The Jesse Chappus Show 617: Longevity Scientist Reveals How to Slow Aging & Even Reverse It! | Dr. David Sinclair
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Sep 10, 2024 
Dr. David Sinclair, a leading world authority on aging and a Professor at Harvard, dives into the science of longevity and aging. He discusses innovative gene therapies that may reverse aging effects and shares insights into dietary impacts on health. Sinclair elaborates on breakthroughs in rejuvenation for pets and the similarities with human health. He emphasizes the significance of a plant-based diet and fasting, all while exploring the connection between stress management, sleep quality, and overall well-being.
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Information Theory of Aging
- Aging is caused by corrupted biological software, not just wear and tear.
- This "software", the epigenome, controls gene expression and can be corrupted over time.
Genome vs. Epigenome
- Cells have two types of information: the genome (DNA) and the epigenome.
- The epigenome controls which genes are read and when, and its corruption is a key driver of aging.
Skin Cell Cloning
- David Sinclair uses a skin cell cloning example to illustrate that DNA doesn't age.
- It's the epigenome that loses its ability to read the DNA correctly, leading to age-related decline.