The Tim Ferriss Show

#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

Jul 27, 2022

Dr. Matt Kaeberlein, a leading researcher on aging from the University of Washington, dives into groundbreaking insights about longevity. He discusses the Dog Aging Project, revealing how canine studies can inform human health. The conversation highlights promising compounds like rapamycin and metformin and their role in extending healthspan. Kaeberlein also shares his personal experiences with aging research, dietary strategies for dogs, and the need for innovative funding in the pursuit of longevity. Tune in for a fascinating look at the future of aging!

02:27:44

Episode guests

Matt Kaeberlein

Highlights

AI Chapters

Episode notes

Develop the Best Model and Seek Weaknesses

01:25

Eight weeks of rapamycin treatment reverses periodontal disease

01:22

Boosting Autophagy for Anti-Aging Benefits

01:19

Immune System and Aging

01:34

Intro

5min

Understanding the Biology of Aging

4min

Exploring Aging: A Journey in Biomedical Research

8min

Exploring Rapamycin and Immune Aging

25min

Exploring Canine Longevity: The Dog Aging Project and Rapamycin Research

4min

Rapamycin and Aging: Insights into Brain and Muscle Health

24min

Feeding Strategies for Canine Longevity

8min

Funding the Future of Aging Research

25min

Exploring Metformin and NAD Precursors: Benefits, Drawbacks, and Personalization

4min

10.

Skepticism Surrounding NAD Precursors and Lifespan Extension

2min

11.

Sirtuins and the Search for Longevity

23min

12.

Navigating the Landscape of Scientific Research

10min

13.

Reflections and Recommendations

7min

The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.

Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.

Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.

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[06:44] What is aging biology?

[08:43] How Matt pivoted from mathematics to biology.

[11:46] What is the Dog Aging Project?

[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.

[20:23] Rapamycin vs. sterile inflammation.

[23:07] Current thoughts about how the immune system changes as we age.

[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).

[42:20] Rapamycin and the Dog Aging Project.

[45:30] Rapamycin vs. neurodegeneration.

[48:21] What studies tell us about rapamycin’s potential to increase lifespan.

[51:30] Rapamycin alternatives considered for the Dog Aging Project.