Dr. Saum Sutaria, Chairman and CEO of Tenet Healthcare, offers keen insights into the U.S. healthcare system. He breaks down the complexities of private insurance, Medicare, and Medicaid, while addressing the daunting issue of drug pricing. The discussion touches on the economic impact of healthcare costs and the urgent need for reforms. Sutaria highlights how innovation distinguishes U.S. healthcare, examining potential strategies to improve access, quality, and affordability amid rising expenses.

Bill Perkins, a successful hedge fund manager and author of "Die With Zero," dives into the importance of maximizing life fulfillment over wealth accumulation. He argues people are often over-saving and under-living, stressing the need for memorable experiences. Bill shares insights on navigating risks, the relationship between time and money, and the idea of proactive generosity. He encourages listeners to rethink traditional life optimization, advocating for meaningful choices that enhance personal satisfaction and shared experiences.

In this insightful discussion, the focus is on red light therapy and its burgeoning popularity. The host unpacks its basic science and unique penetration abilities, shedding light on various health applications. Key topics include its potential benefits for skin health, wound healing, and aging. The biochemical impact on mitochondrial function is analyzed, emphasizing increased ATP production. A comprehensive look at the therapy’s limitations and effectiveness against chronic issues rounds out the conversation, making it a thought-provoking exploration.

Explore the fascinating world of dopamine and addiction, uncovering how genetics and environment shape behaviors. Dive into the promising future of CRISPR gene editing and its implications for health. Learn how to build strong bones throughout life, and discover the intriguing effects of calorie restriction on longevity. Plus, gain insights on testosterone therapy and its safety concerning prostate cancer. Personal anecdotes and practical health adjustments add a relatable twist to these compelling discussions.

Eric Ravussin, a leading expert on obesity and metabolism, discusses his groundbreaking research on energy expenditure and its influence on aging. He delves into caloric restriction and its health benefits, including insights from the CALERIE study. The episode explores the complexities of measuring energy balance and appetite regulation, highlighting the impact of hormones and dietary habits. Ravussin also examines the potential of GLP-1 agonists and the future of metabolic research through technology and AI advancements.

Feng Zhang, a groundbreaking professor of neuroscience at MIT and a leader in gene editing, discusses his pioneering work with CRISPR technology. He explores the revolutionary journey of CRISPR, from its discovery to its potential in treating genetic diseases like sickle cell anemia. Zhang also addresses the ethical debates surrounding gene editing, particularly concerning germline modifications. He shares insights from his personal journey, the impact of mentorship, and the future potential of genetic medicine, highlighting both challenges and innovative solutions in the field.

Belinda Beck, Ph.D., a leading authority in exercise physiology and founder of The Bone Clinic, shares invaluable insights on bone health. She discusses how childhood nutrition and activity set the stage for strong bones. Belinda emphasizes the importance of resistance training and essential nutrients to combat osteoporosis. She also dives into managing bone health through various sports and highlights the critical role of physical activity throughout life. With practical tips for parents, she empowers listeners to optimize bone density for themselves and their children.

Anna Lembke, M.D., Chief of the Stanford Addiction Medicine Clinic and author of 'Dopamine Nation,' delves into the neurobiology of addiction. She explains dopamine's pivotal role and discusses risk factors influencing addiction in younger generations. Lembke shares her insights on healthy coping mechanisms like cold exposure and the importance of support systems in recovery. She also highlights the dual nature of cannabis and the societal implications of behavioral addictions, providing a comprehensive framework for understanding and treating addiction.

Nick Stenson, co-host and health enthusiast, joins the conversation on the rising trend of GLP-1 agonists, including Ozempic and Mounjaro, originally developed for diabetes. They dive into the drugs' efficacy, safety profiles, and surprising side effects, especially when discontinued. The duo also discusses how resistance training can affect weight loss journeys with these medications. Plus, insights on the role of compounding pharmacies and a glimpse into promising treatments on the horizon make for a captivating and informative discussion.

Julia Wattacheril, a liver health expert, discusses noninvasive diagnostic methods and strategies to boost liver wellness. Joel Jamieson, a heart rate variability specialist, shares practical tools to optimize training and overall health. Zak Kohane, an authority on AI in medicine, explores the transformative potential of technology in healthcare. Peter Attia reflects on valuable behavioral changes inspired by these enlightening conversations, revealing insights into liver health and the role of heart rate variability in training.