FoundMyFitness

In this engaging discussion, Kevin Rose, a tech entrepreneur and health enthusiast, dives into cutting-edge research on brain health and nutrition. He examines how phospholipid DHA boosts cognitive function and the longevity effects of metformin. The benefits of sulforaphane from cruciferous vegetables and its impact on brain health are highlighted. They also explore magnesium threonate for cognitive enhancement and how sauna use can mimic the effects of exercise, improving overall wellness. Intriguing insights for health aficionados!

Dive into the fascinating world of resveratrol and its potential as a longevity compound. Discover how this plant-derived substance can improve cardiovascular biomarkers and offer anti-inflammatory benefits. Learn about the surprising effects on cognition and memory, as well as its role in extending healthspan in animals. The discussion reveals the complex interplay of resveratrol with exercise and its effects on drug metabolism. Find out what factors influence its bioavailability and the implications for supplementation.

Discover the crucial role of NAD+ in the aging process and how its levels decline over time. Learn about the promising precursors, nicotinamide riboside and nicotinamide mononucleotide, and their potential to boost NAD+. The discussion also tackles whether NAD+ boosters can promote cancer growth and explores why direct supplementation of NAD+ might not be effective. Tune in for insights from current research and clinical trials that could reshape our understanding of longevity and cellular health.

Dr. David Sinclair, a Harvard genetics professor and aging researcher, shares fascinating insights into the mechanisms of aging and how to potentially slow it down. He reveals how caloric restriction, fasting, and compounds like resveratrol can activate longevity genes. The discussion also covers the role of NAD+ in reversing aging processes and the exciting potential of reprogramming adult cells into stem cells. Listeners will learn about promising advancements in cognitive health, particularly in relation to Alzheimer's, and how NMN and NR might improve brain function.

Discover how sauna use might mimic the benefits of exercise for heart health and longevity. Clinical research reveals significant improvements in cardiovascular well-being through regular sauna bathing. The comparison between Finnish sauna and Waon infrared therapy unveils intriguing differences. Heat shock proteins play a crucial role in mediating the health benefits, while sauna use is shown to reduce inflammation. Plus, it's an enjoyable and safe practice anyone can consider integrating into their routine!

Discover the science behind exercise as a powerful antidote to depression. Learn how physical activity boosts serotonin, enhances neuroplasticity, and increases endorphins. Explore the intricate link between inflammation and mental health, revealing how exercise helps reduce harmful compounds. Delve into the dual role of IL-6 during workouts and its impact on mood. This insightful discussion unpacks various exercise types and their specific benefits, making a compelling case for incorporating movement into mental health management.

Dr. Elissa Epel, a leading professor at UCSF, dives into the fascinating world of telomeres and their critical role in aging. She discusses how stress, nutrition, and lifestyle factors, like exercise and meditation, can influence telomere length and overall health. Epel highlights the damaging effects of sugar and stress on our biological age, while emphasizing the importance of maintaining a healthy lifestyle to promote longevity. Discover the intricate connections between our choices, cellular health, and the quest for a better quality of life as we age.

Matthew Walker Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science.  Walker's research examines the impact of sleep on human health and disease. One area of interest focuses on identifying "vulnerability windows" during a person's life that make them more susceptible to amyloid-beta deposition from loss of slow wave sleep and, subsequently, Alzheimer's disease later in life. Dr. Walker earned his undergraduate degree in neuroscience from the University of Nottingham, UK, and his Ph.D. in neurophysiology from the Medical Research Council, London, UK. He is the author of the New York Times best-selling book Why We Sleep: Unlocking the Power of Sleep and Dreams. In this episode, we discuss: (00:00) Introduction (08:47) Sleep boosts learning (21:21) Manipulating sleep to enhance learning (26:28) REM sleep, dreams, and memory encoding (34:46) Sleep deprivation causes loneliness (46:36) Sleep is disturbed in all neuropsychiatric conditions (52:30) Bright light exposure  (01:00:02) How much sleep is enough? (01:10:21) Inflammation triggers sleep (01:26:16) Bidirectional relationship between poor sleep and Alzheimer's disease (01:35:12) Deep sleep deprivation increases beta-amyloid (01:41:40) Preventing dementia (01:48:44) Sleep tracking technology (01:56:25) Four Pillars of Sleep (02:06:02) Metabolism and microbiome (02:23:34) Tips for better sleep If you’re interested in learning more, you can read the full show notes here. Join over 300,000 people and get the latest distilled information on sleep for enhanced learning straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This episode features a Q&A session with Dr. Rhonda Patrick. The questions were sourced from social media followers of both FoundMyFitness and also Zero Fasting Tracker, a convenient mobile app used widely in the fasting community for logging. In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including: (00:00) Introduction (03:46) What effects do coffee, supplements, and amino acids have on fasting? (12:29) Should you consume electrolytes on a fast? (14:50) What evidence is there that one method of fasting is more beneficial than others? (24:01) What effect does the consumption of exogenous ketones have on fasting? (29:30) Are there downsides to exercise during fasting? (34:31) What role does fasting play in the growth-longevity tradeoff? (49:48) What's the ideal way to break a fast? If you’re interested in learning more, you can read the full show notes here. Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dale E. Bredesen Dale E. Bredesen, M.D., is a professor of neurology at the Easton Laboratories for Neurodegenerative Disease Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr. Bredesen's laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer's disease and other neurodegenerative conditions. He has collaborated on the publication of more than 220 academic research papers. In this episode, we discuss: (00:00) Introduction (06:00) What is Alzheimer's disease? (09:29) Alzheimer's types - hot, dry, and toxic (18:56) APOE-4 gene triples risk of Alzheimer's disease (20:55) Cognoscopy for dementia detection (23:11) Lifestyle interventions (32:33) Keto flex 12/3 diet can treat dementia (50:58) Omega-3s resolve inflammation (57:39) Sauna use detoxifies the body  (01:06:05) Available consumer tests If you’re interested in learning more, you can read the full show notes. Join over 300,000 people and get the latest distilled information on alzheimer's disease straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor