Harley Finkelstein, President of Shopify and a serial entrepreneur who started his first business at 13, shares his insights on the transformative nature of entrepreneurship. He discusses how anxiety can fuel success and why now is an ideal time for aspiring business owners. The conversation dives into the importance of democratizing entrepreneurship, the impact of immigrants on the startup ecosystem, and the vital role of storytelling and mental health in leadership. Finkelstein emphasizes that purpose-driven ventures define true success.

Josh Szeps, a renowned broadcaster and host of Uncomfortable Conversations, dives into the importance of authentic dialogue in today's polarized society. He highlights the challenges of misinformation and media partisanship, emphasizing the need for grace in discourse. Szeps explores the impact of COVID-19 measures on personal liberties in Australia and the U.S., and critiques the Democratic Party's struggles with identity politics. This engaging discussion advocates for empathy and understanding as vital tools to bridge societal divides.

Dr. Charan Ranganath, a leading neuroscientist and UC Davis professor, dives deep into the captivating world of memory. He reveals how memories are more like impressionistic paintings than snapshots, constantly reshaped by our emotions and contexts. The conversation covers the impact of memory on identity and healing, the malleability and unreliability of recollections, and how modern distractions like smartphones dilute our memory formation. Ranganath also explores techniques for improving memory retention and how emotions play a crucial role in encoding and retrieval.

David Roche, an iconoclastic ultrarunner, broke the Leadville 100 record on his very first try. He discusses his unconventional methods, emphasizing scientific precision and the importance of mental resilience. Roche shares how embracing vulnerability in both running and life led him to unexpected achievements. He also delves into innovative training techniques, including the use of bicarbonate, and the significance of Zone Two training for endurance athletes. His journey illustrates a new era in human performance that encourages athletes to push boundaries and redefine possibilities.

Kristian Blummenfelt, an Olympic champion and sub-7-hour Ironman record holder, dives into the mental struggles and resilience needed after setbacks in high-stakes races like Kona. He shares insights on the emotional toll of failures and why losing can hurt more than winning feels rewarding. Blummenfelt also discusses the importance of adaptable training strategies and reflections on his transition from Olympic racing to Ironman, revealing how science-driven methods elevate performance in endurance sports.

Dr. Robin Berzin, Founder and CEO of Parsley Health, is revolutionizing primary care with her focus on functional medicine and root-cause treatment. She discusses her innovative 'Brains, Bones and Booty' protocol tailored for women's longevity. Berzin delves into the importance of personalized health insights and technology in improving overall well-being. She highlights the need for systemic change in healthcare, particularly in addressing multi-chronic conditions and women's unique health challenges. Tune in for a glimpse into the future of holistic health!

Esther Perel, a renowned psychotherapist and bestselling author, dives deep into the complexities of modern relationships. She discusses the delicate balance between security and freedom in love, and how societal changes impact intimacy and desire. Esther explores the significance of vulnerability, the need for honest communication about sexuality, and the role of self-awareness in relationships. She also reflects on the influence of technology and AI on human connections, emphasizing the importance of evolving narratives and ongoing effort to maintain intimacy.

Cory Richards, a renowned National Geographic photographer known for his iconic avalanche selfie, dives deep into his life grappling with bipolar disorder and trauma. He shares personal stories of triumph and struggle, emphasizing the importance of true self-acceptance over external validation. The conversation unveils the complexity of mental health and success, detailing how climbing adventures serve as a metaphor for resilience. Highlights include the healing power of vulnerability, community support, and confronting one's inner chaos while navigating the world.

Rebecca Rusch, a legendary endurance athlete and 7-time world champion, shares her transformative journey after a traumatic brain injury from a biking accident. She discusses the challenges of navigating healthcare and the often invisible nature of brain injuries. The conversation dives into the power of acceptance, the role of psychedelic-assisted therapy, and the importance of community support in recovery. Rusch emphasizes the emotional dimensions of healing and encourages a shift from performance-driven expectations to embracing inner growth.

Bruce Dickinson, the legendary frontman of Iron Maiden, showcases his multifaceted life as an airline pilot and Olympic-caliber fencer. Joined by filmmaker Sacha Gervasi, they delve into Bruce's captivating journey from a bullied schoolboy to a rock icon. He shares his experiences flying into war zones, surviving cancer, and why he could moonlight as an MI6 agent. Their conversation also touches on the emotional and creative resilience shaped by extraordinary life events, revealing the unique intersection of music, aviation, and personal transformation.