In 'Smarter Not Harder,' Dave Asprey exposes the surprising secrets of the body's operating system, or 'MeatOS,' which is naturally designed to be lazy. He shows how to hack this system to achieve optimum wellness by exercising and eating smarter, not harder, and utilizing the body's built-in laziness. The book is packed with practical information on better eating, smart workouts, and strategic therapies to reduce stress and boost resilience, aiming to upgrade metabolic, neurological, and epigenetic systems.
The Bulletproof Diet is a comprehensive guide to achieving better mental clarity, sustained energy, and weight loss through a high-fat, moderate-protein, and low-carbohydrate approach. The diet emphasizes eating organic, grass-fed, and non-GMO foods to minimize toxins and maximize nutrient intake. It also incorporates intermittent fasting and the consumption of healthy fats like avocados, coconut oil, and grass-fed butter. The diet aims to stabilize blood sugar levels, promote weight loss, and support cognitive function. Key components include the use of Bulletproof Coffee, avoiding mold toxins, and a balanced approach to exercise and sleep[1][3][5].
Everything you’ve been told about weight loss is a lie!
In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health.
Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional dieting often fails—and what actually works. From the role of ketosis in healing chronic illness to the surprising ways fasting affects hair loss, metabolism, and inflammation, this episode is packed with actionable insights that you won’t hear anywhere else.
You’ll also learn how viruses might be fueling food addiction, why gut health is the missing key to metabolic recovery, and how new research could unlock the future of personalized medicine. If you’ve ever felt like your metabolism was holding you back, this conversation will give you the tools to take control of your health for good.
What You’ll Learn:
• Why calorie counting is useless—and the better way to lose weight
• The shocking truth about how your metabolism ACTUALLY works
• How ketosis and fasting can heal inflammation and chronic disease
• The role of gut health and microbiome diversity in weight loss
• New research on food addiction and its surprising link to viruses
• Why individualization is the key to sustainable health
Resources:
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Nick Norwitz’s YouTube – https://www.youtube.com/@nicknorwitzPhD
• Nick Norwitz’s Website – https://www.nicknorwitz.com/
• Follow Nick on Instagram – https://www.instagram.com/nicknorwitz/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
SPONSORS:
Timestamps:
• 00:00 Trailer
• 00:39 Meet Dr. Nick
• 04:44 Nick’s Health Journey
• 07:54 Keto Diets
• 09:37 Modern Medicine Challenges
• 13:31 Exercise vs. Diet
• 14:32 Obesity Memory
• 17:36 Keto Cycling
• 20:51 Microbiome Health
• 26:26 Fasting & Hair Loss
• 34:56 Alzheimer’s Insights
• 45:11 Cold Plunge Benefits
• 45:43 Dopamine Boosts
• 46:26 Cold Plunge & Inflammation
• 47:15 Best Time to Cold Plunge
• 48:18 Pain & Dopamine
• 49:31 Exercise & Stress
• 51:49 Cholesterol & Inflammation
• 01:05:42 Debunking Calories In/Out
• 01:07:09 Food Addiction
• 01:11:15 Metabolic Health Tips
• 01:24:13 Nick’s Mission
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Human Upgrade with Dave Asprey 
