The Jesse Chappus Show

Dr. Sarah Myhill is a British physician and author specializing in chronic fatigue and ME. She explores how thyroid function, mitochondria, gut fermentation, toxins, and nutrition shape energy. They discuss iodine, heavy-metal detoxification, paleo-ketogenic eating, food allergies, supplements, glucose monitoring, and isometric exercise for rebuilding energy.

Dr. Robert Cywes, a dual board-certified surgeon and metabolic health specialist, explores carbohydrate addiction, emotional eating, and insulin resistance. He discusses how excess sugar affects the liver, why boundaries and planned meals matter, and healthier ways to regulate emotions. The conversation covers animal-based nutrition, fasting, GLP-1 medication, movement, and the long road toward metabolic recovery.

Dr. Dominic D’Agostino, a University of South Florida researcher specializing in ketosis and metabolic therapies, explores the science and practice of sardine fasting. They discuss ketosis, appetite control, autophagy markers, cognitive performance, electrolytes, exogenous ketones, MCT oil, fish choices, and potential nutritional gaps. He also shares practical guidance for planning and tracking a three-day fast.

Dr. Matthew Phillips is a neurologist and researcher exploring metabolic and mitochondrial therapies for brain disease. He discusses the links between metabolic dysfunction, Alzheimer’s, Parkinson’s, ALS, and glioblastoma. Topics include fasting, ketosis, sleep, deep rest, mitochondrial health, cancer metabolism, and combining lifestyle strategies with conventional treatment.

Robb Wolf, former research biochemist, bestselling author, and LMNT co-founder, explores ancestral health beyond diet dogma. He discusses his recovery from severe illness, metabolic dysfunction, GLP medications, fasting, sunlight, sleep, electrolytes, and practical low-carb nutrition. He also shares training strategies for staying strong after 50 and explains why community may be a key pillar of healthy aging.

Dr. Anthony Jay, biochemist, author, and health consultant, explores what may drive arterial plaque beyond LDL alone. They discuss insulin resistance, fat-burning metabolism, seed oils, oxidation, microplastics, plant sterols, and the role of vitamin K2. The conversation also covers CAC scans, cardiometabolic testing, fasting, exercise, and emerging approaches to plaque reversal.

Bella Ma, Juilliard-trained musician turned Steak and Butter Gal, chronicles her switch from years of veganism to a multi-year carnivore experiment. She describes the first bite that sparked clarity, ravenous phases of eating lots of meat, and reintroducing raw dairy and high-fat protocols. Conversations cover ketosis testing, organ and raw beef trials, hormone recovery, and practical tips for dining and adaptation.

Nicole Laurent, a licensed mental health counselor and metabolic psychiatry practitioner who focuses on ketogenic metabolic therapy. She discusses how food shapes brain energy and why ultra-processed foods act like drugs. She explains when and how ketogenic approaches can help, practical steps to reduce carbs and raise ketones, and key nutrients and monitoring needed for brain recovery.

Dr. David Perlmutter, a board-certified neurologist and bestselling author on brain health. He explores microglia and how metabolic dysfunction drives brain disease. The gut microbiome, ultra-processed foods, and lifestyle choices shape risk. Practical starts include diet, sleep, movement, targeted supplements, and emerging therapies like hyperbaric oxygen and GLP-1 drugs.

Dr. Michael Breus, double board-certified clinical psychologist and sleep specialist, shares practical sleep protocols and why you wake at night. He explains chronotypes, a step-by-step middle-of-night routine, effects of alcohol and meds on sleep architecture, and simple hacks like the three 15s, temperature timing, naps, and tech for better rest.