Delve into the fascinating world of basophils and their surprising role in regulating lung inflammation and asthma. Learn about the complexities of lupus as autoreactive T-cells target neoself-antigens, emphasizing the condition's tricky diagnosis. Discover the crucial functions of MHC molecules in immune responses and the implications of invariant chain research in understanding autoimmunity. The hosts also explore the relationship between stress and immune response, revealing how it can trigger autoimmune diseases like lupus.

Discover the fascinating world of olfactory mucosal macrophages and their role in fighting infections and maintaining neuronal health. Learn about the surprising lack of long-lived SARS-CoV-2-specific plasma cells post-mRNA vaccination. Delve into the connection between macrophages, sensory loss, and the lingering effects of COVID-19 on taste and smell. Understand the dynamics of immune responses to various vaccines, revealing the complexities of how our bodies defend against viral threats.

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Immune memory diversity in human upper airway (Nature) How Plasmodium infection promotes B cell cancers (Cell) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Petter Brodin, an immunologist from the Karolinska Institute, dives into the fascinating world of immune responses in trans-men undergoing testosterone therapy. He discusses how testosterone levels significantly affect immune cell populations and the intricate relationship between hormones and immunity. Brodin emphasizes the importance of careful monitoring of gender-affirming treatments and explores the complexities of studying human immunology compared to traditional models. His insights shed light on the evolutionary aspects of immune regulation, creating a rich dialogue around gender dynamics and health.

Dive into the fascinating world of autoimmune diseases as Mark Shlomchik shares his journey from medicine to impactful immunology research. Discover the pivotal role of B-cells and the breakthroughs in autoantibody understanding. The conversation uncovers the significance of mentorship and the art of scientific inquiry. Learn about innovative treatments like CAR T-cell therapy and the challenges faced in research. Lastly, enjoy a glimpse into personal passions, including music and baking, emphasizing the creativity in science.

Heather Caslin, an Immunologist at the University of Houston, takes listeners through her inspiring journey from sports to science. She shares fascinating insights into how diet and exercise influence innate immune cells, the complex relationship between exercise physiology and stress, and the challenges of launching a new research lab. Highlighting the significance of science communication, she emphasizes the need for engaging education in immunology while also discussing potential future applications of her groundbreaking research.

Discover the fascinating world of microglia, the brain's immune superheroes, as they shape brain development and fight neurodegenerative diseases. Learn how mast cells ingeniously trap neutrophils, boosting their functionality and insights into allergic responses. The hosts dive into the dynamics of interferon in brain immunity, revealing its critical role in both health and inflammation. Explore how these immune interactions can reshape our understanding of diseases and promote innovative research in immunology.

David Martinez, a scientist at the Yale Institute for Global Health, explores the world of viral pathogens and his journey in science, influenced by his early experiences in El Salvador. He shares insights on the critical role of mentorship in studying emerging infectious diseases, including HIV and coronaviruses. The discussion covers vaccine innovations and the importance of understanding genetic variations in viruses, all while highlighting the need for persistence in research. Martinez inspires future biomedical scientists to enjoy the journey despite challenges.

Robert Binder, a Professor at the University of Pittsburgh, discusses his fascinating journey from Ghana to the U.S. and his research on heat shock proteins, vital players in cancer immunosurveillance. He emphasizes the importance of mentoring young scientists and inspiring them through engaging, hands-on experiments. The conversation dives into how heat shock proteins trigger immune responses against cancer cells, their critical roles in developing cancer vaccines, and the complexities of immune responses. It's a riveting look into the intersection of mentorship and cutting-edge research!

Rafael Polidoro, a researcher at Indiana University School of Medicine, dives into the fascinating world of the gut microbiome and its connection to immune responses during infections. He shares his unique journey from music to malaria research and discusses how specific bacteria can enhance vaccine efficacy. The conversation also touches on the importance of persistence in science, the challenges faced by underrepresented communities, and the vital role of supportive networks in navigating the scientific landscape.