Critical Care Reviews Podcast

TAME Trial Presentation

Jul 24, 2023

01:22:29

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Episode notes

Introduction

3min

The Impact of Cardiac Arrest on Brain Function

3min

The Effects of Mild Hypercapnea on Brain Function and Neurological Outcomes

4min

The TTM2 Trial: Six Inclusion Criteria

4min

The Results of the TTM 2 Trial

3min

The Effects of Cardiac Arrest on Arterial Carbon Dioxide Levels

4min

The Primary and Secondary Outcomes of the Taintra

3min

The Effects of Mild Hypercapnia on Neurological Outcomes

3min

The Effects of Hypercapnia on Brain Function

3min

10.

What Went Wrong With the TAM Trial?

3min

11.

The Randomization of a Postcardic Rest Trial

2min

12.

The Distribution of Mean Values in the Two Groups

4min

13.

The Importance of Physiology in Clinical Trials

3min

14.

The Effects of Hypercapnea on Outcomes

3min

15.

The Effect of Random Fluctuation on Hypercapnea

2min

16.

The Disadvantages of a Neutral Trial

3min

17.

The Challenges of Hypercopnia Interventions in Intensive Care

3min

18.

The Titanic and the Horse Bolt

2min

19.

The GOSI and the Neutrality of the Results

6min

20.

The Interaction Between CO2 and Temperature in Hospital Arrest Patients

5min

21.

The Effects of PACO2 on Oxygen Levels in Emergency Rooms

3min

22.

The Future of TBI Monitoring

3min

23.

The Effects of Arterial Carbon Dioxide on Cardiovascular Function

5min

24.

The Importance of Neutral Trials

4min

25.

The Effect of CO2 on Ventilation in TBI

3min

Glenn Eastwood presents the results of the TAME cardiac arrest trial, investigating mild hypercapnoea post cardiac arrest. He is joined by senior investigators Alistair Nichol (Dublin) and Stephen Bernard (Melbourne). An independent editorial is delivered by Lars Andersen (Aarhus). Darren Taichman (Philadelphia) chairs a panel discussion consisting of Flavia Machado (Sao paulo), Joyce Yeung (Birmingham, UK) and Andrew Althouse (Pittsburgh), as well as the other speakers.