The Distribution of Mean Values in the Two Groups

The outcome was measured and assessed using valid methodologies. I also think this is a low risk of bias. The manuscript, which is very well written, follows the protocol. And then we're left with the intervention itself and whether or not the hypothesis was correct. So the intervention, as Glenn mentioned, was a normal capnia, a mild hypercapnia for 24 hours. That led to a pilot trial that then led to the actual tamer salts study.