The Hygiene Hypothesis of Autoimmune Disorders

Alexander writes Dear Immune professors. If the hygiene hypothesis of autoimmune disorders turns out to be true, wouldn't that be bad news for long term human habitation in space? The microbiome of a Mars colony is like to be much smaller and less varied than on earth. Wouldn't we expect future generations born on Mars or other space habitats to have massive autoimmune issues because of that,. assuming the high policies, the hygiene hypothesis is accurate. Your insights would be greatly appreciated since yearly Alexander.