Tom Dayspring, a leading expert in clinical lipidology, dives deep into the intricacies of atherosclerotic cardiovascular disease (ASCVD), a major global health concern. He explains how ASCVD develops silently over decades, emphasizing the importance of early detection. Dayspring discusses the critical role of apolipoprotein B (apoB) and the often-overlooked risk factors, including insulin resistance and kidney health. Additionally, he explores how cholesterol impacts brain health, debunking myths about statins, and highlights the significance of dietary choices in managing cardiovascular risk.

In this enlightening discussion, aging experts Steven Austad, Richard Miller, and Matt Kaeberlein delve into the science of aging. They explore the connection between healthspan and lifespan, emphasizing effective interventions like rapamycin and senolytics. The panel critiques the funding challenges in aging research and advocates for more focus on geroscience. Additionally, they examine the complexities of biological age measurements and the potential of GLP-1 receptor agonists in promoting longevity. Packed with humor, insights, and scientific rigor, this conversation is a must-listen!

In a captivating AMA, Peter delves into the pressing issue of microplastics and various plastic-associated chemicals like PFAS and BPA. He discusses their alarming prevalence in our environment and the potential health risks they pose. With insightful definitions and research findings, he breaks down how we encounter these substances daily and emphasizes the importance of understanding genuine risks versus exaggerated claims. Practical strategies for minimizing exposure are also highlighted, empowering listeners to make informed choices.

Join Olav Aleksander Bu, an acclaimed sports scientist and endurance coach, as he dives into optimizing endurance performance. He reveals the importance of key metrics like VO2 max and lactate threshold in tailoring training. Olav also discusses the impact of nutrition on performance, highlighting innovative carbohydrate strategies and supplements like beetroot for endurance. The conversation touches on how AI is reshaping performance analysis, providing athletes with real-time insights to enhance their training. Prepare for an enlightening journey into endurance sports!

Trenna Sutcliffe, a developmental behavioral pediatrician and founder of the Sutcliffe Clinic, discusses her journey in pediatric care and her expertise in autism, ADHD, and anxiety. She delves into the evolving diagnostic criteria for autism and the rise in its prevalence. Trenna emphasizes the importance of personalized treatment plans and explores the overlap of these conditions. She highlights unique strengths in children with autism while advocating for a holistic approach that bridges healthcare and education to better support families.

James Clear, bestselling author of Atomic Habits, dives deep into the intricacies of habit formation and behavioral change. He discusses the evolutionary aspects of habits, the impact of immediate feedback, and how genetics influence our work ethic. Clear emphasizes the importance of shifting from goals to systems and how identity shapes our habits. He also introduces his 'Four Laws of Behavioral Change' and shares actionable strategies for cultivating perseverance, transforming identities, and breaking bad habits through community and accountability.

In a lively AMA session, Peter dives into crucial health topics like the power of grip strength and effective training methods. He discusses the underestimated role of exercise in weight loss, emphasizing caloric restriction instead. Listeners discover strategies for maintaining fitness while traveling and the importance of strength training, particularly for women. Insights into key health biomarkers and exciting longevity research offer new perspectives. The conversation wraps up with tips on building good habits and a peek into Peter’s reading list.

Dive into the fascinating world of nutrition, where the myth of a 'best diet' is explored and debunked. Discover the complexities of nutrition science, the intriguing relationship between nutrition and exercise, and the individuality of dietary responses. Learn practical tips for building a sustainable diet tailored to your health needs. Plus, understand key health metrics to monitor and the essential role of protein in your meals. It's not just about what you eat; it's about how it fits into your unique lifestyle!

Dr. Saum Sutaria, Chairman and CEO of Tenet Healthcare, offers keen insights into the U.S. healthcare system. He breaks down the complexities of private insurance, Medicare, and Medicaid, while addressing the daunting issue of drug pricing. The discussion touches on the economic impact of healthcare costs and the urgent need for reforms. Sutaria highlights how innovation distinguishes U.S. healthcare, examining potential strategies to improve access, quality, and affordability amid rising expenses.

Bill Perkins, a successful hedge fund manager and author of "Die With Zero," dives into the importance of maximizing life fulfillment over wealth accumulation. He argues people are often over-saving and under-living, stressing the need for memorable experiences. Bill shares insights on navigating risks, the relationship between time and money, and the idea of proactive generosity. He encourages listeners to rethink traditional life optimization, advocating for meaningful choices that enhance personal satisfaction and shared experiences.