Mastering Nutrition

Dmitry Kats, PhD: From Niatonin to Niacur

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Jan 4, 2022
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INSIGHT

Niacin Beyond NAD+: A Broader Mechanism

  • Dmitry Kats argues niacin's antiviral and anti-inflammatory roles extend beyond NAD+ synthesis to receptor-mediated cellular effects.
  • He links chronic niacin insufficiency to inflammation, butyrate depletion, and impaired immune maintenance.
INSIGHT

Butyrate As An Immune Modulator

  • Butyrate, produced by gut microbes, modulates systemic immunity and maintains intestinal homeostasis.
  • Loss of butyrate abundance disrupts T-cell balance and predisposes to chronic inflammation and disease.
INSIGHT

Rethinking The Niacin Flush

  • Kats reframes the niacin 'flush' not simply as a nuisance but as a sign niacin failed to reach its intended gut receptor pathway.
  • He now treats flushing as undesirable 'spillover' acidity rather than beneficial exfoliation.
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