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Why Intravascular Volume Falls In Sepsis
- Sepsis reduces effective intravascular volume mainly through vasodilation increasing venous capacitance.
- Inflammation and capillary leak further shift fluid into the interstitial space and can cause hypovolemia on presentation.
Factors That Shift Fluid Extravasation
- Fluid distribution depends on infusion speed, blood pressure, and anesthesia status.
- Faster infusions and certain physiologic states increase fluid leakage to the interstitial space.
Avoid Excessive Fluid To Prevent Organ Edema
- Avoid excessive fluid administration because accumulated interstitial fluid causes organ edema and dysfunction.
- Monitor for rising intra-abdominal pressure and pulmonary, cardiac, or renal edema as signs of harm from fluid overload.