Reprogramming the Epigenome

2min Snip

00:00

Play full episode

Summary

Transcript

Episode notes

A lot of the developmental processes that allow for differentiation are largely mediated by epigenetic changes. So you can reprogram cells all the way back to this undifferentiated or de-differentiated state. The technology could have medical applications, such as using a skin biopsy in your own body - it would get around immune rejection challenges.

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.

Specifically, we discuss:

Intro (00:00)
Aging and disease (03:42)
Evolutionary conserved processes and human life span (17:41)
Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29)
Aging process and the burden of senescence cells (34:06)
Keys to a longer, healthier life (45:08)
Sleep and exercise (55:38)
Calorie restriction, longevity, and prolonged fasting (1:15:23)
Protein restriction and its implications (1:32:14)
Plant protein vs animal protein (1:43:31)
Natural occurring polyphenols and supplements related to longevity (1:53:06)
Rapamycin and rapamycin derivatives (2:13:53)
Anti-aging compounds (2:29:38)
Ethical implications of prolonging the life (2:51:08)
Outro (2:57:23)

To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.

Discover more insights and supporting resources in the full show notes.

Enjoy, friends.

Simon

Want to support the show?

The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.

Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

Watch the episodes on YouTube or listen on Apple/Spotify

Connect with me on Instagram, Twitter, and Facebook

Nourish your gut with my Plant-Based Ferments Guide

Download my complimentary two-week meal plan and high protein Plant Performance recipe book