#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

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Jul 27, 2022

Dr. Matt Kaeberlein, a leading researcher on aging from the University of Washington, dives into groundbreaking insights about longevity. He discusses the Dog Aging Project, revealing how canine studies can inform human health. The conversation highlights promising compounds like rapamycin and metformin and their role in extending healthspan. Kaeberlein also shares his personal experiences with aging research, dietary strategies for dogs, and the need for innovative funding in the pursuit of longevity. Tune in for a fascinating look at the future of aging!

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INSIGHT

Aging Biology Definition

Aging biology studies biological changes as organisms age, from molecular to behavioral levels.
These changes drive major causes of death and disability, as age is the greatest risk factor.

ANECDOTE

Kaeberlein's Introduction to Aging Biology

Matt Kaeberlein's interest in aging biology began during his graduate studies at MIT in 1998.
A talk by Lenny Guarente on a genetic approach to aging mechanisms sparked his interest.

ANECDOTE

Frozen Shoulder and Rapamycin

Matt Kaeberlein developed frozen shoulder, an age-related inflammatory condition, hindering his ability to throw a ball with his son.
After failed physical therapy, he self-treated with rapamycin, regaining most of his range of motion.

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The 4-Hour Body

An Uncommon Guide to Rapid Fat-Loss, Incredible Sex, and Becoming Superhuman

Tim Ferriss

In 'The 4-Hour Body,' Tim Ferriss shares the results of over a decade of self-experimentation and research, involving hundreds of elite athletes, dozens of MDs, and thousands of hours of personal testing. The book covers more than 50 topics, including how to lose weight quickly, gain muscle without steroids, sleep less and perform better, and improve sexual health. Ferriss emphasizes the importance of finding the smallest changes that produce the biggest results, making it accessible for readers to achieve significant improvements in their physical health and performance.

Wired to eat

Robb Wolf

In 'Wired to Eat', Robb Wolf explains how our genetics are working against us in the modern world of highly palatable foods. The book delves into the science behind appetite regulation, the impact of sleep, stress, and community on health, and introduces the concept of personalized nutrition. It includes a 30-Day Reset program to normalize appetite regulation and a 7-Day Carb Test to determine individual carbohydrate tolerance. The book also discusses ketogenic diets and intermittent fasting as potential tools for health improvement. Wolf emphasizes that each person's metabolism and nutritional needs are distinct, advocating for a personalized approach to dieting rather than one-size-fits-all solutions.

The paleo solution

The Original Human Diet

Robb Wolf

In 'The Paleo Solution,' Robb Wolf combines cutting-edge research from genetics, biochemistry, and anthropology to advocate for a return to the ancestral diet. The book proposes that modern humans should eat in a way that mimics the dietary habits of our Paleolithic ancestors, focusing on whole, unprocessed foods such as meat, fish, vegetables, fruits, nuts, and seeds, while avoiding grains, legumes, dairy products, and refined sugars. Wolf provides practical advice, meal plans, and real-life success stories to help readers transition to a Paleo lifestyle, which can lead to significant health improvements including better blood sugar control, lower cholesterol levels, reduced inflammation, and improved weight management.

The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.

Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.

Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.

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[06:44] What is aging biology?

[08:43] How Matt pivoted from mathematics to biology.

[11:46] What is the Dog Aging Project?

[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.

[20:23] Rapamycin vs. sterile inflammation.

[23:07] Current thoughts about how the immune system changes as we age.

[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).

[42:20] Rapamycin and the Dog Aging Project.

[45:30] Rapamycin vs. neurodegeneration.

[48:21] What studies tell us about rapamycin’s potential to increase lifespan.

[51:30] Rapamycin alternatives considered for the Dog Aging Project.