
Mastering Nutrition
Welcome to the Mastering Nutrition podcast.
Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks.
He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.
Latest episodes

Sep 6, 2024 • 1h 35min
How Lactate Alkalinizes Your Muscles
Andy Galpin, an exercise science expert, and George Brooks, a leading researcher on lactate, dive into the surprising truth about lactate and muscle alkalinization. They debunk the myth that lactic acid causes muscle soreness and fatigue, revealing that lactate actually helps alkalinize muscles. The conversation covers the biochemical processes of lactate production, its role in preventing exercise-induced acidosis, and insights into muscle fatigue mechanisms. They also discuss the limited benefits of lactate supplements and effective strategies to enhance performance.

Jul 31, 2024 • 1h 30min
D-Lactate: Groundbreaking Research No One Is Talking About
D-lactate is not just a byproduct of bacteria; human enzymes produce it too! This groundbreaking research challenges misconceptions and highlights its role in energy metabolism and gluconeogenesis. The term “D-lactate shuttle” is introduced, showcasing its significance alongside classic shuttles in balancing cellular functions. Explore its implications in neurological conditions like Parkinson's and autism, questioning previous assumptions on its minimal presence and emphasizing its importance in maintaining metabolic health.

Jul 12, 2024 • 2min
Handling Creatine Side Effects
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and fast or slow heartbeat. The full podcast and article can be found here: https://chrismasterjohnphd.substack.com/p/handling-creatine-side-effects

Jul 12, 2024 • 29min
Your Cells Are Starving For Creatine
Discover the importance of creatine in cellular functions and health benefits, from energy production to athletic performance and brain function. Explore the role of creatine in optimizing cell performance and the potential advantages of maintaining high creatine levels in the body.

Dec 18, 2023 • 23min
Is Whole Food Vitamin C Really Different? | Masterjohn Q&A Files #330
The podcast discusses the effectiveness and copper utilization of natural and synthetic vitamin C. It explores the roles of vitamin C in plants, including iron regulation and photosynthesis. The impact of vitamin C on copper levels and cerebral plasmin is also explored. Debunking myths about synthetic versus whole food vitamin C, the podcast provides insights on daily dosage.

Dec 4, 2023 • 30min
What's the Deal With Seed Oils? | Masterjohn Q&A Files #329
Exploring the oxidative liability of seed oils due to vulnerable polyunsaturated fatty acids. The role of vitamin E in protecting against lipid peroxidation. Need for moderation in consumption of seed oils to prevent potential harm.

Nov 20, 2023 • 24min
Is Hair Mineral Testing Useful? | Masterjohn Q&A Files #328
The podcast discusses the usefulness of hair trace mineral analysis for nutritional testing. It explores the limitations of hair mineral content as a test for specific minerals and highlights the need for corroboration from other validated tests. The chapters cover topics such as the value of HTMA for ultra trace minerals and edge cases, reliable markers for zinc deficiency, and recent scientific papers on hair mineral analysis.

13 snips
Nov 17, 2023 • 51min
Secrets to Superior Cognitive Performance (Without Drugs)
Explore the power of nutrition versus drugs for cognitive performance. Learn about the historical use of cocaine and coca leaves, the complexities of methylation, the significance of B12 and Collen, the role of glycine and other nutrients, genetic impairments, and ways to optimize cognitive performance without drugs.

Nov 16, 2023 • 7min
Vitamin C, Whole Food Vs. Synthetic: Does It Matter?
Debunking the myth of special tyrosinase complex in plant vitamin C, examining differences between whole food and synthetic vitamin C, exploring distinctions between vitamin K and C in plants, discussing absorption rates, highlighting benefits of flavonoids and vitamin C, importance of vitamin C and its concentrations in plants, effects on tyrosinase enzyme and cerebral plasmid, benefits of whole food vitamin C over synthetic ascorbic acid.

Nov 14, 2023 • 6min
Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation
A critique of Gary Brekka's lack of scientific background and limitations of his DNA test. Refutation of the claim that everything entering our bodies needs to be methylated. Discussion on specific targets and functions of methylation. Explanation of the conversion of T4 to T3 in the body, including iodine atom removal and replacement.
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