The Proof with Simon Hill

Cholesterol, metabolic health and heart disease | Dr Alan Flanagan and Danny Lennon

Oct 27, 2022

02:27:39

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Highlights

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Episode notes

Is There a Justification for 10% Total Fat?

01:53

Is There a Difference Between Atherosclerosis and Life Expectancy?

03:02

Is There a Difference Between LDL and HDL?

04:19

Introduction

5min

Is There Evidence That Can Be Pointed to to Help Explain Cardiovascular Disease?

2min

What Is LDL Cholesterol?

3min

Is There a Difference Between LDL and HDL?

4min

How Do We Know How Many Lipoproteins Are Atherogenic Than HDL?

2min

Is There a Difference Between LDL and APOB?

2min

APOB Is the Strongest Indicator of LDL Cholesterol

4min

Lipoproteins Are Playing an Important Role in Atherogenicity

5min

Is Transitosis Normal?

6min

10.

Do Primates Develop Atherosclerosis?

5min

11.

What's the Difference Between Primary Prevention and Secondary Prevention?

2min

12.

Is Low APOB a Cause of Atherosclerosis?

3min

13.

Is LDL the Causal Pathway?

4min

14.

Is There a Risk of LDL Denialism?

5min

15.

Paul Saladino's Looked Deeper Than Other People's Consensus

2min

16.

Is LDL Cholesterol a Problem?

5min

17.

Is LDL a Poor Predictor of Cardiovascular Disease?

2min

18.

I'm a TIA, Right?

2min

19.

Is There a Better Evidence Base?

5min

20.

The LDL Receptor - The Critical Component in All of This

2min

21.

Do You Need Cholesterol?

3min

22.

Is LDL Carrying Cholesterol Good for Cell Membranes?

4min

23.

Is Low LDL Cholesterol a Risk Factor?

4min

24.

Is Lower Better for Cardiovascular Disease?

3min

25.

Atterosclerosis - Is There a Risk of Heart Disease?

4min

26.

Can We Just Allow Atherosclerosis to Progress for 10 Years?

5min

27.

Is There a Difference Between Atherosclerosis and Life Expectancy?

3min

28.

Is There a Process of Retention Within the Arterial System?

3min

29.

APOB, Is It a Cause of Atherosclerosis?

4min

30.

Diet and Cardiovascular Disease - It's Not Here for Diet

1min

31.

What Are the Main Principles of a Ketogenic Diet?

5min

32.

Is LDL a Cause of Coronary Disease?

4min

33.

LDL Evidence Isn't Valid, Is It?

2min

34.

Keto Dietary Modifications - What Are They Doing?

5min

35.

Low Carbohydrate Keto Diet

2min

36.

The Effects of Saturated Fats on Blood Cholesterol

5min

37.

Is There a Justification for 10% Total Fat?

2min

38.

Is Coconut Oil a Saturated Fat?

4min

39.

LDL Cholesterol - Is There a Hierarchy?

2min

40.

LP a Little Layer

3min

41.

Is There a Difference Between Seed Oils and LDL Cholesterol?

6min

In Episode #231, I sit down with Dr Alan Flanagan and Danny Lennon to examine cholesterol, statins, the ketogenic diet, and longevity. Dr Alan Flanagan and Danny Lennon address whether cholesterol matters if you’re metabolically healthy, why our veins don’t get atherosclerosis, and why our body makes cholesterol if it’s “bad for us”. They also offer advice on dietary adjustments you can make regardless of your dietary pattern, claims by social media “health gurus”, and much more.

LDL cholesterol has been making waves on social media in recent years. With some diet camps making bold claims about its relevance and the apparently open-ended nature of the evidence, many folks are no doubt left unsure of how important cholesterol levels really are. In this episode, I’m joined by Danny Lennon and Dr Alan Flanagan to consider the role and importance of LDL cholesterol as we recap what the literature says.

Specifically, we discuss:

Intro (0:00)
Basics of Cardiovascular Health (4:29)
ApoB for Predicting Disease (12:18)
Heart Disease: Where things go wrong (23:23)
What Causes Artery Damage? (38:47)
Paul Saladino Claims (50:36)
Is low cholesterol a problem? (1:04:07)
Future of Gene Editing (1:27:12)
Veins vs Arteries (1:32:28)
Diet Claims (1:41:08)
Healthy Keto Diet (1:54:08)
MCT Oil (2:00:02)
Healthy Fats (2:03:28)
Final Thoughts (2:09:54)
Outro (2:19:05)

You can find Dr Alan Flanagan on Instagram, and learn more about Alinea Nutrition at https://www.alineanutrition.com/. Listen to his previous appearances on the show in Episode #159, Episode #225, and Episode #227.

To connect with Danny Lennon, head to his on Instagram and Twitter. Make sure to check out the Sigma Nutrition website and podcast. Danny previously appeared on The Proof in Episode #173.

Discover additional resources, supporting studies, and more insights in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, Msc, Bsc (Hons)

Creator of TheProof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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