The Real Science of Sport Podcast

The Science of Fatigue

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Apr 6, 2023
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ANECDOTE

Three-Day Gravel Ride Fatigue

  • Ross and Mike experienced varied fatigue over three days of gravel riding, with improvement by the third day.
  • This real-life example highlights how fatigue can fluctuate and adapt during repeated endurance efforts.
INSIGHT

Fatigue as Brain-Regulated Decline

  • Fatigue is not absolute failure but a progressive decline regulated by the brain to preserve homeostasis.
  • It's a context-specific, complex interaction of muscle and brain signals adjusting effort to avoid danger.
INSIGHT

Muscle Energy and Fatigue Chemistry

  • Muscle contraction requires ATP produced primarily through carbohydrate and fat metabolism aided by oxygen.
  • Lactate is not a cause of fatigue but a useful fuel, while other metabolites impede muscle function.
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