FoundMyFitness #049 Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More
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Nov 6, 2019 
Dr. David Sinclair, a Harvard genetics professor and aging researcher, shares fascinating insights into the mechanisms of aging and how to potentially slow it down. He reveals how caloric restriction, fasting, and compounds like resveratrol can activate longevity genes. The discussion also covers the role of NAD+ in reversing aging processes and the exciting potential of reprogramming adult cells into stem cells. Listeners will learn about promising advancements in cognitive health, particularly in relation to Alzheimer's, and how NMN and NR might improve brain function.
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Longevity Genes
- Aging is controlled by longevity genes, not anti-aging genes.
- These genes, found in various organisms, activate during exercise and fasting to repair the body.
NAD and Sirtuins
- Calorie restriction, fasting, and exercise increase NAD levels, activating sirtuins.
- NAD is crucial for mitochondrial function and DNA repair, and its levels decline with age.
NAD Fluctuation
- NAD levels fluctuate based on circadian rhythms, food intake, and exercise, impacting sirtuin activity.
- Jet lag may be linked to disrupted NAD cycles.
