The Importance of Washout Periods in the Design of Crossovers

Matt Boddle: I think there's two things that really stuck out to me. The first is about the design of the washout periods and whether or not that would have been better straddling two periods, would that have helped increase the separation in your group? And the second sort of point I wanted to make, because I know everybody's, you know, there is, this is clearly made good separation between the groups, that you achieve that more than the other trials. But if I go back to your research question, it wasn't as much as you had intended to, youknow, you really haven't targeted that lower level. So those are both great questions. Thanks