AI Snips
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Differentiate SBI From IBI
- SBI includes UTI, bacteremia, and meningitis while IBI includes only bacteremia and meningitis.
- Focusing on IBI isolates the infections that carry the highest risk and avoids UTI-driven distortion of risk estimates.
Procalcitonin Outperforms WBC And CRP
- Procalcitonin and CRP outperform white blood cell count for identifying serious infections in young infants.
- Procalcitonin has the best AUC, especially for invasive bacterial infection, and should be used when available.
Use PCT-Based Prediction Rules
- Use Procalcitonin-based clinical prediction rules (Step-by-Step or PCARN) when you have access to PCT.
- These rules markedly reduce missed IBIs and can safely reduce invasive testing and admissions.