metabolisms.' This insightful discussion blends science with practical advice for enhancing cognitive and physical well-being.

Dive into the essentials of bone health, covering everything from its structure to the crucial role of nutrition and exercise. Discover the alarming statistics around falls and hip fractures in older adults and the differences between osteopenia and osteoporosis. Learn how medications and lifestyle choices, like smoking, impact bone density. Hear strategies for maintaining bone strength during periods of inactivity, including the significance of DEXA scans and early screenings. It's a deep exploration of how proactive measures can lead to healthier bones throughout life.

Tanuj Nakra, a triple board certified facial plastic surgeon, and Suzan Obagi, a double board certified dermatologist, dive into the science of aging and skin health. They discuss the biological factors driving facial aging, the ethical responsibilities of physicians in cosmetic procedures, and the psychological impact of beauty standards shaped by social media. The duo shares practical skincare tips, emphasizing the importance of preventive measures like sunscreen and retinoids, while also unraveling the complexities of cosmetic interventions and patient consultations.

BJ Miller, a hospice physician and co-founder of Mettle Health, and Bridget Sumser, an expert social worker in serious illness, discuss profound insights from their work in end-of-life care. They explore the emotional and physical realities of dying, the importance of candid conversations about mortality, and how many await hospice care too late. With reflections on fear, forgiveness, and how dying can teach the living to embrace life more fully, they emphasize the transformative potential of understanding our mortality.

This discussion dives into the evolving landscape of fasting, examining its types and health effects. Key benefits like improved body composition, metabolic health, and potential disease prevention are highlighted. The importance of adapting scientific opinions in medicine is emphasized, alongside a practical framework for fasting. Various methods such as intermittent and alternate day fasting are explored, shedding light on their protocols and historical perspectives. The episode balances science with personal insights, creating a thought-provoking dialogue.

In this insightful discussion, Dr. Paula Amato, a leading expert in reproductive endocrinology, dives into the complexities of female fertility. She explains how hormonal changes regulate the menstrual cycle, and why both partners should be evaluated in infertility cases. The conversation reveals the impact of age and lifestyle on reproductive health, while exploring advances in IVF, including egg freezing and genetic testing. Dr. Amato also addresses PCOS treatment options and highlights the need for early intervention to enhance fertility prospects.