The Peter Attia Drive

Dominic D'Agostino, Ph.D., is a leading neuroscientist specializing in metabolic therapies like ketogenic diets and hyperbaric oxygen. He delves into nutritional versus supplemental ketosis and offers practical tips to achieve ketosis effectively. The discussion covers the ketogenic diet's impact on weight loss and neurodegenerative diseases such as cancer and Alzheimer's. Additionally, Dominic explores exogenous ketones and their role in cognitive enhancement, while revealing insights on common mistakes and the benefits of hyperbaric oxygen therapy for brain injuries.

Carole Hooven, a human evolutionary biologist and former Harvard lecturer, dives deep into the fascinating world of testosterone and its impact on male development and behavior. She explains how prenatal testosterone influences brain development and lifelong behavioral patterns, highlighting unique aggression styles and play behaviors. Carole shares insights on the implications of modern society on male aggression, the necessity of testosterone therapy, and her own experience with hormone therapy. She also discusses her upcoming book on masculinity and cultural narratives.

Walter Green, a philanthropist and founder of the Say It Now movement, shares transformative insights from his life and work. He emphasizes the importance of gratitude, urging people to express appreciation to loved ones before it's too late. Walter discusses his challenging childhood, the lessons learned from mortality, and the concept of 'finishing strong.' He also offers practical advice on intentional living, defining success, and setting boundaries to prioritize meaningful relationships. His journeys of gratitude culminate in heartfelt tributes to friends, inspiring others to do the same.

Dr. Antonio Bianco, a renowned physician-scientist and former President of the American Thyroid Association, dives deep into thyroid physiology. He discusses the complex roles of deiodinase enzymes in regulating thyroid hormones and their implications for patient care. The conversation highlights the inadequacy of conventional TSH testing, the impact of genetics on thyroid function, and the ongoing debates over treatment methods for hypothyroidism. Bianco also shares insights into why patients may feel unwell despite 'normal' lab results and the need for personalized treatment approaches.

Dive into the surprising science of dietary fiber! Discover the distinct roles of soluble and insoluble fibers in digestion and weight management. Learn why not all fibers are created equal and how cooking influences resistant starch. Peter Attia challenges traditional beliefs about fiber and offers evidence-based insights on its true health benefits, including its impact on glycemic control and cardiovascular risk. Get ready for a personalized approach to maximizing your dietary fiber intake!

Dr. Sally Greenwald, an OB-GYN specializing in women's sexual health, delves into the intricate world of female sexual wellness. She discusses the importance of sexual health for overall well-being, exploring the physiology behind desire and arousal. Highlights include navigating the orgasm gap, practical strategies to enhance intimacy, and the impact of hormones during perimenopause. Sally also addresses common misconceptions, effective communication with partners, and the latest in contraceptive and hormone therapy options, providing vital insights for women and their partners.

This discussion dives into the essentials of longevity, emphasizing the interplay of lifespan and healthspan. Key topics include the evolution of medicine towards preventive care, major death causes like ASCVD and cancer, and strategies for prevention. Peter emphasizes the impact of exercise, nutrition, and sleep on extending vitality. He presents a practical toolkit of five key areas to focus on, encouraging all ages to embrace steps toward better health. Emotional well-being is highlighted as fundamental, reminding listeners that it's never too late to start.

In this engaging AMA, Peter explores the effectiveness of various longevity drugs, classifying them using a unique scale from proven to nonsense. He dives into the potential benefits of GLP-1 receptor agonists and discusses the role of low-dose aspirin in cardiovascular health. Muscle mass improvement strategies also take center stage, focusing on optimal protein intake and innovative gene therapy methods. Listeners gain insights into today's hottest health interventions through a clear, evidence-based lens.

Rhonda Patrick, Ph.D., a renowned scientist and health educator, dives into the crucial role of protein for muscle preservation and longevity. She argues that current protein intake recommendations are too low and suggests a significant increase to maintain health as we age. The discussion expands to the benefits of creatine, highlighting its impact on muscle, brain health, and performance, especially for vegetarians and adolescents. Rhonda also explores the science of sauna use, revealing its cardiovascular benefits and the potential neuroprotective effects of heat exposure.

David Allison, Director of the Children's Nutrition Research Center and notable obesity researcher, dives into the complex world of protein consumption. He addresses the historical demonization of macronutrients, particularly protein, and critiques the RDA as insufficient for modern health needs. Explaining the lack of compelling evidence against higher protein intake, he emphasizes its benefits for muscle and recovery. David also discusses the challenges of nutrition research, focusing on transparency and the role of processed foods in diets, suggesting a need for new approaches to tackle obesity.