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The Stronger By Science Podcast
Aspartame: The Surprisingly Interesting Science and History
Jul 19, 2023
05:43:57
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Quick takeaways
- Aspartame's approval history raised skepticism due to industry ties and flawed studies.
- Aspartame's classification as possibly carcinogenic signifies a potential hazard, not confirmed risk.
- Media coverage of scientific studies like the Ramazini study can lead to misinformation.
- IARC assessments focus on the potential of substances to cause cancer, not the probability.
- The historical context of artificial sweeteners contributes to public distrust and safety concerns.
- Clear communication of scientific findings is crucial to prevent misinterpretation and build public trust.
Deep dives
Overview of Aspartame Approval Process
The approval process for Aspartame started with the FDA in 1974, where concerns were raised about the safety studies submitted by the company. A public inquiry by the FDA's task force recommended against approval due to poor quality studies. A grand jury investigation was delayed and eventually expired. Conflicting information about brain tumors led to FDA investigations and external reviews sponsored by the company, raising suspicion due to ties between regulators and the company executives.
Controversy Around Aspartame Approval
Amidst conflicting reports on brain tumors and regulatory investigations, approvals for Aspartame were clouded by skepticism. Concerns arose over potential associations with brain tumors, leading to a public inquiry and external reviews funded by the company's executives. Regulatory decisions were criticized for ties between FDA regulators and the company executives, casting doubt on the review process.
Significance of Historical Context
The historical context of previous artificial sweetener approvals, industry ties, and regulatory decisions brought skepticism to Aspartame approvals. Ramifications of corporate influence, flawed safety studies, and regulatory actions significantly impacted public perception and trust in the safety of Aspartame, adding complex layers of controversy and doubt.
Ramazini Study Criticized for Methodological Flaws
The Ramazini study on aspartame's effects on cancer rates has come under scrutiny for methodological flaws. Not adjusting for litter effects and misidentifying tumors were major concerns raised by independent agencies and critics. Some critics argued that the research did not meet high scientific standards, questioning the reliability of the results.
Journalistic Challenges in Reporting Scientific Studies
The media response to the Ramazini study highlights the challenges journalists face in reporting scientific studies. The reliance on sources like Dr. Ralph Walton, whose methodology and analysis have been criticized, underscores the difficulty in discerning credible information, leading to potential misinformation in public discourse.
Credibility Concerns Surrounding Research Sources
The New York Times article featured fanfare about the credibility of the Ramazini Cancer Lab, despite criticisms of its lead researcher's methods. Emphasizing the lab's pioneering history in chemical research, the article highlighted a need for critical evaluation of research sources to ensure transparency and accuracy in reporting.
Biological Plausibility of Aspartame's Carcinogenicity
Aspartame breakdown products are normal amino acids and methanol found in typical human diets. Even at maximum consumption, aspartame provides less phenylalanine, aspartate, and methanol than normal dietary intake. Methanol levels from aspartame are minimal compared to natural sources like fruit juices.
Understanding IARC's Classification System
IARC assesses hazard, not risk, by evaluating the potential of a substance to cause cancer. A Group 2B classification like aspartame being possibly carcinogenic to humans signifies a hazard presence, not a definite risk. IARC's methodology focuses on the strength of evidence showing a substance can cause cancer, not the probability it will cause cancer.
Implications of IARC's Classification
Aspartame's placement in Group 2B as a possible carcinogen highlights scientific indicators of a potential hazard, not a confirmed risk. The classification emphasizes the need for ongoing research and monitoring. The focus is on assessing the strength of evidence for carcinogenicity rather than absolute risk levels.
Overview of IARC Classifications
IARC classifications are discussed, highlighting the distinction between hazard and risk assessments. The importance of understanding the meaning behind IARC classifications is emphasized.
Impact of Previous Media Coverage
Past sensationalized media coverage regarding food safety scares, like the red meat classification, is mentioned to highlight the need for critical thinking and better understanding of scientific reports.
Critique of Misleading Reporting
Certain articles, such as those questioning the FDA approval process for aspartame and pointing to industry-funded studies, are critiqued for potentially misleading readers by not adequately considering the full context and recent research regarding the safety of aspartame.
Understanding the Cultural Anxiety Around Artificial Sweeteners
The history of artificial sweeteners like aspartame reveals a deep-seated cultural anxiety, rooted in decades of misinformation. From the FDA approval process to labels indicating cancer risks, the public perception of artificial sweeteners as unsafe has been pervasive. This historical context sheds light on why many people harbor distrust towards artificial sweeteners, perpetuating a narrative that has endured over time.
Challenges in Scientific Communication and Oversight
The podcast highlights the complexities of evaluating and communicating scientific findings to the public. It points out the challenges that arise when organizations like the World Health Organization fail to provide adequate context and clarification on research outcomes. While individual scientists may struggle with public dissemination of their work, larger entities such as WHO bear the responsibility to ensure accurate reporting and prevent misinterpretation of scientific data.
80.
Aspartame Is Only the Latest Battleground for Multinational Companies to Push Back Against New Studies
2min
Greg and Lyndsey dive into the history, conspiracies, science, and media coverage of aspartame to present a thorough overview of the recent WHO reports linking aspartame and cancer risk.
Is this one of the longest "podcast episodes" ever? Probably. But it's packed with fascinating history, relevant research breakdowns and media criticism, and takeaways for interpreting and navigating our society's abundance of health warnings.
TIME STAMPS
- History of artificial sweeteners preceding aspartame (9:43)
- The very sketchy approval process for aspartame and subsequent media coverage (1:02:35)
- Breaking down the World Health Organization's decision to classify aspartame as "possibly carcinogenic" (3:17:50)
- The fallout from the WHO's classification (4:24:27)
- Closing thoughts (5:22:04)
MORE FROM THE SBS TEAM
- Join the Research Spotlight newsletter: Get a two-minute breakdown of one recent study every Wednesday. Our newsletter is the easiest way to stay up to date with the latest exercise and nutrition science.
- Join the SBS Facebook group and Subreddit.
- Try MacroFactor for free: Use code SBS to get a 14-day free trial of our nutrition app MacroFactor. MacroFactor has the fastest food logger on the market and its smart nutrition coach adapts to your metabolism to keep you on track with your goals. Download it today on the App Store or Google Play.
- Work with a Stronger By Science coach: Get personalized training and nutrition plans and ongoing support from one of our expert coaches.
RECOMMENDED PRODUCTS
- MASS Research Review: Subscribe to the MASS Research Review to get concise and applicable breakdowns of the latest strength, physique, and nutrition research – delivered monthly.
- BulkSupplements: Next time you stock up on supplements, be sure to use the promo code “SBSPOD” (all caps) to get 5% off your entire order.
SOURCES AND LINKS
Intro
- Greg's recommendation: Factor meals
- Lyndsey's recommendations: Sturdy Girl Club stand-up series and Casey Johnston’s newsletter “She’s a Beast”
WHO Reports
- WHO: Aspartame hazard and risk assessment results released
- The Lancet summary: Carcinogenicity of aspartame, methyleugenol, and isoeugenol
Full source list
- We had too many links to include here (lol), so please go to the page on Stronger By Science for a fully guided tour of our derangement: https://www.strongerbyscience.com/podcast-episode-116/
MORE FROM THE SBS TEAM
- Work with a Stronger By Science coach: Get personalized training and nutrition plans and ongoing support from one of our expert coaches.
- Join the Research Spotlight newsletter: Our newsletter is the easiest way to stay up to date with the latest exercise and nutrition science.
- Join the SBS Facebook group and Subreddit.
RECOMMENDED PRODUCTS
- Try MacroFactor for free: Use code SBS to get a 14-day free trial of our nutrition app MacroFactor. MacroFactor has the fastest food logger on the market and its smart nutrition coach adapts to your metabolism to keep you on track with your goals. Download it today on the App Store or Google Play.
- BulkSupplements: Next time you stock up on supplements, be sure to use the promo code “SBSPOD” (all caps) to get 5% off your entire order.
- MASS Research Review: Subscribe to the MASS Research Review to get concise and applicable breakdowns of the latest strength, physique, and nutrition research – delivered monthly.
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