Is Activating mTOR a Detriment to Building Muscle?

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In order to build new muscle you have to turn up mTOR. And so there's this apparent paradox which is that the direction that increases lifespan and slows aging of turning down mTOR is opposite the direction of building muscle. So I think this idea that inhibiting mTOR in the context of increasing lifespan and slowing aging is irreconcilable with activating mTOR to build muscle really just reflects our current lack of understanding of the complexity of the system of the biology.

Episode #249. Have you ever wondered how long humans can healthily live for? Professor Matt Kaeberlain joins me in this episode to explain the biological processes of aging, explaining the significance of genetics vs lifestyle, protein restriction, polyphenols, and much more.

Specifically, we discuss:

Intro (00:00)
Aging and disease (03:42)
Evolutionary conserved processes and human life span (17:41)
Biological aging: Are epigenetic tests more accurate in telling how well you’re aging? (26:29)
Aging process and the burden of senescence cells (34:06)
Keys to a longer, healthier life (45:08)
Sleep and exercise (55:38)
Calorie restriction, longevity, and prolonged fasting (1:15:23)
Protein restriction and its implications (1:32:14)
Plant protein vs animal protein (1:43:31)
Natural occurring polyphenols and supplements related to longevity (1:53:06)
Rapamycin and rapamycin derivatives (2:13:53)
Anti-aging compounds (2:29:38)
Ethical implications of prolonging the life (2:51:08)
Outro (2:57:23)

To connect with Dr Matt Kaeberlein, you can find him on Twitter and LinkedIn. Head to his website, https://kaeberlein.org, to learn more about his work. If the Dog Aging Project interests you, you can visit the website or read this article in Nature. Keep up to date with Optispan here.

Discover more insights and supporting resources in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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