Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?
Freely Filtered, a NephJC Podcast
Anti-Nephron Antibody - Is That Right?
You really need an antibody that binds directly to a slit diaphragm component and just actively disrupts the connection between two photosites. There aren't that many proteins that are candidates, you know, at the slit diagram that have an extracellular component. And it's somewhere else in the photosite or on the surface,. which is what you see at as this kind of dusting, staining these little vesicles or filled dots. That's probably nephron that's already clustered by the antibody. But there's presumably other antibodies, right? I mean, just like membranous.
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