The Importance of Low Oxygen in Critical Care

I don't think there's a strong biological rationale for doing that myself but you know like I guess if we get to the point after the megarox trial where low looks like it's best then it might be reasonable to say well like if low's best is a bit lower even better. Most of the trials now particularly the more recent high quality trial high quality trials have a point estimate in favor of more liberal oxygen. So why it would be a good idea to target abnormally low oxygen is not not all that clear to me thanks very much Paul Mash will leave the final word with you.