Freely Filtered, a NephJC Podcast

Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin or Not so toxic

Oct 17, 2022

01:09:45

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Highlights

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Episode notes

Cystatancy and Acute Kidney Injury

01:32

Chronic Kidney Disease - What's Next?

01:33

Is There a Time Frame for Nephrotoxicity?

01:50

Introduction

3min

The Biomedical Community on Twitter

2min

Nephrology Podcast - Freely Filter

2min

Is Pip Taz Vanko Really Nephrotoxic?

2min

Is There a Pseudo-Naphrotoxicity?

2min

Is There a Synergistic Nephrotaxis?

2min

Is AKI Causing Toxicity or Is It the AKI?

2min

Is There a Risk of Creatinine Defined AKI?

2min

Sistadency and the Sepsis Cohort

2min

10.

The Mesh Study of Sepsis in the ICU

4min

11.

How Did You Determine AKI With Cystad in C?

2min

12.

Cystatency in AKI

2min

13.

Is Cystatency a Biomarker of Kidney Function?

2min

14.

The Key Aspect Is Selection Bias

2min

15.

Confounding by Indication - What's the Right Approach?

2min

16.

What Are the Big Confoundings in This?

2min

17.

AKI - What's Your Go-to Antibiotic?

2min

18.

The Epidemiology of Sepsis

3min

19.

Piptazo Versus Cephaline - What's the Key Finding?

2min

20.

The Ratio of Systatin C to Creatinine in the Pitasal Arm

1min

21.

AKI in the Piptaso Group Versus Sephapine Group

2min

22.

Is Piptaso a Better Drug or Sephapine?

2min

23.

Is There a Null Association Between Piptaso and Mortality?

2min

24.

Cystatancy and Acute Kidney Injury

2min

25.

Is Cystatancy Going to Be One of the New Labs?

3min

26.

Do We Need to Use Van Copyptha?

2min

27.

Is This Nephrotoxic or Pseudo-Dephrotoxicity?

2min

28.

Is There a Time Frame for Nephrotoxicity?

2min

29.

Is Creatinine a Good Biomarker?

2min

30.

Chronic Kidney Disease - What's Next?

2min

31.

Is This Going to Be the Next Venus Contrast to Be?

2min

32.

RCTs Are the Pinnacle of Our Pledge Drive

2min

33.

The Best Place to Go to Play Golf Is Bandon Dunes

3min

The Filtrate:

Joel Topf

Swapnil Hiremath

Nayan Arora

Priya Yenebere

Special Guests:

Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine.

Show Notes:

Early Pip/Tazo article showing nephrotoxicity. Covered by NephJC

Linazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study and Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis.

Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine

Vancomycin-Associated Cast Nephropathy: Reality or Fantasy?

Molecular Epidemiology of SepsiS in the ICU (MESSI) prospective cohort. Learn about it her: A multibiomarker-based outcome risk stratification model for adult septic shock*

Cystatin C in acute kidney injury

Changing Definitions of Sepsis

Proposed new definitions of AKI incorporating biomarkers: Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference. A Consensus Statement in JAMA Network Open

Applications of propensity score methods in observational comparative effectiveness and safety research: where have we come and where should we go?

The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study

Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals

PulmCrit – Myth-busting the conditional nephrotoxicity of piperacillin-tazobactam by Josh Farkas

Sharp Objects on Good Reads

Bandon Dunes

The Ocean Course at Kiawah Island Golf Resort

Be Real follow me: BeRe.al/kidney_boy

SNL spoof of BeReal

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