Immune Immune 98: T cells on the brain
Nov 25, 2025
Discover how cross-reactive antibodies may offer protection against avian influenza. Learn about gut-derived T cells in the brain that influence eating behaviors. Delve into their roles in steady-state regions like the subfornical organ and how diet changes impact these T cells. The discussion also highlights the intricate connection between the gut microbiome and brain immunity, revealing the complexities of T cell trafficking and their potential effects on behavior. Packed with cutting-edge research and intriguing insights!
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Antibodies Mimic Sialic Acid To Block NA
- Some anti-NA antibodies insert a CDRH3 loop into the NA active site and mimic sialic acid.
- Different antibodies use related motifs (DR/RD) or backbone interactions to achieve this receptor mimicry.
Glycan Shielding Alters Antibody Binding
- Viral glycosylation can block antibody binding without changing epitope residues.
- A glycan at NA residue 245 prevents HB420 binding to recent H3N2 strains.
Somatic Hypermutation Drives Cross-Reactivity
- Reverting HB420 to germline retained N2 binding but lost H5N1 N1 binding.
- Heavy-chain somatic hypermutations were critical to evolve N1 cross-reactivity.