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Perimenopause is characterized by hormonal fluctuations, particularly a decline in progesterone, starting as early as the mid-30s. This phase can lead to symptoms such as weight gain, anxiety, hot flashes, and emotional swings, often exacerbated by lifestyle factors. It's crucial to monitor hormone levels through testing to identify any significant changes in estrogen and progesterone throughout this transitional period. Baseline measurements taken earlier in life can provide valuable insight, though recent assessments can still be beneficial.