The Human Upgrade with Dave Asprey

The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254

250 snips
Feb 25, 2025
Chris Rhodes, a biochemist and longevity researcher, discusses groundbreaking fasting mimetics that could transform health without the need to fast. He explains how Mimeo, a blend of four fasting metabolites, can extend lifespan by 96% while maintaining food intake. The conversation covers optimal fasting windows, the dangers of over-fasting on metabolism and hormones, and why traditional longevity drugs may not be effective. Rhodes highlights the balance between indulgence and health, paving the way for innovative approaches to nutrition.
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ADVICE

Optimal Fasting Window

  • Aim for an 18-hour intermittent fasting window.
  • Longer fasts can create biological stress, resembling starvation.
INSIGHT

The Magic of 36-Hour Fasts

  • A 36-hour fast provides optimal lifespan and healthspan extension.
  • Over-fasting can negatively impact socialization and potentially lead to adverse effects.
INSIGHT

Fasting Metabolites

  • Over 300 metabolites are significantly upregulated during a 36-hour fast.
  • Mimeo replicates fasting's benefits using four key metabolites: nicotinamide, spermidine, PEA, and OEA.
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