Freely Filtered, a NephJC Podcast

Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?

Feb 27, 2022

01:17:58

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Highlights

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Episode notes

Minimally Change Disease

01:43

How to Purify a Nephron

01:59

Confocal Microscopy - Super, Super?

01:26

Introduction

2min

Neff J.C. - Minimal Change Disease

2min

IgG Staining in Primary Nephrology

2min

I F Is Negative in Minimally Change Disease?

1min

Nephropathology - Is IF the Dark Art of Nephro Pathology?

2min

IgG Dusting in the Neptune Cohort

2min

FSGS and MCD - Is There a Circulating Factor?

3min

Nephrotic Syndrome - Is There a Pathologic Variant in Neptune?

2min

Nephrotic Antibodies

2min

10.

Immunoprecipitation for Nephron Staining

2min

11.

The White Whale in Nephrology?

2min

12.

How to Purify a Nephron

2min

13.

Confocal Microscopy - Super, Super?

1min

14.

Nephrology - Is That What You Were Thinking About?

2min

15.

Using Confocal Microscopy to Detect Antigens

2min

16.

Anti-Nephron Antibody - Is That Right?

2min

17.

Nephron Auto Antibody Detection - A Fishing Expedition?

2min

18.

Anti-Nephron Antibody Levels - Is That Normal?

2min

19.

What's Happening to Anti-Nephrin Antibody?

2min

20.

Nephrin Connection Breaks Apart

2min

21.

Antinephrine Antibody

2min

22.

Do You Know Who Came Up With the Sentence Did Not Reach Conventional Levels of Statistics?

2min

23.

Is There an Anti-Nephrin Antibody?

2min

24.

Anti-Nephron Antibodies in Minimal Change Disease

2min

25.

Nephron Specific Co-Location

1min

26.

Using a Podocyte Marker to Stain Nephron

2min

27.

Nephrin Autoantibodies in the Serum of a Kidney Transplant Patient

2min

28.

Anti-Nephrin Antibodies in Kidney Transplants

2min

29.

FSGS

1min

30.

FSGS

2min

31.

Endothelial Inflammation - Is There a Circulating Factor?

2min

32.

Is April 1 a Risk Allele for FSGS?

2min

33.

Anti-Nephrin

2min

34.

Anti-Nephronid Antibody Levels

2min

35.

Nephrotic Syndrome

2min

36.

Nephrotic Syndrome - Is This a Good Biomarker for Kidney Disease?

2min

37.

Minimally Change Disease

2min

38.

Is the Bar Higher Than It Is With Other Studies?

2min

39.

The Journal of American Society of Nephrology

2min

40.

No Nephrology Social Media Collective Internship

3min

41.

Pseudo Hyper Aldosteroneisms - Is There a Way to Treat Them?

2min

42.

What Do You Got First?

2min

43.

How to Read Excellent Fast Range You Got a Tubular Secretion for Your Family

2min

The Filtrate:

Joel Topf

Jennie Lin

Joshua Waitzman

Nayan Arora

Sophia Ambruso

Special Guest:

Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical School

Editor:

Nayan Aurora

Show Notes:

Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy specimens is negative, and no immune complexes are evident.

Minimal change disease and idiopathic FSGS: manifestations of the same disease

New Views of the Glomerulus: Advanced Microscopy for Advanced Diagnosis

Imaging of the Porous Ultrastructure of the Glomerular Epithelial Filtration Slit

Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice

Fishing Expedition

Koch's postulates

Measles in the Nephrotic Syndrome

NEPTUNE: NEPhrotic syndrome sTUdy NEtwork

Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation

Most of these patients have a homozygous truncating mutation (Fin-major mutation) in the nephrin gene (NPHS1), leading to total absence of the major podocyte protein, nephrin. After RTx, these patients develop anti-nephrin antibodies resulting in nephrotic range proteinuria.

Nephrotic syndrome relapse in a boy with COVID-19

Minimal Change Disease After First Dose of Pfizer-BioNTech COVID-19 Vaccine: A Case Report and Review of Minimal Change Disease Related to COVID-19 Vaccine

Dr. Laurence Beck and the discovery of Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy as published in the NEJM.

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