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#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

The Peter Attia Drive

CHAPTER

Decoding mTOR: Amino Acids and Muscle Dynamics

This chapter explores the groundbreaking research surrounding mTOR and its interaction with amino acids, particularly leucine and arginine. The discussion highlights the complex relationship between mTOR activity, muscle growth, and aging, revealing the nuances of how nutrients influence cellular signaling. Furthermore, the speakers examine the contrasting roles of rapamycin and metformin in muscle health, raising questions about their effects on aging and exercise in humans.

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