Critical Care Reviews Podcast

PILOT Trial Result Livestream

Oct 25, 2022

01:39:54

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Episode notes

Introduction

2min

The Pilot Trial of Mechanical Ventilation for Critically Ill Adults

4min

The Role of Early Intervention in Critical Illness

3min

The Pilot Trial of COVID-19 Hypoxemia

2min

The Role of Cluster Level Allocation in Ozone Targets in Clinical Care

3min

The Effects of Mechanical Ventilation on SPU2

3min

The Pilot Trial of Invasive Mechanical Ventilation for Critical Care Patients

3min

The Effects of Cluster Level Group Assignment on SPO2 Values

3min

The Primary Outcome of Ventilator 3 Days

2min

10.

The Pilot Trial in Mechanically Ventilated Critically Ill Adults

4min

11.

The Importance of Oxygen Therapy in Critical Illness

2min

12.

The Three Arm Cluster Multiple Crossover Trial

3min

13.

The Importance of Cluster Crossover Trials

2min

14.

The Advantages of Having Only One Center Participating in a Crossover Trial

2min

15.

The Trade-Off Between Cluster Crossover and Randomized Trials

4min

16.

The Strengths of the Chronic Mechanical Ventilation Trial

3min

17.

The Problem With Ventilator Three Days

1min

18.

The Precision of Treatment Estimates in Relation to Ventilator Three Days

2min

19.

The Effects of Oxygen Therapy on Primary Outcomes

1min

20.

Liberal Oxygen Therapy Reduces Mortality by 1.6 Percentage Points

3min

21.

The Megaox Trial: A Pilot Trial at an Oxygen Therapy

3min

22.

The Limits of Generalizability in a Target Trial

5min

23.

The Reluctance to Aim for a Lower SBO2

2min

24.

The Effects of Mechanical Ventilation on Oxygen Levels

6min

25.

How to Target Oxygenation in COPD Patients

3min

26.

The Effects of Modification on COPD Patients

3min

27.

The Role of SPO2 in Hyperoxia

3min

28.

The Effects of Local to on SPO2 Values

3min

29.

The Importance of Early Intervention for ARDS

4min

30.

The Importance of Washout Periods in the Design of Crossovers

5min

31.

The Effects of Gas Exchange Impairment on SPO2 in Hyperxemia Patients

2min

32.

The Role of FIO2 in Oxygen Therapy in the ICU

4min

33.

The Importance of Targeting Higher Oxygenation in a Post-Type Trial

2min

34.

The Importance of Low Oxygen in Critical Care

3min

Matthew Semler presents the results of the PILOT trial, comparing low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Paul Young delivers an editorial and Chris Nutt asks questions from the viewers. The expert panel discussion includes Victoria Cornelius, Angelique de Man, Bodil Steen Rasmussen and Gilles Capellier. The paper was simultaneously published in the New England Journal of Medicine.