Lifespan with Dr. David Sinclair

The Science of Keeping the Brain Healthy | Episode 7

Feb 16, 2022

01:01:48

Creator website

Episode guests

David Sinclair

AI Summary

Highlights

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

A Mediterranean diet can protect and reverse cognitive decline in the aging brain.

Exercise improves executive function and promotes the growth of new brain cells.

NAD boosters like NADH and NR can slow brain aging and improve cognitive function.

Deep dives

The Role of Diet, Exercise, and Supplements in Slowing Brain Aging

A Mediterranean diet has been shown to protect the brain from aging and may even reverse cognitive decline. Exercise, particularly aerobic and strength training, improves executive function and helps grow new brain cells. Metformin, an AMPK activator, has been found to improve cognitive function and prevent dementia in studies on fish, mice, and humans. NAD boosters, such as NADH and NR, can increase NAD levels in the brain and have been shown to slow brain aging and improve cognitive function. Supplements like resveratrol and terrestilbine also have potential benefits.

Importance of Omega-3 Fatty Acids for Brain Health

01:34

The Importance of Sleeping Well

01:02

Benefits of Mediterranean Diet on Brain Health

01:18

The Benefits of Fish Oil Supplements for Cognitive Function

01:11

Introduction

2min

All Timers Demento - A New Approach to Treating Dementia

5min

The New Idea of Aging

2min

How to Measure Aging in the Brain

2min

The Good and the Bad of Aging

2min

Are You Working on the Whole Body?

2min

The Plasticity of Technology

2min

Three Longevity Pathways That Respond to Adversity

3min

The Role of Certuins in Controlling Brain Aging

2min

10.

The Mediterranean Diet and Alzheimer's Disease

2min

11.

What Is It in a Mediterranean Diet That Can Help the Brain?

2min

12.

The Difference Between a Mediterranean Diet and a Western Diet

2min

13.

Is Homosistin a Predictor of Heart Disease?

2min

14.

Is Your Eyes a Window Into Your Brain?

2min

15.

The Importance of Getting Omega 3 Fatty Acids

2min

16.

Omega Three Fatty Acids Are Good for Your Brain

2min

17.

The Effects of Exercise on Alzheimer's Disease

2min

18.

Metforeman Is Good for Brain Health

2min

19.

How Do You Tell if a Fish Has Good Memory?

2min

20.

Metforman Is Not Good for Your Brain

2min

21.

Met Foreman Improves Cognitive Function in Diabetics

2min

22.

Is There a Better Way to Increase Ad Levels?

2min

23.

The Effects of N a D Plus on Brain Function

3min

24.

Increasing Blood Flow Is a Big Deal for Alzheimer's Disease

2min

25.

How to Prevent Alzheimer's Disease in a Mouse

2min

26.

How to Get Good Sleep at Night

2min

27.

Sleep Deprivation in Flies

1min

28.

Lash Is Superimportant That We Look After Our Brains

3min

29.

LifeSpan Podcast

2min

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclair
Levels - https://levels.link/sinclair
InsideTracker - https://insidetracker.com/sinclair

Our Patreon page: https://www.patreon.com/davidsinclair

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Matthew LaPlante's Social:

Twitter

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Introducing Episode Seven: Aging of the Brain

(00:04:39) Thanking the Sponsors

(00:07:38) Ex-differentiation as a Driver of Aging

(00:09:22) The Brain Ages Slowly

(00:14:17) Cognitive Function and Plasticity

(00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins

(00:23:26) Plant-based Diets and B-vitamins

(00:28:32) Homocysteine, Plaque, and Vasculature

(00:32:35) Fatty Acids

(00:35:48) Physical Activity

(00:39:14) Metformin

(00:46:02) NAD Boosters

(00:50:33) Increasing Blood Flor

(00:53:20) Sleep

(00:58:02) Overall Message: Keep your Brain Healthy

(00:58:50) Next Week’s Episode and the Future of Medicine

(01:01:21) Options for Subscription for Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Remember Everything You Learn from Podcasts

Save insights instantly, chat with episodes, and build lasting knowledge - all powered by AI.

Lifespan with Dr. David Sinclair

The Science of Keeping the Brain Healthy | Episode 7

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

The Role of Diet, Exercise, and Supplements in Slowing Brain Aging

The Impact of Sirtuins on Brain Aging

The Importance of NAD Supplementation for Brain Health

Benefits of Resveratrol and Olive Oil in the Mediterranean Diet

Nutritional Considerations for a Plant-Based Diet and Brain Health

Importance of Omega-3 Fatty Acids for Brain Health

The Importance of Sleeping Well

Benefits of Mediterranean Diet on Brain Health

The Benefits of Fish Oil Supplements for Cognitive Function

Remember Everything You Learn from Podcasts