Critical Care Reviews Podcast

FIRST-ABC (step up) Trial Result Presentation

Jul 20, 2022

01:24:56

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Episode notes

Introduction

2min

The Role of Non-Invasive Respiratory Support in Pediatric Critical Care

2min

The Role of High-Flow Nasal Cannula in Primary Respiratory Support

2min

The Importance of Pilot Trials

2min

The Step Down RCT and the Comparison of the Results

4min

How to Deliver High Flow and Nasal Cannula and CPAP Interventions

2min

The Effect of High-Flow Nasal Cannula on Patient Comfort

3min

The Role of Primary Analysis in Non-Inferiority in Respiratory Sports

2min

The Trial of Noninvasive Respiratory Support in Children

6min

10.

The Effects of Comfort Scores on Patients With ARDS

6min

11.

The Effect of Randomization on Mortality at PQ Discharge

5min

12.

The Non-Inferiority of High Flow in the Step Up Trial

4min

13.

The Importance of Randomization in Pediatric Trials

6min

14.

The Differences Between ITT and Pro Protocol Analysis

3min

15.

The Benefits of High Frequency Oscillation in Pediatric Critical Illness

2min

16.

Non-Inferiority Trials

5min

17.

The Effects of High Flow on Long Term Mortality

2min

18.

The Importance of Patient Selection for Respiratory Support

2min

19.

The Effects of CPAP on Non-Inferiority

2min

20.

The Differential Practices Around Weaning for High Flow and CPAP

2min

21.

The Influence of Bias on the Reporting of Outcomes

2min

22.

The Limits of Crossover in a Non-Fairy Ority Trial

2min

23.

The Role of Oxygen in Hypoxic Patients

2min

24.

The Effects of Oxygenation on Mortality at Day 180

2min

25.

The Importance of Indication Creep in Respiratory Support

2min

26.

The Importance of Design in Non-Inferiority Trials

2min

27.

How to Interpret Clinical Trials

2min

28.

How Much Latitude Should We Give High Flow Nasal Cannula Therapy?

2min

29.

The Effects of High-Flow on Respiratory Support in ICUs

2min

30.

The Importance of Oxygen in Critical Care

2min

31.

The Role of High Flow in Pediatrics

2min

Drs Padmanabhan Ramnarayan and Paul Mouncey (both London) present the results of the FIRST-ABC trial, comparing high-flow nasal cannulae therapy with CPAP in acute ill children with respiratory failure, at the Critical Care Reviews Meeting 2022. Dr Srinivas Murthy (Vancouver) delivers an editorial, which is followed by a panel discussion including Profs Kathryn Maitland (Kalifi), John Marshall (Toronto) and Marion Campbell (Aberdeen). The session is chaired by Prof Howard Bauchner.