Popular guests

Obituaries editor at The Economist, remembering Oleg Gordievsky.

Pioneering cardiologist, longevity researcher, and one of the top 10 most cited medical researchers alive today. Founder and director of the Scripps Research Translational Institute.

Expert on technology, censorship, and geopolitical issues. Provides insightful analysis on the arrest of Pavel Durov and the implications for free speech.

Illustrator, animator, podcaster, YouTuber, and author of "Your Head is a Houseboat." Shares insights on journaling and mental clarity.

Partner at a16z, part of the consumer team. She analyzes consumer behavior shifts and the defensibility of AI-driven companies.

Political commentator, author, and media personality. Co-host of Breaking Points, one of the top political podcasts in America. Co-host of The Realignment podcast with Marshall Kosloff.

a16z Infrastructure partner who discusses AI-enabled developer tooling, agent orchestration, and the emerging AI software development stack; contributes technical and market insights on AI coding.

Creator of Nervous System Mastery, a course teaching evidence-backed protocols to cultivate calm, build resilience, and increase aliveness.

Expert in hormone optimization and GLP-1 agonists, sharing insights on clinical applications and emerging therapies.

CEO of Microsoft AI and co-founder of DeepMind. Expert in AI personality design and human-AI interaction.

Partner at Sequoia Capital, focusing on early-stage investments across various industries, including consumer marketplaces, fintech, robotics, and healthcare. He discusses Sequoia's commitment to partnering with daring founders from the earliest stages.

Celebrated Irish poet, philosopher, and speaker with multiple poetry volumes and bestselling prose collections; known for essays exploring language, seasonality, vulnerability, and the inner life.

Hacker and inventor, also the author of Deep Future: Creating Technology that Matters. Mananging partner at Deep Future and host of the Deep Future Podcast.

Entrepreneur, investor, and author of several books on business and ideas, including four on how to apply the 80-20 principle in all walks of life. His investments have grown at an average of 22% compounded annually over 37 years.

PhD candidate at the University of Cambridge and a US Air Force Veteran. Known for his insights on evolutionary psychology, cultural trends, and social dynamics.

YC partner and startup investor who frequently hosts Lightcone sessions discussing product, startups, and AI adoption in enterprise contexts.

Hospitality maverick and founder of Modern Elder Academy. Helped transform Airbnb from a startup to a global phenomenon and is an expert in midlife transitions.

Runs Internet Pipes and explores emerging trends. Previously worked at A16Z and The Hustle, focusing on data-driven insights and trend analysis.

Stripe cofounder. Host of the Cheeky Pint podcast where he interviews founders, builders, and leaders.

Writer, photographer, and walker based in Japan. Author of "Things Become Other Things" and "Kissa by Kissa", known for his extensive walks and writing.

Comedian and podcast host of What Now? with Trevor Noah, guiding the interview and discussion; also referenced in the episode as Microsoft’s “Chief Questions Officer.”

Professor of Political Science at the University of Chicago. Known for his work on international relations theory and critique of the Israel lobby.

Author of philosophy and entrepreneurship known for his surprising insights and succinct writing style. Formerly a musician, programmer, and TED speaker.

Author of The 5 Resets and internal medicine physician at Harvard. Provides quick and easy ways to minimize stress in daily life.

Covers national security and legal policy for The New York Times.

Founder of SaaStr and venture capitalist. Previously founded Storm Ventures.

Adjunct professor at Columbia Business School and host of the Value Investing with Legends podcast who guides conversations about value investing and company analysis.

Expert in helping entrepreneurs write and publish world-class books, known for his work with prominent authors like Tim Ferriss and Ramit Sethi.

Director of AI Everywhere and Gen AI for Intel Design, with expertise in AI product incubation, growth, and organizational transformation.

Defence editor at The Economist.

High-performance psychologist and host of the Finding Mastery podcast, interviewing world-class performers to translate mindset and mental skills into practical tools.

Co-founder of Anthropic, an AI safety and research company. Previously the policy director at OpenAI and a reporter at Bloomberg.

Legendary talent agent and Co-Founder of CAA (Creative Artists Agency). Expertise extends beyond people to creating institutional momentum.

Founder of ManTalks, a men's mental health company. He explores the loneliness epidemic in men, fatherless boys, and the decline in dating and relationships.

Leading researcher in reinforcement learning, 2024 Turing Award winner and author of 'The Bitter Lesson', known as a foundational figure in RL (TD learning, policy gradients).

White House reporter for The New York Times.

Treasury Secretary under President Trump, providing insights into economic policy and the impact of tariffs.

Principal Scientist and WHOOP Global Head of Human Performance, leading research on physiology, sleep, and recovery to inform WHOOP features and algorithms.

Research psychologist and author of "Grit." Co-host of the podcast "No Stupid Questions."

Indian entrepreneur and venture capitalist, offering insights into investment decisions and core human motivations.

Axios reporter known for his in-depth political reporting and interviews.

Co-founder of The Conscious Leadership Group and advisor to numerous leaders. Co-authored the book "The 15 Commitments of Conscious Leadership."

Historian and author of 'Moral Ambition: Stop Wasting Your Talent and Start Making a Difference', 'Utopia for Realists', and 'Humankind'. Known for his work on universal basic income and challenging conventional perspectives.

Founder of graphed.com and expert in AI automation. Discusses how to build productized services using AI tools.

Ark Media Contributor. Contributes to discussions on major developments between Israel and Hamas.

Engineering professor and author known for the popular Coursera course Learning How to Learn and for work on the science of learning; guest discussing free speech, course design, and learning strategies.

Creator of the Bullet Journal method and host of this podcast episode, guiding viewers through planning for the new year using bullet journaling.

Actor, bodybuilding legend, best-selling author, entrepreneur and former Governor of California. He is known for his roles in action movies like Terminator and Predator.

Life hacker who has saved millions by breaking down every aspect of life. Host of the All the Hacks podcast.

Writer, entrepreneur, and musician known for his minimalist approach to life and insightful observations on decision-making and achieving excellence.