The Proof with Simon Hill

Dr Robert Eckel, endocrinologist and former American Heart Association president, unpacks why obesity is more than BMI. He explains visceral versus subcutaneous fat and how adipose-driven insulin resistance develops. The conversation covers who benefits from weight loss, GLP-1 therapy questions, and practical ways to monitor metabolic risk.

Dr Natalie Crawford, board-certified OBGYN and reproductive endocrinologist who turned personal loss into patient-focused care. She discusses how sleep, inflammation, insulin resistance, and strength training shape egg and sperm health. Nutrition, key supplements, toxin avoidance, and realistic use of IVF or egg freezing are covered in practical, science-forward terms.

Dr. Karen Corbin, a registered dietitian and expert in nutrition and the gut microbiome, dives into how gut microbes can influence calorie absorption. She reveals that diet composition affects energy balance and discusses the fascinating concept of 'lost' calories due to fecal energy loss. Karen offers practical dietary tips to enhance microbiome health, emphasizes the importance of fiber, and clarifies the differences between probiotics and prebiotics. She also touches on future microbiome research and the potential of diet in personalizing metabolic health strategies.

Drew Harrisberg, a type 1 diabetes advocate and wellness communicator, joins to discuss life beyond strict health metrics. They explore the profound impact of gratitude and presence over optimization culture. Drew reflects on living with diabetes and the mental load of constant tracking, while emphasizing the joys of social movement and play. The conversation also delves into the evolution of their views on nutrition and exercise, touching on how resistance training can improve bone density and the importance of mindful protein intake for older adults.

Dr. Luc van Loon, a leading expert in exercise physiology at Maastricht University, shares groundbreaking insights into protein metabolism and muscle health. He debunks common protein myths, emphasizing the crucial role of amino acids and the effects of inactivity on muscle loss. The discussion covers the protein needs across different life stages, the impacts of diet types on muscle health, and how physical activity can combat anabolic resistance in aging. Luc also highlights practical advice for optimizing protein intake and digestion.

Join Dr. Thomas Dayspring, a clinical lipidologist specializing in cholesterol management, and Dr. Raymond Townsend, a cardiologist focused on cardiovascular imaging, as they dive into heart health strategies. They discuss optimal LDL and ApoB targets for preventing atherosclerosis, and the importance of early intervention. Dr. Iñigo San Millán shares insights on zone 2 training for metabolic health, while Dr. Dawn Mussallem emphasizes nutrition's role in cancer outcomes. Their conversations weave together cutting-edge research and practical advice for long-term wellness.

In this enlightening discussion, Dr. Matthew Nagra, a nutrition researcher, delves into the protein debate, weighing animal versus plant sources. Dr. Rupy Aujla, a medical doctor, emphasizes protein needs for longevity and gut health. Drew Harrisberg tackles misinformation surrounding wellness trends, specifically seed oils and beef tallow. Dr. Steven Novella explains why intelligent individuals can fall for pseudoscience, while Dr. David Katz clarifies what diet quality means. Insights into microbiome testing and its limitations are shared by Dr. Suzanne Devkota, rounding out a nuanced exploration of modern nutritional science.

Join Michelle Routhenstein, a preventive cardiology dietitian, as she debunks heart disease myths and emphasizes personalized nutrition over rigid rules. Discover how cholesterol, particularly ApoB, plays a significant role in cardiovascular health. Michelle explains the importance of balanced diets rich in soluble fiber and unsaturated fats, while also navigating the complexities of menopause and its effects on heart risks. Learn practical tips for reducing blood pressure and cholesterol through smart food choices, making heart health sustainable for the long term.

Dr. Suzanne Devkota is a microbiome researcher at Cedars-Sinai, specializing in gut health. In their discussion, she explains the importance of microbial diversity for gut resilience and the role of early life factors in microbiome development. Dr. Devkota clarifies the benefits and limitations of probiotics, prebiotics, and postbiotics. She shares fascinating insights on short-chain fatty acids, the connections between gut health and chronic diseases, and practical dietary tips to enhance microbiome health, emphasizing fiber-rich foods for optimal gut functionality.

Mark Manson, author of The Subtle Art of Not Giving a F*ck, dives deep into the nature of values and personal responsibility. He discusses the allure of 'shitty values' in youth and how recognizing them can transform lives. Mark argues for embracing failure and uncertainty, viewing negative emotions as vital to growth. He encourages taking ownership of choices, even post-heartbreak, and how being willing to be disliked fosters genuine trust. Finally, contemplating mortality helps prioritize what truly deserves our time and energy.