#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

The Tim Ferriss Show

notes

CHAPTER

Exploring Rapamycin and Immune Aging

This chapter presents a personal journey of dealing with a frozen shoulder and its emotional impacts, leading to a discovery of rapamycin's potential benefits. It explores the drug's effects on chronic inflammation, aging, and immune response, detailing its origins and applications beyond organ transplantation. Through discussions on senescent cells and intermittent treatment, the chapter highlights the importance of addressing healthspan over lifespan and the evolving understanding of aging biology.

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Transcript

Episode notes

The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.

Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.

Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.

Please enjoy!

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[06:44] What is aging biology?

[08:43] How Matt pivoted from mathematics to biology.

[11:46] What is the Dog Aging Project?

[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.

[20:23] Rapamycin vs. sterile inflammation.

[23:07] Current thoughts about how the immune system changes as we age.

[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).

[42:20] Rapamycin and the Dog Aging Project.

[45:30] Rapamycin vs. neurodegeneration.

[48:21] What studies tell us about rapamycin’s potential to increase lifespan.

[51:30] Rapamycin alternatives considered for the Dog Aging Project.