Mastering Nutrition
Chris Masterjohn, PhD
Welcome to the Mastering Nutrition podcast.
Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks.
He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.
Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks.
He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.
Episodes
Mentioned books
7 snips
Dec 15, 2025 • 7min
Depression Starts In Your Mitochondria
Explore how mitochondrial dysfunction ties into depression. Discover how altitude affects oxygen and ATP production, influencing mental health. Learn the role of methylation in emotional flexibility and how fighting negative thoughts drains energy. Understand the metabolic pathways involving SAMe and the need for healthy mitochondria. Finally, compare the pros and cons of SAMe supplementation versus restoring mitochondrial function for better mood and longevity.
Dec 9, 2025 • 3min
Aging is best explained by declining mitochondrial function over time.
The discussion centers on the link between aging and declining mitochondrial function. Mitochondria are crucial for energy production and cellular repair, and their decline initiates a vicious cycle of deterioration. Chris Masterjohn highlights that factors like genetics, environment, and lifestyle influence how much mitochondrial function we lose. With an estimated average of 1% loss per year, improving mitochondrial health at any age can slow this decline significantly. Aging isn't just natural—it's a complex interplay of various factors!
6 snips
Dec 7, 2025 • 2min
The Medical Myth That Nutritional Deficiencies Are A Thing of the Past
The discussion kicks off with iodine testing and thyroid hormone insights. A compelling argument surfaces, challenging the belief that nutritional deficiencies are a thing of the past. It highlights how initiatives to reduce salt intake have unintentionally stripped away vital iodine sources. Finally, a cardiologist reveals a surprising resurgence of goiter cases, reminding listeners that iodine deficiency is making a comeback.
4 snips
Dec 7, 2025 • 2min
Why Doctors Think They Can Ignore the Studies Suggesting Seed Oils Cause Heart Disease
Explore how medicine relies on simplified models during diagnosis, with Chris Masterjohn emphasizing that these are merely hypotheses. Discover why many clinicians tend to overlook the intricate details, like the impact of seed oils on LDL, as they can be unrelated to treatment choices. The conversation dives deep into the disconnect between medical theory and practical application, raising eyebrows on the implications for heart disease.
Dec 5, 2025 • 5min
The Problem With Seed Oils and Why They Are So Controversial
Explore the debate surrounding seed oils and their impact on health. Discover how these oils can increase tissue vulnerability and contribute to long-term damage. Aging plays a role in worsening this effect, revealing more harm as mitochondrial repair declines. Learn about studies that show initial benefits but subsequent health risks, highlighting the need for longer-term research. Chris Masterjohn argues that short trials miss these delayed effects, suggesting a reevaluation of diet-based health conclusions.
82 snips
Dec 4, 2025 • 1h 43min
Mitochondria: Why They Control Everything in Human Health
Mitochondria are the powerhouses of our cells, converting food into energy and influencing our overall health. Their dysfunction is linked to aging and various health issues, including depression and acne. The podcast emphasizes the importance of tailoring health strategies to individual mitochondrial needs. It critiques SSRIs and statins, pointing out their potential mitochondrial drawbacks. Additionally, the conversation covers innovative solutions like Mitome testing for personalized health insights and the role of sunlight and exercise in supporting mitochondrial function.
8 snips
Nov 23, 2025 • 1h 29min
SSRI Withdrawal Is Mitochondrial Dysfunction
Dive into the complexities of SSRI withdrawal and its surprising link to mitochondrial dysfunction. Discover the range of withdrawal symptoms that affect many, from anxiety to bizarre sensory experiences. Learn why SSRIs may be overprescribed and how serotonin functions beyond mood regulation. Gain insights on practical tapering strategies and the importance of mitochondrial support for a safer recovery. This discussion reveals the intricate balance between antidepressant use and overall body function.
Sep 6, 2024 • 1h 35min
How Lactate Alkalinizes Your Muscles
Andy Galpin, an exercise science expert, and George Brooks, a leading researcher on lactate, dive into the surprising truth about lactate and muscle alkalinization. They debunk the myth that lactic acid causes muscle soreness and fatigue, revealing that lactate actually helps alkalinize muscles. The conversation covers the biochemical processes of lactate production, its role in preventing exercise-induced acidosis, and insights into muscle fatigue mechanisms. They also discuss the limited benefits of lactate supplements and effective strategies to enhance performance.
Jul 31, 2024 • 1h 30min
D-Lactate: Groundbreaking Research No One Is Talking About
D-lactate is not just a byproduct of bacteria; human enzymes produce it too! This groundbreaking research challenges misconceptions and highlights its role in energy metabolism and gluconeogenesis. The term “D-lactate shuttle” is introduced, showcasing its significance alongside classic shuttles in balancing cellular functions. Explore its implications in neurological conditions like Parkinson's and autism, questioning previous assumptions on its minimal presence and emphasizing its importance in maintaining metabolic health.
Jul 12, 2024 • 2min
Handling Creatine Side Effects
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here: https://chrismasterjohnphd.substack.com/p/handling-creatine-side-effects Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
