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The Rich Roll Podcast
The Ant-Viral Gut: Robynne Chutkan, MD On Optimizing Immunity & Preventing Disease From The Inside Out
Oct 31, 2022
02:19:29
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Quick takeaways
- Proton pump inhibitors and NSAIDs can disrupt gut bacteria balance and increase the risk of infections.
- Hormonal therapy can affect gut bacteria balance and should be personalized based on individual risk factors.
- Understanding the impact of medications on the gut microbiome is crucial for overall health.
- Maintaining healthy mucus production is essential for protecting the body from pathogens.
- Fever plays a role in fighting viral infections and tightening gut junctions, reducing intestinal permeability.
Deep dives
PPIs and their impact on the gut microbiome
Proton pump inhibitors (PPIs), commonly used to treat acid reflux, can disrupt the balance of gut bacteria and increase the risk of infections. Long-term use of PPIs can lead to intestinal permeability (leaky gut) and increase the risk of complications.
The impact of NSAIDs on gut health
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and Advil, can cause erosions in the gut lining and increase intestinal permeability. These changes can lead to dysbiosis and make individuals more susceptible to infections.
The role of hormonal therapy on gut bacteria
Hormonal therapy, such as birth control pills, can affect the balance of gut bacteria and contribute to dysbiosis. Although these medications serve important purposes, it's essential to consider their potential impact on gut health and personalize their use based on individual risk factors.
The comprehensive nature of medication impact
Understanding the potential ramifications of medications on the gut microbiome is crucial for overall health. It's important to approach medication use holistically and consider how it may disrupt the balance of gut bacteria, increase intestinal permeability, and impact the immune system.
The Benefits of Mucus and its Role in the Body
Mucus serves a crucial role in protecting the body's organs and systems. Not only does it provide a protective layer for the intestinal lining and prevent the stomach from being damaged by acid, but it also acts as a sticky matrix that traps harmful substances and pathogens. The mucus, along with the cilia in the lungs, helps to remove these trapped substances by either coughing them out or swallowing them. Suppressing mucus production, as done by cough suppressants and antihistamines, can hinder the body's defense mechanisms. Maintaining healthy mucus production through hydration and avoiding irritants is essential for overall health.
The Therapeutic Power of Fever
Fever is a natural defense mechanism of the body and plays a crucial role in fighting viral infections. It helps to slow down viral replication and enhance the immune response. Fever also tightens the junctions between cells in the gut, reducing intestinal permeability and preventing viruses from penetrating the gut lining. While it is common to reach for antipyretics to reduce fever, it is important to understand the therapeutic benefits of fever and allow the body time to fight off the infection naturally. Research is even exploring the potential of thermal therapy as a treatment for respiratory diseases and cancer.
The Importance of Fiber and Short-Chain Fatty Acids for Gut Health
Increasing fiber intake in the diet and focusing on specific types of fiber, such as inulin, can have a profound impact on gut health. Certain fibers are preferred food sources for beneficial gut bacteria, promoting the production of short-chain fatty acids like butyrate. These fatty acids not only regulate the immune system but also act on viral receptors and help tighten the gut junctions, reducing intestinal permeability. It is crucial to prioritize a diet rich in a variety of plant-based foods to support the growth of a healthy gut microbiome.
The Link Between Sleep, Gut Health, and Immune Function
Sleep plays a vital role in maintaining a healthy gut and immune system. It has a profound impact on serotonin production in the gut, which influences the production of melatonin, the sleep hormone. Adequate sleep leads to optimal immune function, while sleep deprivation can weaken the immune response and increase the risk of viral infections. Getting quality sleep, avoiding unnecessary antibiotic use, and ensuring exposure to nature can all contribute to better gut health and overall well-being.
The Importance of Avoiding Harmful Practices
The podcast emphasizes that it is more important to focus on stopping or decreasing practices that harm healthy microbes, rather than solely adding probiotics. The speaker mentions that not washing as much can be beneficial for skin conditions like rosacea and hair loss, as it allows the skin and scalp microbes to regenerate. The podcast highlights the shift towards pro-bacterial products and the innovation in the market, but emphasizes the significance of working in harmony with our body's natural processes.
Understanding Long COVID and Gut Health
The podcast explores the concept of long COVID and the impact of gut health on this condition. While post-viral syndromes are not new, the speaker notes that the post-viral landscape of long COVID is still being understood. Research shows microbial differences and autoimmune markers in patients with long COVID. The podcast emphasizes the need for more long-term studies and the potential role of fecal microbiota transplants (FMT). However, the speaker highlights that FMT alone is not a simplistic solution and that dietary changes and the quality of transplanted stool are key considerations for its effectiveness.
42.
COVID - What Are the Most Important Things That We Should Be Paying Attention To?
2min
Multiple studies now confirm a dramatic link between the health of our microbiome and our ability to combat viral illness. Today we explore this connection, with tools to promote gut health, optimize your immune system & prevent disease.
Our host for today's exploration is the queen of all things gut health, Robynne Chutkan, MD.
Dr. Chutkan is a board-certified gastroenterologist serving on the Georgetown University Hospital faculty. She is the founder of the Digestive Center for Wellness, as well as the author of 4 books on the microbiome, including her most recent, The Anti-Viral Gut, which offers practical advice for optimizing diet, exercise, sleep, and time outdoors to boost the body’s defenses and our overall health.
Appearing for the 2nd time on the podcast, my initial conversation with Dr. Chutkan 7 years ago (RRP #192) dove into the nuts and bolts of the microbiome: what it is, how it functions, and how we can care for it. Today we zoom in, focusing on the antiviral aspects of gut health, why it’s so important, and what you can do about it.
We’ve talked a lot about the microbiome on this podcast, but this exchange is truly a masterclass within itself.
Watch: YouTube.
Read: Show notes.
I’ve known Robynne for many years—she is such a delightful presence. It was wonderful to have her back in the studio. Her expertise in communicating this subject matter is truly unparalleled, and I am excited to share this one with you. Enjoy!
Peace + Plants,
Rich
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