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- IgA-virus immune complexes potentiate netosis in neutrophils, leading to higher levels of netosis compared to antibody alone or virus alone.
- Monoclonal antibodies that bind the stalk region of the influenza virus hemagglutinin can induce netosis in neutrophils, suggesting potential protection against influenza.
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IGA-mediated netosis is stimulated by influenza virus
When monomeric IGA antibodies are complexed with influenza virus, it induces higher levels of netosis in neutrophils compared to antibody alone or virus alone. This stimulation is specific to IGA, as IGG does not induce netosis in the presence of the virus. The stimulation is more efficient when the ratio of IGA to virus is two to one. Pictures show the formation of nets, consisting of DNA strands and neutrophil elastase, in the presence of IGA and influenza virus.
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