Is There an Anti-Nephrin Antibody?

The Filtrate:

Joel Topf

Jennie Lin

Joshua Waitzman

Nayan Arora

Sophia Ambruso

Special Guest:

Astrid Weins (@AstridWeins) renal pathologist at the Brigham and Woman’s Hospital and Harvard Medical School

Editor:

Nayan Aurora

Show Notes:

Summary of minimal change disease according to the orthodoxy: Light microscopy of renal biopsy specimens from patients with MCD shows minimal to no change; however, electron microscopy reveals the effacement of podocyte foot processes. To add to the conundrum, immunofluorescent staining of biopsy specimens is negative, and no immune complexes are evident.

Minimal change disease and idiopathic FSGS: manifestations of the same disease

New Views of the Glomerulus: Advanced Microscopy for Advanced Diagnosis

Imaging of the Porous Ultrastructure of the Glomerular Epithelial Filtration Slit

Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice

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Koch's postulates

Measles in the Nephrotic Syndrome

NEPTUNE: NEPhrotic syndrome sTUdy NEtwork

Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation

Most of these patients have a homozygous truncating mutation (Fin-major mutation) in the nephrin gene (NPHS1), leading to total absence of the major podocyte protein, nephrin. After RTx, these patients develop anti-nephrin antibodies resulting in nephrotic range proteinuria.

Nephrotic syndrome relapse in a boy with COVID-19

Minimal Change Disease After First Dose of Pfizer-BioNTech COVID-19 Vaccine: A Case Report and Review of Minimal Change Disease Related to COVID-19 Vaccine

Dr. Laurence Beck and the discovery of Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy as published in the NEJM.

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