Cholesterol, metabolic health and heart disease | Dr Alan Flanagan and Danny Lennon

26 snips

Oct 27, 2022

Guest

Alan Flanagan

Guest

Danny Lennon

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INSIGHT

LDL Is The Primary Cholesterol Carrier To Watch

LDL and HDL are lipoproteins that transport cholesterol; LDL does forward transport and HDL does reverse transport.
LDL circulates longer and contacts arteries more, making it the primary atherogenic lipoprotein.

INSIGHT

ApoB Measures Particle Number, Not Just Cholesterol

ApoB counts the number of atherogenic lipoprotein particles because each particle carries one ApoB molecule.
ApoB often predicts cardiovascular risk better than LDL-C because it measures particle number, not cholesterol content.

INSIGHT

Particle Size And ApoB Drive Arterial Retention

Lipoprotein size determines arterial entry: particles <70–75 nm can penetrate the arterial intima and be retained.
Retention plus ApoB 'anchoring' to proteoglycans starts the inflammatory cascade that forms plaque.

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In Episode #231, I sit down with Dr Alan Flanagan and Danny Lennon to examine cholesterol, statins, the ketogenic diet, and longevity. Dr Alan Flanagan and Danny Lennon address whether cholesterol matters if you’re metabolically healthy, why our veins don’t get atherosclerosis, and why our body makes cholesterol if it’s “bad for us”. They also offer advice on dietary adjustments you can make regardless of your dietary pattern, claims by social media “health gurus”, and much more.

LDL cholesterol has been making waves on social media in recent years. With some diet camps making bold claims about its relevance and the apparently open-ended nature of the evidence, many folks are no doubt left unsure of how important cholesterol levels really are. In this episode, I’m joined by Danny Lennon and Dr Alan Flanagan to consider the role and importance of LDL cholesterol as we recap what the literature says.

Specifically, we discuss:

Intro (0:00)
Basics of Cardiovascular Health (4:29)
ApoB for Predicting Disease (12:18)
Heart Disease: Where things go wrong (23:23)
What Causes Artery Damage? (38:47)
Paul Saladino Claims (50:36)
Is low cholesterol a problem? (1:04:07)
Future of Gene Editing (1:27:12)
Veins vs Arteries (1:32:28)
Diet Claims (1:41:08)
Healthy Keto Diet (1:54:08)
MCT Oil (2:00:02)
Healthy Fats (2:03:28)
Final Thoughts (2:09:54)
Outro (2:19:05)

You can find Dr Alan Flanagan on Instagram, and learn more about Alinea Nutrition at https://www.alineanutrition.com/. Listen to his previous appearances on the show in Episode #159, Episode #225, and Episode #227.

To connect with Danny Lennon, head to his on Instagram and Twitter. Make sure to check out the Sigma Nutrition website and podcast. Danny previously appeared on The Proof in Episode #173.

Discover additional resources, supporting studies, and more insights in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, Msc, Bsc (Hons)

Creator of TheProof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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