Lifespan with Dr. David Sinclair
Lifespan Communications LLC
Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research.
A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life.
Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science.
Become a Lifespan member at lifespan.com.
New episodes every two weeks.
A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life.
Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science.
Become a Lifespan member at lifespan.com.
New episodes every two weeks.
Episodes
Mentioned books
Nov 1, 2026 • 52min
Prevent Alzheimer's with Peptides? | Lifespan with Dr. David Sinclair - S2, Ep. 12
Could peptides protect the brain from Alzheimer’s, repair tissue, boost muscle and gut health, or extend lifespan? This conversation explores humanin, MOTS-c, Klotho, BPC-157, growth hormone peptides, and the first FDA-approved mitochondrial medicine. It also separates credible human evidence from animal studies, hype, safety concerns, and the risks of experimenting in the peptide Wild West.
62 snips
Oct 18, 2026 • 56min
Younger Skin with Peptides? | Lifespan with Dr. David Sinclair - S2, Ep. 11
Peptides are reshaping conversations about skin, muscle, and longevity medicine. David Sinclair and Matthew LaPlante explore collagen peptides, GHK-Cu, Epitalon, and apelin, from cellular repair and stem cells to telomeres and exercise biology. They also examine gray-market sourcing, regulation, limited human evidence, and long-term safety, alongside a surprising change of heart on collagen.
132 snips
Oct 4, 2026 • 1h 1min
Could Ozempic Help You Live Longer? | Lifespan with Dr. David Sinclair - S2, Ep. 10
Could GLP-1 drugs become the first true longevity medicines? This conversation traces their journey from gut hormones and a Gila monster peptide to Ozempic, tirzepatide, and next-generation triple agonists. It explores mouse lifespan results, early human aging research, effects across aging hallmarks, microdosing, brain signaling, gene therapies, and the safety questions surrounding long-term use.
136 snips
Sep 19, 2026 • 49min
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9
Could a sweet-tasting amino acid help support a longer, healthier life? David Sinclair and Matthew LaPlante explore glycine’s roles in collagen, antioxidant defenses, blood sugar, heart health, memory, and recovery. They examine its connection to methionine restriction, autophagy, and the survival circuit, along with findings from animal studies and early human research.
129 snips
Sep 11, 2026 • 31min
How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8
Explore how food influences aging through chronic inflammation, glycation, blood sugar, and the gut microbiome. The conversation covers fermented foods, fiber, plant compounds, nutrient sensing, insulin sensitivity, fasting, and exercise, along with practical approaches to supporting beneficial gut bacteria and longevity pathways.
127 snips
Sep 4, 2026 • 31min
Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7
Why does aging begin before we can see it? This conversation explores the hallmarks of aging, from failing mitochondria and chronic inflammation to exhausted stem cells and disrupted communication between organs. It also examines exercise, cold exposure, longevity compounds, mitochondrial replacement, and the potential and limits of future stem cell therapies.
221 snips
Aug 21, 2026 • 1h 11min
Why Exercise Slows Aging | Lifespan with Dr. David Sinclair
They trace human endurance back to persistence hunting and explain why modern sedentary life clashes with our biology. The conversation covers how movement triggers cellular repair pathways, affects metabolism, immunity, brain health, and cellular aging. Practical topics include how much activity is optimal, why sitting breaks matter, the importance of strength and VO2 max, and why social sports may add extra benefits.
252 snips
Aug 7, 2026 • 1h 9min
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5
Clear, practical advice on exercising for a longer life, not peak athleticism. Discussion of which fitness metrics matter most like VO2 max and grip strength. Guidance on balancing cardio, strength, and balance training across the week. Tips on timing, caffeine, protein, fasting, wearables, and how exercise should change with age.
176 snips
Jul 23, 2026 • 1h 12min
Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
A deep dive into eye aging, from retinal anatomy to why the eye reveals biological age. They discuss epigenetic reprogramming and the first human age-reversal trial restoring vision in primates. Conversation covers macular degeneration mechanisms, links between eyes and brain, and practical factors like sleep, diet, supplements, light exposure, and pressure that affect long-term vision.
296 snips
Jul 12, 2026 • 1h 8min
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3
A practical guide to timing meals and syncing eating with body clocks to boost metabolic health. Hour-by-hour breakdowns explain what happens at 12, 24, and 48+ hours of fasting. Deep dive into cellular recycling, ketones for brain fuel, and molecular pathways like sirtuins and AMPK. Tips on safe implementation, meal windows, sex-specific considerations, tracking biomarkers, and troubleshooting plateaus.
