10min chapter

The Peter Attia Drive cover image

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

The Peter Attia Drive

CHAPTER

Rapamycin and Reproductive Aging

This chapter explores the effects of rapamycin on reproductive aging in both male and female mice, highlighting its potential to delay ovarian aging while adversely affecting spermatogenesis in males. It emphasizes the need for further research into rapamycin's impact on anti-malarian hormone levels, particularly for women with ovarian issues, and discusses challenges in conducting clinical trials. The chapter also touches on broader themes of drug development and fundamental questions about aging, setting the stage for future discussions.

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