Patrick Holford: Simple Wisdom for a Healthy Life The Ageless Brain - How do you ensure you never get cognitive decline, Alzheimer's and dementia?
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May 2, 2025 
In this insightful discussion, Dr. Dale Bredesen, a renowned neurologist and author of 'The End of Alzheimer's', shares groundbreaking strategies for combating cognitive decline. He explores the innovative Ketoflex 12.3 dietary framework, emphasizing metabolic flexibility and plant-rich nutrition. Bredesen challenges the myth of inevitable memory loss with aging, advocating for proactive cognitive testing and stress management techniques like HeartMath. He delves into the impact of viral infections and the significance of the APOE4 gene, highlighting lifestyle changes that empower brain health.
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Phases of Alzheimer's Progression
- Alzheimer's progresses through four phases: asymptomatic, subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and dementia.
- Early intervention can reverse or halt progression in the first three phases, with some improvements even in dementia phase.
Start Alzheimer's Prevention Early
- Cognitive decline starts subtly and almost linearly lowers cognitive test scores from age 18 onward.
- Alzheimer's prevention should start early and aims to extend brain health for the entire lifespan.
Mentors with Sharp Minds
- Dr. Linus Pauling was mentally sharp until shortly before his death despite cancer.
- Dr. Abram Hoffer maintained brain function and lived peacefully into his 90s without chronic disease.
